Long‐Term Results of Radiotherapy for T1a and T1bN0M0 Glottic Carcinoma

Nomiya, Takuma; Nemoto, Kenji; Wada, Hitoshi; Takai, Yoshihiro; Yamada, Satoshi

doi:10.1097/mlg.0b013e3181781791

Cited by 38 publications

(27 citation statements)

References 19 publications

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“…In our analysis, factors that adversely affected LC were T stage, overall treatment time exceeding 41 days, and poorly differentiated histology. Others have reported that smaller fraction size, subglottic extension, treatment delays/interruptions, age, smaller field sizes, lower total dose, gender, stage, higher beam energy, anterior commissure involvement, pretreatment hemoglobin levels, and impaired vocal cord mobility adversely affect LC (7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 96%

T1N0 to T2N0 Squamous Cell Carcinoma of the Glottic Larynx Treated With Definitive Radiotherapy

Chera

Amdur

Morris

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

154

146

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Section: Discussionmentioning

confidence: 96%

T1N0 to T2N0 Squamous Cell Carcinoma of the Glottic Larynx Treated With Definitive Radiotherapy

Chera

Amdur

Morris

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

154

146

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“…There are many cases of T1. Nomiya et al [12] reported that the 5-year survival rate was 85% and the 10-year survival rate was 73% in 115 patients with T1a laryngeal cancer, and 89% and 85%, respectively, in 48 patients with T1b. The larynx preservation rate was 92% at 5 years and 85% at 10 years in T1a patients and 85% and 76%, respectively, in T1b patients.…”

Section: Discussionmentioning

confidence: 97%

Long-term observations and salvage operations on patients with T2N0M0 squamous cell carcinoma of the glottic larynx treated with radiation therapy alone

Furusaka¹,

Matuda²,

Saito³

et al. 2012

Acta Oto-Laryngologica

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In 57 patients, we observed CR in 33 patients, partial response (PR) in 20 patients, no change (NC) in 4 patients, and progression disease (PD) in none of the patients. The response rate was 93.0% and the CR rate was 57.9%. The survival rates (Kaplan-Meier method) were: 5-year survival rate of 88.5% and 10-year survival rate of 73.5%. The larynx preservation rates (Kaplan-Meier method) were: 5-year larynx preservation rate of 60.4% and 10-year larynx preservation rate of 50.1%. The main side effect of grade 3 or more was only stomatitis in four patients, all of which were reversible changes (CTCAT v3.0 JCOG/JSCO). Salvage operation was required in 34 (59.6%) of 57 patients, 10 patients underwent partial laryngectomy, total laryngectomy was performed in 3 of the 10 patients following the partial laryngectomy, and 27 patients (47.4%) underwent total laryngectomy. The surgical specimens were serially sectioned at a thickness of 4 μm and examined histopathologically and compared to the macroscopic findings at surgery. The safe margin for partial laryngectomy was considered grossly to be 5 mm from the edge of the tumor.

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“…8 In the literature, local control of T1 glottic lesions reaches over 90%, varying according to involvement of one or both vocal folds. 9,10 Thus, local control is decreased in lesions that involve the anterior commissure (92.3% 5-year disease-free survival rate) compared to lesions only in one vocal fold (85% 5-year disease-free survival rate).…”

Section: Discussionmentioning

confidence: 99%

Avaliação da sobrevida livre de doença em pacientes com carcinoma epidermoide de laringe submetidos à tratamento radioterápico exclusivo ou associado à quimioterapia

Chedid¹,

Lehn²,

Rapoport³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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In early stage (I and II) laryngeal squamous cell carcinoma, both surgery and radiotherapy results in significant local and regional control. In advanced tumors (III and IV), radiotherapy alone has local-regional control rates of 32-43%. Aim: To assess disease-free survival in SCC laryngeal carcinoma patients submitted to radiotherapy alone and/or associated with chemotherapy. Materials and Methods: Retrospective study involving 84 cases of laryngeal SCC treated with radiotherapy or chemotherapy together with radiotherapy. Fifty-three cases were treated with intension to cure and 31 because of impossibility to resect the disease. As to clinical stage (CS), 12 were CS I, 15 II, 21 III and 5 IV. In the second group, 11 cases were EC III and 20 IV. Results: Mean age was 60 years, 84.5% were men. Fifty-eight (69.1%) cases had complete response and 26 (30.9%) had persistent or residual disease. Five-year disease-free survival was of 42.5%; 62.5% of the patients with organ preservation indication and 9.75 in the group of irressecable disease. Conclusion: disease-free survival of those patients submitted to radiotherapy because of laryngeal SCC was of 62.5%

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Long‐Term Results of Radiotherapy for T1a and T1bN0M0 Glottic Carcinoma

Abstract: Radiotherapy with a total dose of 67 to 70 Gy seemed to be required for local control in T1b glottic carcinoma. No significant benefit of total radiation dose > 64 Gy was shown in the analysis of T1a glottic carcinoma.

Cited by 38 publications

References 19 publications

T1N0 to T2N0 Squamous Cell Carcinoma of the Glottic Larynx Treated With Definitive Radiotherapy

T1N0 to T2N0 Squamous Cell Carcinoma of the Glottic Larynx Treated With Definitive Radiotherapy

Long-term observations and salvage operations on patients with T2N0M0 squamous cell carcinoma of the glottic larynx treated with radiation therapy alone

Avaliação da sobrevida livre de doença em pacientes com carcinoma epidermoide de laringe submetidos à tratamento radioterápico exclusivo ou associado à quimioterapia

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