The Influence of Surface Bioactivated Modification on Titanium Percutaneous Implants Anchored in Bone

Abstract

In order to achieve biological sealing and resist mechanical damage of load-bearing percutaneous devices, Ti with excellent mechanical properties was anodic-oxidized to be endowed with bioactivity, with plasma-sprayed hydroxyapatite coated Ti as control. Similar to previous works, hydroxyapatite coating could bond tightly with living tissues, resulting in implant stability for whole implantation periods. Meanwhile, when anodic-oxidized bioactivated Ti was implanted percutaneously in vivo, it could induce a layer of calcium phosphate at the interface of tissues/implant. This layer of Ca-P not only induced the fibrous tissue or collagen ingrowth in its structure, but also improved the osteointegration between the bone and the implant. There was no significant biological response difference for the anodic-oxidized Ti and HA coated Ti at different implantation period with histological statistical analysis (p>0.05). Accordingly, suitable bioactivated modified surface of Ti by anodic-oxidized method could not only obtain the same results as the HA coating, but also might avoid some drawbacks of plasma-sprayed HA coatings to achieve biological sealing for a long period in vivo.

Regulation on the biocompatibility of bioactive titanium metals by type I collagen

“…4,5 It could also form biological sealing with skin in percutaneous application when it was subjected to anodic oxidation treatment. 6 Recently, it was even found that the titanium metal could induce bony tissue formation at nonosseous site when it was subjected to chemical surface modification. 7 However, most research revealed that the tissue response of the titanium metal was different when it was subjected to different surface modification.…”

“…[10][11][12] It has been found that the apatite layer forming at the interface is the preliminary condition for the bioactive bonding, osteoinduction and biological sealing responses of the titanium metals. 6,13 Therefore, the different interaction between the collagen and implant surface is crucially important. To design the surface modification method for different application purpose, it is essential to study the different collagen adsorption ability on titanium metal subjected to different modification.…”

Relating scratch resistance to injection molding‐induced morphology of polypropylene

“…When it was subjected to suitable surface modification, it could form bioactive bonding with bony tissue 4, 5. It could also form biological sealing with skin in percutaneous application when it was subjected to anodic oxidation treatment 6. Recently, it was even found that the titanium metal could induce bony tissue formation at nonosseous site when it was subjected to chemical surface modification 7.…”

“…Bone mineral crystals are found within the collagen fibrils; and the fibril structure and organization limit the size of the crystals and control their orientation 10–12. It has been found that the apatite layer forming at the interface is the preliminary condition for the bioactive bonding, osteoinduction and biological sealing responses of the titanium metals 6, 13. Therefore, the different interaction between the collagen and implant surface is crucially important.…”