The influence of surface treatment on hydrophobicity, protein adsorption and microbial colonisation of silicone hydrogel contact lenses

Santos, Lívia; Rodrigues, Diana Alexandra Ferreira; Lira, Madalena; Oliveira, M. Elisabete; Oliveira, Rosário; Vilar, Eva Yebra-Pimentel; Azeredo, Joana

doi:10.1016/j.clae.2006.12.007

Cited by 78 publications

(41 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many influence factors from adsorbents should take into account, for example, chemical composition [190], dissolution behaviour or pH [79,[191][192][193], degree of crystallization [194], microstructure, hydrophobicity [195][196][197][198], z-potential [199], surface roughness [200][201][202] surface reactivity [203], etc. Obviously, different types of adsorbent substrates would greatly affect the protein-adsorption results.…”

Section: Influence Factors From the Substrates And Mediamentioning

confidence: 99%

A review of protein adsorption on bioceramics

et al. 2012

View full text Add to dashboard Cite

Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic -protein interactions.

show abstract

Section: Influence Factors From the Substrates And Mediamentioning

confidence: 99%

A review of protein adsorption on bioceramics

et al. 2012

View full text Add to dashboard Cite

show abstract

“…One commercially available preservative free multidose eyedropper (Novelia ® , marketed by Nemera ® ) contains silicone parts isolating the solution from the outside, by using silicone's properties of gas permeation to allow pressure equilibrium with drop release and properties of shape memory to act as a valve. Silicone is a material known for being at risk of interactions with certain drugs it comes in contact with, be it wanted or not, for example proteins, ciprofloxacin and prostaglandins (4)(5)(6). Such a device is therefore especially at risk of developing interactions with the ophthalmic drugs it could be put into contact with.…”

Section: Introductionmentioning

confidence: 99%

A Sorption Study between Ophthalmic Drugs and Multi Dose Eyedroppers in Simulated Use Conditions

Basle

Chennell

Sautou

2017

Pharmaceutical Technology in Hospital Pharmacy

View full text Add to dashboard Cite

AbstractPreservative free ophthalmic formulations need to be packaged either as single doses, or using specially designed sterility preserving multidose eyedroppers. Our objective was to evaluate potential sorption phenomena between a device with a silicone sterility preserving membrane and the delivered drops of several ophthalmic solutions. Cyclosporine, rifamycin, latanoprost, timolol and norfloxacin were used as model drugs. Quantification of the active substance in delivered drops (1 to 4 drops per day) from low density polyethylene (LDPE) bottles without any sterility preserving device and from LDPE bottles with a sterility preserving silicone membrane (LDPE-Si) was performed for 14 days (n≥3), using validated HPLC methods. For cyclosporine, mean concentrations did not vary by more than 10 % from reference concentrations for either LDPE or LDPE-Si eyedroppers, but for LDPE-Si, the concentrations of the 1 mg.ml-1 cyclosporine micellar solution were found to be significantly lower than for those from LDPE eyedroppers (p=0.0127). For LDPE-Si, rifamycin mean concentrations decreased by 11.2 % throughout the 14 day study period, but didn’t vary by more than 10 % for LDPE and glass eyedroppers. However, rifamycin concentrations from LDPE-Si were not significantly different from those from LDPE eyedroppers. For latanoprost, whilst mean concentrations did not vary by more than 10 % from reference concentration for LDPE eyedroppers, for LDPE-Si eyedroppers concentrations decreased by 76.4 % at their lowest concentration and never returned to their initial level. For timolol and norfloxacin, mean concentrations did not vary by more than 10 % for either LDPE or LDPE-Si eyedroppers and no significant difference was found between the 2 eyedroppers concentrations. Our results are in favor of an absence of significant sorption between LDPE-Si eyedroppers for timolol or norfloxacin ophthalmic solutions. Further studies should be performed on cyclosporine ophthalmic micellar solutions and rifamycin ophthalmic solutions before any definite conclusions can be made. Finally, our results show that latanoprost ophthalmic solutions shouldn’t be used with LDPE-Si eyedroppers as the loss of active substance would cause a sever under-dosing.

show abstract

“…Protein films form a distinct group of surface deposits, characterized by a thin and semi opaque superficial layered appearance. Although silicone-hydrogel lenses usually adsorb a lower amount of proteins than the conventional hydrogel ones 9 , it is important to study the influence of protein deposits on some silicone-hydrogel contact lenses properties, such as UVVisible transmittance.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have evaluated the spectral transmittance for a variety of tinted and UVblocking soft lenses [2][3][4][5][6] . Protein deposition is one of the most frequent contaminants occurring on hydrophilic contact lenses, resulting from the interaction between the tear film and the polymer of a contact lens [7][8][9] and may modify the lens optical properties 7 . Protein films form a distinct group of surface deposits, characterized by a thin and semi opaque superficial layered appearance.…”

Section: Introductionmentioning

confidence: 99%

UV-visible transmittance of silicone-hydrogel contact lenses measured with a fiber optic spectrometer

et al. 2013

View full text Add to dashboard Cite

Protein deposition is one of the most frequent contaminants occurring on hydrophilic contact lenses and may modify the lens optical properties. The silicone-hydrogel contact lenses usually adsorb a lower amount of proteins than the conventional hydrogel ones. However it is important to study the influence of protein deposits on some silicone-hydrogel contact lenses properties, such as UV-Visible transmittance. In this study it is measured de UV-Visible properties of new and worn silicone-hydrogel contact lenses and the transmittance changes that can occur with wear are quantified.An optical fiber spectrometer has been used for measuring the transmittance of contact lenses. This spectrometer has the advantage that the lens can be positioned horizontally and the light beam passes through it perpendicularly. For the measurements, it was necessary to make a special cuvette to put inside the lens and keep it submerged in sterile saline solution.The contact lenses used were Biofinity ® . They are manufactured by CooperVision with a material whose technical name is Comfilcon A. This material has not yet been analyzed for this purpose. Moreover, in this type of studies are commonly taken lenses of power -3.00D, however we have not limited to a single power value but we have extended the range to lower and higher values regarding to the standard power in order to see how this parameter affects.

show abstract

The influence of surface treatment on hydrophobicity, protein adsorption and microbial colonisation of silicone hydrogel contact lenses

Cited by 78 publications

References 22 publications

A review of protein adsorption on bioceramics

A review of protein adsorption on bioceramics

A Sorption Study between Ophthalmic Drugs and Multi Dose Eyedroppers in Simulated Use Conditions

UV-visible transmittance of silicone-hydrogel contact lenses measured with a fiber optic spectrometer

Contact Info

Product

Resources

About