The influence of substance P on the response of guinea‐pig isolated ileum to periarterial nerve stimulation

Grbović, Leposava; Radmanoviě, B.Ž.

doi:10.1111/j.1476-5381.1983.tb09420.x

Cited by 17 publications

(1 citation statement)

References 9 publications

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“…Pharmacological evidence indicates that these sensory nerve endings are endowed with various receptors for transmitters and autacoids (e.g. opioids, y-aminobutyric acid (GABA), and prostaglandins), the activation of which produces changes in excitability, thereby regulating the amount of released transmitter (Szolcsanyi & Bartho, 1978;Yaksh et al, 1980;Grbovic & Radmanovic, 1983;Takaki et al, 1986;Bartho et al, 1987;Go & Yaksh, 1987;Saria et al, 1988a,b;Maggi et al, 1988a,b;Giuliani et al, 1989a,b). These modulatory influences can also be observed in peripheral tissues, indicating that the 'efferent' function of these primary sensory neurones can be regulated by other components of the autonomic nervous system.…”

Section: Introductionmentioning

confidence: 99%

Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

Takaki

Nakayama

1991

British J Pharmacology

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1 The effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated ileum was determined by use of capsaicin itself and electrical mesenteric nerve stimulation as stimuli. 2 NPY inhibited or suppressed the cholinergic contractile response produced by electrical mesenteric nerve stimulation while leaving the contractile response to a threshold concentration of capsaicin. 3 NPY had no effect on motor responses produced by a submaximal concentration of substance P, the putative endogenous mediator of the 'efferent' function of sensory fibres in this preparation. 4 It is concluded that NPY exerted a prejunctional inhibitory action on transmitter release from peripheral endings of capsaicin-sensitive nerves at interneuronal synapses.

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Section: Introductionmentioning

confidence: 99%

Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

Takaki

Nakayama

1991

British J Pharmacology

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Neuromuscular transmission in the gastrointestinal tract

Hoyle

Burnstock

1989

Comprehensive Physiology

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Actions of polypeptides at the neuromuscular junction

Wali

1985

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The effects of several polypeptides, e.g. angiotensin II, substance P, oxytocin and vasopressin, on the isolated frog gastrocnemius, chick biventer cervicis and rat hemodiaphragm preparations were studied using electrophysiological and neurochemical techniques. The effects of angiotensin II, substance P, oxytocin and vasopressin on neuromuscular transmission and muscle contraction were investigated by studying the following parameters: the directly and indirectly-elicited twitch and tetanic contractions, nerve compound action potential, uptake of 3H-methylcholine into nerve-muscle preparations, the contractures produced by depolarizing drugs, e.g. ACh or TEA. The results showed that angiotensin II (10(-10)-10(-6) M) and substance P (10(-7)-10(-6) M) enhanced neuromuscular transmission and muscle contraction by increasing the amplitudes of the indirectly-elicited twitch and tetanic contractions. Oxytocin and vasopressin (1-100 mU/ml-1) both depressed neuromuscular transmission by reducing the contractile and electrical response in the frog, chick and rat skeletal muscle. It was concluded that, like their effects on ganglionic transmission, the peptides can modify neuromuscular transmission. The mechanism by which these peptides produce their effects may be dependent on external calcium concentration. These peptides may affect both pre- and postjunctional mechanisms; prejunctionally by increasing/decreasing the release of ACh, and postjunctionally by affecting the sensitivity of the postjunctional membrane to depolarizing drugs and/or producing a contracture in the skeletal muscle.

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The influence of substance P on the response of guinea‐pig isolated ileum to periarterial nerve stimulation

Cited by 17 publications

References 9 publications

Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

Neuromuscular transmission in the gastrointestinal tract

Actions of polypeptides at the neuromuscular junction

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