The Influence of Statin Use on Breast Density

Boudreau, Denise M.; Rutter, Carolyn M.; Buist, Diana S.M.

doi:10.1158/1055-9965.epi-05-0802

Cited by 6 publications

(5 citation statements)

References 21 publications

(19 reference statements)

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“…These trials are likely to be useful in disentangling the complex relation between statins and cancer. Clinical trials of the effects of statins on breast cancer risk and biological end points, such as breast density, have been suggested but are not supported by our study findings (31,32,35,36).…”

Section: Discussioncontrasting

confidence: 93%

Statin Use and Breast Cancer Risk in a Large Population-Based Setting

Boudreau

Miglioretti

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Mechanistic studies suggest that 3-hydroxy-3-methylglutaryl CoA inhibitors (statins) reduce the risk of breast cancer. Observational studies offer mixed results. Methods: To evaluate the relation between statin use and breast cancer risk, we conducted a cohort study among women ages 45 to 89 years within an integrated health care delivery system. Information on statin use and covariates were obtained from automated databases. We identified breast cancer cases through the Surveillance, Epidemiology, and End Results registry. We used Cox proportional hazards models to estimate the hazard ratios (HR) and 95% confidence intervals (95% CI) for invasive breast cancer among statin users compared with nonusers. Results: Among 92,788 women studied from 1990 to 2004, median follow-up time was 6.4 years, and 2,707 breast cancer cases were identified. During the study period, 7.4%

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Section: Discussioncontrasting

confidence: 93%

Statin Use and Breast Cancer Risk in a Large Population-Based Setting

Boudreau

Miglioretti

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Some retrospective studies of patients receiving statins as lipidlowering drugs for the prevention of cardiac events showed a slight reduction in the incidence of breast cancer (15) and colorectal cancer (16). However, some other clinical studies (17)(18)(19) and two recent meta-analyses (20,21) found no evidence that the use of statins reduces the risk of cancer. A recent phase II trial also failed to reveal any relevant activity of phenylacetate against malignant glioma (22).…”

Section: Introductionmentioning

confidence: 99%

Cholesterol Starvation Induces Differentiation of Human Leukemia HL-60 Cells

et al. 2007

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Cholesterol metabolism is particularly active in malignant, proliferative cells, whereas cholesterol starvation has been shown to inhibit cell proliferation. Inhibition of enzymes involved in cholesterol biosynthesis at steps before the formation of 7-dehydrocholesterol has been shown to selectively affect cell cycle progression from G 2 phase in human promyelocytic HL-60 cells. In the present work, we explored whether cholesterol starvation by culture in cholesterol-free medium and treatment with different distal cholesterol biosynthesis inhibitors induces differentiation of HL-60 cells. Treatment with SKF 104976, an inhibitor of lanosterol 14-A demethylase, or with zaragozic acid, which inhibits squalene synthase, caused morphologic changes alongside respiratory burst activity and expression of cluster of differentiation antigen 11c (CD11c) but not cluster of differentiation antigen 14. These effects were comparable to those produced by all-trans retinoic acid, which induces HL-60 cells to differentiate following a granulocyte lineage. In contrast, they differed from those produced by vitamin D 3 , which promotes monocyte differentiation. The specificity of the response was confirmed by addition of cholesterol to the culture medium. Treatment with PD 98059, an inhibitor of extracellular signal-regulated kinase, abolished both the activation of NADPH oxidase and the expression of the CD11c marker. In sharp contrast, BM 15766, which inhibits sterol # 7 -reductase, failed to induce differentiation or arrest cell proliferation. These results show that changes in the sterol composition may trigger a differentiation response and highlight the potential of cholesterol pathway inhibition as a possible tool for use in cancer therapy. [Cancer Res 2007;67(7):3379-86]

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“…Caglayan et al [16] found no relationship between lipid parameters and breast density in a study of 215 postmenopausal women, of whom 40 were classified as having dense tissue and 175 were categorized as having non-dense breast tissue. An association between mammographic density and some anthropometric and biochemical parameters, such as age, body mass index, cholesterol levels, and transaminases, was reported by Jihyekim et al [17] Boudreau et al [18] found a correlation between statin usage and high mammographic breast density in their study, and Wei et al [19] reported that women who had a breast cancer diagnosis had a higher LDL-cholesterol and triglyceride level and a lower HDL-cholesterol level than the healthy control group in their study.…”

Section: Discussionmentioning

confidence: 80%

Hyperlipidemia and Mammographic Breast Density in Post-menopausal Women

Öztürk¹

2018

South Clin Ist Euras

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Breast cancer is the most common cancer type in women. High mammographic breast density is associated with an increased risk of breast cancer in women. The goal of this study was to investigate a possible association between mammographic breast density and hyperlipidemia. Methods: This retrospective study was conducted using the records of patients from between January and December of 2016 who met the inclusion criteria: postmenopausal women between the ages of 50 and 65 years who did not have diabetes mellitus and who had a contemporaneous digital mammography performed and had the appropriate laboratory data. A total of 164 women were included. Results: The mean age of the patients was 55.88±4.49 years. According to the Breast Imaging Reporting and Data System, 116 of the 164 patients (70.7%) were in the low-density group, and 28 patients (20.3%) were categorized as having a high-density result. The group with a high mammographic breast density had a significantly greater high-density lipoprotein (HDL) cholesterol level than the group with a low breast density (55.35±12.98 vs 51.14±12.38 mg/dL, respectively; p=0.035). The low-density lipoprotein cholesterol level of the high-density tissue group was greater than that of the low-density group, but was not statistically significant (146.5±37.22 vs 133.73±33.97 mg/dL, respectively; p=0.052). Conclusion: It was determined that a high HDL cholesterol level and older age were associated with breast density. There is a need for prospective, large-scale studies in this area.

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The Influence of Statin Use on Breast Density

Cited by 6 publications

References 21 publications

Statin Use and Breast Cancer Risk in a Large Population-Based Setting

Statin Use and Breast Cancer Risk in a Large Population-Based Setting

Cholesterol Starvation Induces Differentiation of Human Leukemia HL-60 Cells

Hyperlipidemia and Mammographic Breast Density in Post-menopausal Women

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