The influence of some factors on local control of early glottic cancer

Krawczyk, J.; Svoboda, V.; Foster, L. Bryant

doi:10.1016/s0936-6555(05)80588-6

Cited by 16 publications

(3 citation statements)

References 19 publications

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“…Several investigators have reported that OTT is a strong prognostic factor in T2 laryngeal carcinoma 5,14–17 . However, few investigators have reported that OTT is a significant prognostic factor in T1 laryngeal carcinoma 17 . In the present study, OTT was not a significant prognostic factor for local control either in T1a or in T1b glottic carcinoma.…”

Section: Discussioncontrasting

confidence: 59%

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Long‐Term Results of Radiotherapy for T1a and T1bN0M0 Glottic Carcinoma

et al. 2008

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Long‐Term Results of Radiotherapy for T1a and T1bN0M0 Glottic Carcinoma

et al. 2008

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“…Series with sample sizes similar to ours report figures of 90–97% for T 1 and 92–96% for T 2 . 1,28–30 …”

Section: Discussionmentioning

confidence: 99%

Early glottic carcinoma: Results of treatment by radiotherapy

Smee¹,

Bridger

Williams³

et al. 2000

Australasian Radiology

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The purpose of the present paper was to review the results of treating early (stages T1-2N0) glottic, squamous cell carcinoma by radiotherapy in the Department of Radiation Oncology, Prince of Wales Hospital, Sydney. A retrospective review was carried out of all patients seen in the department from 1967 to 1994, inclusive. To be eligible, patients had to have newly diagnosed cancer and to have been treated with curative intent by radiotherapy alone. Three hundred and sixty-nine patients satisfied the eligibility requirements. The mean follow-up time was 12.2 years (maximum: 28 years). At 5 years the actuarial local control rate was 80% (84% for stage T1 and 72% for T2). The ultimate local control rate was 96%. The overall survival rates at 5 and 10 years were 73% and 52%, respectively. The risk of nodal recurrence was much higher after persisting disease or local recurrence. Our results confirm the high cure rates achieved with this modality of treatment and are comparable with those reported in the literature.

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Therapeutic modalities and oncologic outcomes in the treatment of T1b glottic squamous cell carcinoma: a systematic review

Gioacchini

Tulli

Kaleci³

et al. 2017

Eur Arch Otorhinolaryngol

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T1a and T1b glottic squamous cell carcinoma (SCC) are often analyzed together by authors who investigate the oncologic outcomes achieved after different therapeutic options. Nevertheless, T1b definitely represents a more advanced tumor stage compared to T1a glottic SCC. The objective of this review was first to analyze the overall success rates in the treatment of patients affected by T1b glottic SCC. Moreover, a subgroup analysis was planned to specifically compare the outcomes obtained with radiotherapy (RT), transoral laser microsurgery (TLM) and open partial laryngectomies (OPL). An electronic library search of the relevant English literature was performed. Potentially eligible articles were reviewed. Qualified articles were selected and evaluated. Fifty-two studies comprising 2360 patients were included. The overall rate of disease-free survival (DFS) was 85% (95% CI 83-87). The overall rate of overall survival was 85% (95% CI 80-88) while the rate of disease-specific survival (DSS) was found to be 96% (95% CI 90-98). Statistical data concerning outcomes for each therapeutic modality showed an higher DFS rate for subjects treated with RT and OPL, respectively, 87% (95% CI 0.85-0.89) and 83% (95% CI 0.78-0.89), when compared to those who underwent TLM 77% (95% CI 0.69-0.83). In conclusion, our results showed a high level of overall DSS (96%) for patients affected by T1b glottic SCC. Regarding the specific therapeutic options, our subgroup analysis showed as patients treated with TLM present a higher rate of oncological recurrence in comparison to those who underwent RT or OPL. Nevertheless, on the basis of our data it was also noted that no significant differences subsist in terms of survival rates among the three different treatments. Moreover, the absence of a comparative analysis useful to confirm these conclusions must be considered.

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The influence of some factors on local control of early glottic cancer

Cited by 16 publications

References 19 publications

Long‐Term Results of Radiotherapy for T1a and T1bN0M0 Glottic Carcinoma

Long‐Term Results of Radiotherapy for T1a and T1bN0M0 Glottic Carcinoma

Early glottic carcinoma: Results of treatment by radiotherapy

Therapeutic modalities and oncologic outcomes in the treatment of T1b glottic squamous cell carcinoma: a systematic review

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