Hyperlipidemia and Mammographic Breast Density in Post-menopausal Women

Abstract

Breast cancer is the most common cancer type in women. High mammographic breast density is associated with an increased risk of breast cancer in women. The goal of this study was to investigate a possible association between mammographic breast density and hyperlipidemia. Methods: This retrospective study was conducted using the records of patients from between January and December of 2016 who met the inclusion criteria: postmenopausal women between the ages of 50 and 65 years who did not have diabetes mellitus and who had a contemporaneous digital mammography performed and had the appropriate laboratory data. A total of 164 women were included. Results: The mean age of the patients was 55.88±4.49 years. According to the Breast Imaging Reporting and Data System, 116 of the 164 patients (70.7%) were in the low-density group, and 28 patients (20.3%) were categorized as having a high-density result. The group with a high mammographic breast density had a significantly greater high-density lipoprotein (HDL) cholesterol level than the group with a low breast density (55.35±12.98 vs 51.14±12.38 mg/dL, respectively; p=0.035). The low-density lipoprotein cholesterol level of the high-density tissue group was greater than that of the low-density group, but was not statistically significant (146.5±37.22 vs 133.73±33.97 mg/dL, respectively; p=0.052). Conclusion: It was determined that a high HDL cholesterol level and older age were associated with breast density. There is a need for prospective, large-scale studies in this area.

Lipid biomarkers and Cancer risk - a population-based prospective cohort study in Taiwan

“…Furthermore, the influence of LDL-C on cancer development may differ among various site-specific malignancies. While some studies found that low LDL-C levels may increase risk for hematological and esophageal cancers [ 34 , 35 ], other studies reported marginal or non-significant association between LDL-C levels and the risk of breast cancer [ 36 , 37 ]. The cholesterol requirement and basic constitution vary in different tissues; thus, the tissue origin of the neoplasm may also lead to discrepant observations [ 38 ].…”