The influence of sweet pepper pectin structural characteristics on cytokine secretion by THP-1 macrophages

Nascimento, Georgia Erdmann do; Winnischofer, Sheila Maria Brochado; Ramirez, Marcel I.; Iacomini, Marcello; Cordeiro, Lucimara M.C.

doi:10.1016/j.foodres.2017.09.037

Cited by 39 publications

(25 citation statements)

References 39 publications

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“…14 Similar in vitro immunostimulatory properties of sweet pepper pectin were also preserved in modified fractions obtained by acid hydrolysis where side chains had been removed showing lower M W and DM. 27 In addition, lavender pectic polysaccharides containing a low-acetylated and high-methoxylated HG domain and RG-I fragments rich in arabinan and arabinogalactan showed anti-inflammatory activity on murine macrophages, 28 and smaller pectic oligosaccharide chains may also regulate anti-inflammatory cytokine secretion (IL-1 receptor antagonist and IL-10) and may also inhibit the activity of IL-1β. 29 Selenylation of low methyl-esterified pectin from Ulmus pumila L., containing galactan and glucan in its side chains, inhibited nitric oxide production in RAW 264.7 cells resulting in a potential anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

et al. 2019

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“…Many dietary fibers, including pectins, can directly interact with innate immune cells, such as macrophages or DCs, and influence their responses [70][71][72][73] . It has been suggested that dietary fibers are transported into the PP through M cells and activate immune cells, and this effect has been demonstrated for pectins 70,[74][75][76] .…”

Section: Pectin and Innate Immune Responses After Uptake In Peyer's Pmentioning

confidence: 99%

“…It has been suggested that dietary fibers are transported into the PP through M cells and activate immune cells, and this effect has been demonstrated for pectins 70,[74][75][76] . In addition, in vitro studies have demonstrated that pectins activate or inhibit the responses of DCs and macrophages through direct interaction with immune receptors [71][72][73]77 . The activation and inhibition of macrophage and DC responses may be beneficial to the host under different circumstances.…”

Section: Pectin and Innate Immune Responses After Uptake In Peyer's Pmentioning

confidence: 99%

The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells

2020

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Pectins are dietary fibers with different structural characteristics. Specific pectin structures can influence the gastrointestinal immune barrier by directly interacting with immune cells or by impacting the intestinal microbiota. The impact of pectin strongly depends on the specific structural characteristics of pectin; for example, the degree of methyl-esterification, acetylation and rhamnogalacturonan I or rhamnogalacturonan II neutral side chains. Here, we review the interactions of specific pectin structures with the gastrointestinal immune barrier. The effects of pectin include strengthening the mucus layer, enhancing epithelial integrity, and activating or inhibiting dendritic cell and macrophage responses. The direct interaction of pectins with the gastrointestinal immune barrier may be governed through pattern recognition receptors, such as Toll-like receptors 2 and 4 or Galectin-3. In addition, specific pectins can stimulate the diversity and abundance of beneficial microbial communities. Furthermore, the gastrointestinal immune barrier may be enhanced by short-chain fatty acids. Moreover, pectins can enhance the intestinal immune barrier by favoring the adhesion of commensal bacteria and inhibiting the adhesion of pathogens to epithelial cells. Current data illustrate that pectin may be a powerful dietary fiber to manage and prevent several inflammatory conditions, but additional human studies with pectin molecules with well-defined structures are urgently needed.

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“…Pectin can regulate biological activities via the interaction with immune cells. Pectin treatment increases TNF-α, IL-1β, and IL-10 cytokines (Figure 5 ) ( 87 ). Further work showed that the degree of methyl esterification, molecular size, and the characteristics of pectin structure were closely associated with the regulation of cytokine.…”

Section: Pos Affect Mitogen-activated Protein Kinases (Mapk) Signalinmentioning

confidence: 99%

Pectin Oligosaccharides Ameliorate Colon Cancer by Regulating Oxidative Stress- and Inflammation-Activated Signaling Pathways

et al. 2018

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Colon cancer (CC) is the third common neoplasm worldwide, and it is still a big challenge for exploring new effective medicine for treating CC. Natural product promoting human health has become a hot topic and attracted many researchers recently. Pectin, a complex polysaccharide in plant cell wall, mainly consists of four major types of polysaccharides: homogalacturonan, xylogalacturonan, rhamnogalacturonan I and II, all of which can be degraded into various pectin oligosaccharides (POS) and may provide abundant resource for exploring potential anticancer drugs. POS have been regarded as a novel class of potential functional food with multiple health-promoting properties. POS have antibacterial activities against some aggressive and recurrent bacterial infection and exert beneficial immunomodulation for controlling CC risk. However, the molecular functional role of POS in the prevention of CC risk and progression remains doubtful. The review focuses on antioxidant and anti-inflammatory roles of POS for promoting human health by regulating some potential oxidative and inflammation-activated pathways, such as ATP-activated protein kinase (AMPK), nuclear factor erythroid-2-related factor-2 (Nrf2), and nuclear factor-κB (NF-κB) pathways. The activation of these signaling pathways increases the antioxidant and antiinflammatory activities, which will result in the apoptosis of CC cells or in the prevention of CC risk and progression. Thus, POS may inhibit CC development by affecting antioxidant and antiinflammatory signaling pathways AMPK, Nrf2, and NF-κB. However, POS also can activate signal transduction and transcriptional activator 1 and 3 signaling pathway, which will reduce antioxidant and anti-inflammatory properties and promote CC progression. Specific structural and structurally modified POS may be associated with their functions and should be deeply explored in the future. The present review paper lacks the important information for the linkage between the specific structure of POS and its function. To further explore the effects of prebiotic potential of POS and their derivatives on human immunomodulation in the prevention of CC, the specific POS with a certain degree of polymerization or purified polymers are highly demanded to be performed in clinical practice.

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The influence of sweet pepper pectin structural characteristics on cytokine secretion by THP-1 macrophages

Cited by 39 publications

References 39 publications

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells

Pectin Oligosaccharides Ameliorate Colon Cancer by Regulating Oxidative Stress- and Inflammation-Activated Signaling Pathways

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