The influence of substituted phenols on the sol:gel transition of hydroxypropyl methylcellulose (HPMC) aqueous solutions

Banks, Simon R.; Pygall, Samuel R.; Bajwa, Gurjit S.; Doughty, Stephen W.; Timmins, Peter; Melia, Colin D.

doi:10.1016/j.carbpol.2013.10.061

Cited by 15 publications

(7 citation statements)

References 22 publications

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“…Benecel™ HPMC E5 was donated by Ashland Inc. (Covington, KY, USA). HPMC has been investigated for the preparation of oral drug delivery systems and is one of the most widely used hydrophilic matrix materials (Banks et al, 2014; Colombo, 1993). It can significantly affect the release kinetics of APAP due to its high swellability (Siepmann and Peppas, 2012).…”

Section: Methodsmentioning

confidence: 99%

Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation

Zhang

Yang

et al. 2017

Carbohydrate Polymers

166

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The objective of this study was to develop a new approach for fabrication of zero order release of active pharmaceutical ingredients (APIs) using hot-melt extrusion (HME) and 3D printing technology to generate tablets with specific 3D structures. By correlating the geometry of the 3D printed tablets with their dissolution and drug release rates, mathematical models that have been developed to describe drug release mechanisms were also studied. Acetaminophen was used as a model drug, and Benecel™ hydroxypropyl methylcellulose (HPMC) E5 and Soluplus® were used to formulate nine fuse depositional 3D-printed tablets with different inner core fill densities and outside shell thicknesses. This work reports the successful fabrication of solid-dispersion filaments with an API dispersed in HPMC based matrix via HME technology, and the production of zero order controlled release tablets with different 3D structures (tablets #3, 5, 6, and 9) using a 3D printer.

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Section: Methodsmentioning

confidence: 99%

Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation

Zhang

Yang

et al. 2017

Carbohydrate Polymers

166

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“…Such chemical modifications improve the water solubility, thus overcome certain material limitations for the technical applications. Cellulose derivatives have been widely used as a coating material, emulsifier, thickener, binder, and filler for food and drug production (Banks et al, 2014;Ding et al, 2014); however, their usages in the area of additive manufacturing is still in its infancy.…”

Section: Introductionmentioning

confidence: 99%

Printability of a Cellulose Derivative for Extrusion-Based 3D Printing: The Application on a Biodegradable Support Material

et al. 2020

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Support material plays a leading role in the application of 3D printing to avoid deformation and enhance stability. This study aimed to fabricate the support structure by using hydroxypropyl methylcellulose (HPMC), which has advantages over conventional material such as low cost, low printable temperature, and high biodegradability. Once dissolved in water over gelling temperature, the HPMC based hydrogel exhibited shearthinning behavior with decreasing apparent viscosity values at higher shear rates. The shear-dependent viscosity makes the HPMC hydrogel extrudable throughout the printing process and the printed structure stable enough without deformation. As concentration increased, apparent viscosity, and storage modulus both subsequently increased. These rheological properties indicated that the concentration of HPMC K4M hydrogel significantly influenced the printability and shape retention ability, which is associated with the mechanical strength of printed filaments. The highest concentration, 12% w/v, should have the best ability to hold the printed shape over time due to the highest G' and lowest loss tangent. The printability test also showed that K4M 12% w/v could be printed into different fill density (100, 75, and 50%) with different patterns, i.e., rectilinear and Hilbert curve. The selection of fill density and pattern both have an effect on surface roughness and porosity. The printed support material was compatible with acrylonitrile butadiene styrene (ABS), which is the material to fabricate the main structure for 3D printing. The support material made of HPMC can be easily removed by peeling off from the main structure without visible residual.

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“…Preformulation studies showed that fenugreek leaf aqueous extract is incompatible with commonly used gelling agents such as carbopol and cellulose derivatives such as CMC, HPMC, or HPC. Studies have shown that phenolic compounds could affect the gelling of cellulose derivatives such as HPMC 47 and the phenolic compounds present in the fenugreek leaf extract could be responsible for the incompatibility. Such an incompatibility was not observed when sodium alginate was used as a gelling agent.…”

Section: Discussionmentioning

confidence: 99%

Fenugreek Leaf Extract and Its Gel Formulation Show Activity AgainstMalassezia furfur

Kulkarni

Hastak

Jadhav

et al. 2020

ASSAY and Drug Development Technologies

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Malassezia spp. are commensal yeasts that can cause cutaneous ailments such as dandruff and seborrheic dermatitis. We sought to develop a cost-effective, herbal formulation for the treatment of cutaneous ailments related to Malassezia spp. Aqueous and ethanolic extracts of fenugreek (Trigonellafoenum-graecum L.) leaves exhibited activity against a clinical isolate and commercial strain of Malassezia furfur. The extracts were also found to be active against other pathogenic fungi such as Aspergillus niger and Candida albicans. Qualitative and quantitative phytochemical evaluation of aqueous extract showed a predominant presence of flavonoids apart from alkaloids, saponins, carbohydrates, phenols, and proteins. Gel formulation of 30% aqueous fenugreek leaf extract was developed and optimized using sodium alginate as a gelling agent. The formulation showed good physicochemical characteristics and retained activity against M. furfur during 3-month accelerated stability studies. Furthermore, the developed herbal gel formulation did not show any irritation or sensitization in New Zealand rabbits after topical application, proving its cutaneous safety. Thus, topical gel formulation containing fenugreek leaf aqueous extract could be a safe and effective herbal treatment for various cutaneous fungal infections, including dandruff.

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The influence of substituted phenols on the sol:gel transition of hydroxypropyl methylcellulose (HPMC) aqueous solutions

Cited by 15 publications

References 22 publications

Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation

Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation

Printability of a Cellulose Derivative for Extrusion-Based 3D Printing: The Application on a Biodegradable Support Material

Fenugreek Leaf Extract and Its Gel Formulation Show Activity AgainstMalassezia furfur

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