The Influence of Stratum Corneum Morphology on Water Permeability

Potts, Russell O.; Francoeur, Michael L.

doi:10.1111/1523-1747.ep12470197

Cited by 309 publications

(189 citation statements)

References 33 publications

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“…The skin also serves as a diffusion barrier 1 , both to block penetration of undesired pathogens 2 , and to prevent excessive transepidermal water loss 3 . The outermost part of skin, the stratum corneum, and the immediate underlying tissue, the epidermis, consist of layered collections of avascular, keratinized cells, in an extracellular lipid matrix [4][5][6][7] . Structurally, unbound, 'free' water that easily diffuses through skin layers, and molecularly 'bound' water that is largely confined to its bonding sites 8 in the stratum corneum are essential to its barrier function.…”

Section: Introductionmentioning

confidence: 99%

Multimodal epidermal devices for hydration monitoring

et al. 2017

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Precise, quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skinbased pathologies, and regulating external appearance. Here we introduce multimodal sensors with important capabilities in this context, rendered in soft, ultrathin, 'skin-like' formats with numerous advantages over alternative technologies, including the ability to establish intimate, conformal contact without applied pressure, and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the skin. Systematic in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature, thermal conductivity, thermal diffusivity, volumetric heat capacity, and electrical impedance using simple analysis algorithms. Clinical studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.

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Section: Introductionmentioning

confidence: 99%

Multimodal epidermal devices for hydration monitoring

et al. 2017

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“…The implications of the biphasic structure of the stratum corneum on its transport properties have been explored previously. 30,33 For most compounds that are soluble in oil, the primary transport pathway seems to be the intercellular lipid matrix. 23 One way of increasing the permeation of drugs in the skin is by including permeation enhancers in the transdermal delivery formulation.…”

Section: Introductionmentioning

confidence: 99%

Multiscale Modeling Framework of Transdermal Drug Delivery

2009

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Abstract-This study addresses the modeling of transdermal diffusion of drugs to better understand the permeation of molecules through the skin, especially the stratum corneum, which forms the main permeation barrier to percutaneous permeation. In order to ensure reproducibility and predictability of drug permeation through the skin and into the body, a quantitative understanding of the permeation barrier properties of the stratum corneum (SC) is crucial. We propose a multiscale framework of modeling the multicomponent transdermal diffusion of molecules. The problem is divided into subproblems of increasing length scale: microscopic, mesoscopic, and macroscopic. First, the microscopic diffusion coefficient in the lipid bilayers of the SC is found through molecular dynamics (MD) simulations. Then, a homogenization procedure is performed over a model unit cell of the heterogeneous SC, resulting in effective diffusion parameters. These effective parameters are the macroscopic diffusion coefficients for the homogeneous medium that is ''equivalent'' to the heterogeneous SC, and thus can be used in finite element simulations of the macroscopic diffusion process. The resulting drug flux through the skin shows very reasonable agreement to experimental data.

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“…Table 2 demonstrates the open chemical formulas and physicochemical properties of NSAIDs, which have dermal and transdermal commercial preparations and of the molecules which are potential candidates in this group. The physiochemical properties of drugs are important in dermal and transdermal administration (Potts and Francoeur, 1991;Kalia et al, 1998;Prausnitz & Langer, 2008). The ideal candidate drugs have the following properties: water-solubility (> 1 mg/ml), lipophilicity (log P= 1-3), low molecular weight (< 500 Dalton) and low melting temperature (< 200°C) (Guy, 2007).…”

Section: Wwwintechopencommentioning

confidence: 99%