Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs

Okyar, Alper; Özsoy, Yıldız; Güngör, Sevgi

doi:10.5772/28461

Cited by 14 publications

(12 citation statements)

References 86 publications

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“…Oleh karena itu, komposisi minyak dalam formula sangat menentukan ukuran globul mikroemulsi. Namun, ukuran globul emulsi masih belum masuk ke dalam rentang optimum, yaitu sebesar 20-200 nm (Okyar, et al 2012). Ukuran globul yang mendekati nilai optimum adalah formula A1.…”

Section: Pengukuran Globulunclassified

Optimasi Formula Mikroemulsi Berbahan Dasar Crude Palm Oil (CPO) Sebagai Antioksidan Potensial Pada Kulit

Syafitri¹,

Adliani²,

Khoirunnisa³

et al. 2020

JIHP

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Crude Palm Oil (CPO) is one of the typical Indonesian plant that has potential effect as an antioxidant preparation. The purpose of this study was to produce microemulsion with CPO content that had good physical characteristics and also showed antioxidant activity. This research was divided into 3 stages i.e. microemulsion formulation, physical characterization and stability, and antioxidant activity evaluation. The microemulsion was formulated using Phase Titration Method with CPO as oil phase, surfactant tween 80, cosurfactant PEG 400 and aquadest. The treatment in this study was the addition of CPO with various concentration of 5%, 7.5%, and 10% (w/w). The optimum formula was A1 which contained 5% (w/w) CPO. The results showed that this formula had a globule size of 288.87 ± 20.94 nm, zeta potential of -0.36 mV, density of 1.024 ± 6.15x10-5 g/mL, and pH in the range of 4.5-6.5. The microemulsion was stable in storage for 28 days at 25ºC, stable against extreme temperature changes and agitation. The CPO-based microemulsion had IC50 value of 10.5 μg/mL which showed strong antioxidant activity. It can be concluded that CPO-based microemulsion had good physical stability and antioxidant activity for further cosmetic preparation.

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Section: Pengukuran Globulunclassified

Optimasi Formula Mikroemulsi Berbahan Dasar Crude Palm Oil (CPO) Sebagai Antioksidan Potensial Pada Kulit

Syafitri¹,

Adliani²,

Khoirunnisa³

et al. 2020

JIHP

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“…Similarly, IBU is one of the best tolerated NSAID, despite its low water solubility and poor gastrointestinal absorption. Due to the aforementioned solubility reasons and systemic side effects, the transdermal administration of NSAIDs has been studied using various formulation approaches [ 7 ]. At present, Voltarol ® is the only NSAID patch available in the UK.…”

Section: Introductionmentioning

confidence: 99%

Effect of Drug Loading Method and Drug Physicochemical Properties on the Material and Drug Release Properties of Poly (Ethylene Oxide) Hydrogels for Transdermal Delivery

Wong

Dodou

2017

Polymers

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Novel poly (ethylene oxide) (PEO) hydrogel films were synthesized via UV cross-linking with pentaerythritol tetra-acrylate (PETRA) as cross-linking agent. The purpose of this work was to develop a novel hydrogel film suitable for passive transdermal drug delivery via skin application. Hydrogels were loaded with model drugs (lidocaine hydrochloride (LID), diclofenac sodium (DIC) and ibuprofen (IBU)) via post-loading and in situ loading methods. The effect of loading method and drug physicochemical properties on the material and drug release properties of medicated film samples were characterized using scanning electron microscopy (SEM), swelling studies, differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FT-IR), tensile testing, rheometry, and drug release studies. In situ loaded films showed better drug entrapment within the hydrogel network and also better polymer crystallinity. High drug release was observed from all studied formulations. In situ loaded LID had a plasticizing effect on PEO hydrogel, and films showed excellent mechanical properties and prolonged drug release. The drug release mechanism for the majority of medicated PEO hydrogel formulations was determined as both drug diffusion and polymer chain relaxation, which is highly desirable for controlled release formulations.

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“…Non-steroidal anti-inflammatory drugs (NSAIDs) are extensively prescribed analgesics for the management of acute pain and inflammation leaded by chronic musculo-skeletal diseases such as rheumatoid arthritis, osteoarthritis, tendinitis, bursitis [1,2]. However, orally administration of these drugs triggers to unfavourable effects specifically on the stomach as the results of inhibition of prostaglandins protecting gastric mucosa and acidic characters of the drugs [2]. In addition, most of NSAIDs have cardiovascular side effects and renal toxicity [3].…”

Section: Introductionmentioning

confidence: 99%

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

Saribey¹,

Kahraman²,

Erdal³

et al. 2021

jrp

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The aim of this work was to develop colloidal nanocarriers for skin delivery of etodolac (ETD), which is a non-steroidal anti-inflammatory drug orally used for the management of acute pain and inflammation, but leads to unfavourable effects on the stomach. The oleic acid and blend of Labrasol/Trancutol P were used as oil phase and surfactant/co-surfactant mixture in the microemulsion formulations, respectively. ETD loaded microemulsions selecting the microemulsion region of pseudo-ternary phase diagrams were prepared, and then the microemulsions were characterised to confirm formation of oil in water microemulsions via optical isotropy, refractive index, droplet size, electrical conductivity, rheological behaviour and morphological analysis. In vitro permeation of ETD through porcine skin was evaluated using Franz diffusion cells for stable ETD loaded microemulsions. ATR-FTIR spectroscopy analysis was performed to elucidate interaction between the microemulsion components and stratum corneum structure on the molecular level. Confocal laser scanning microscopy analysis was further carried out to visualize skin penetration enhancement effect of the microemulsion formulation consisting of a model lipophilic fluorescent marker, Nile Red. The results indicated that the developed microemulsion formulation consisting of oleic acid, Labrasol, Transcutol P and water offer a potential approach to enhance skin delivery of ETD for topical treatment of inflammatory diseases.

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Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs

Cited by 14 publications

References 86 publications

Optimasi Formula Mikroemulsi Berbahan Dasar Crude Palm Oil (CPO) Sebagai Antioksidan Potensial Pada Kulit

Optimasi Formula Mikroemulsi Berbahan Dasar Crude Palm Oil (CPO) Sebagai Antioksidan Potensial Pada Kulit

Effect of Drug Loading Method and Drug Physicochemical Properties on the Material and Drug Release Properties of Poly (Ethylene Oxide) Hydrogels for Transdermal Delivery

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

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