Hydroxypropyl methylcellulose-based controlled release dosage by melt extrusion and 3D printing: Structure and drug release correlation

Abstract

The objective of this study was to develop a new approach for fabrication of zero order release of active pharmaceutical ingredients (APIs) using hot-melt extrusion (HME) and 3D printing technology to generate tablets with specific 3D structures. By correlating the geometry of the 3D printed tablets with their dissolution and drug release rates, mathematical models that have been developed to describe drug release mechanisms were also studied. Acetaminophen was used as a model drug, and Benecel™ hydroxypropyl methylcellulose (HPMC) E5 and Soluplus® were used to formulate nine fuse depositional 3D-printed tablets with different inner core fill densities and outside shell thicknesses. This work reports the successful fabrication of solid-dispersion filaments with an API dispersed in HPMC based matrix via HME technology, and the production of zero order controlled release tablets with different 3D structures (tablets #3, 5, 6, and 9) using a 3D printer.

Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing

“…This is attributed to the closed, compact structure of the wall. This observation was consistent with the results of a previous study [34]. The tablets with 100% infill densities demonstrated pulse release at the end of 4.5 ± 0.26 h, followed by 75% infill (2 ± 0.22 h), and 50% infill (0.5 ± 0.19) ( Figure 7C).…”

Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

“…Overall, the weight uniformity of all the printed tablets, paracetamol and aspirin, ranges from a lower range of 1324 mg (paracetamol) to an upper range of 1918 mg (aspirin) with significant differences between some tablets being shown as previously outlined with the exception of significant differences between 2.50% Para and 5.00% Para. These findings reported here of dimensional accuracy and weight uniformity as well as the observations reported in the literature [22,45,54,[83][84][85][86] illustrate that AM and in particular the SLA process has the potential to be exploited in the fabrication of dosage forms for a variety of medical conditions. This is evident in the ability to print dosage forms comprised of various monomer(s)/photoinitiator(s)/drug concentrations and/or combinations of each which show excellent consistency in their dimensions with reference to the STL file that was imported into the software of the printer.…”

‘Temporary Plasticiser’: A novel solution to fabricate 3D printed patient-centred cardiovascular ‘Polypill’ architectures

“…Fused deposition modelling (FDM) 3D printing has therefore been proposed as an alternative method for 3D printing of tablets [16,17] and medical devices [18]. The method allows the fabrication of immediate [19][20][21], delayed [22,23], extended release tablets [24][25][26][27][28] as well as for dual drug delivery systems [29][30][31]. The technology offers several advantages such as the lower cost, absence of finishing step, small place requirement and obviation for material recycling [13,32].…”