The influence of sodium hypochlorite and chlorhexidine on postoperative pain in necrotic teeth: a systematic review

Abstract

Objective: The purpose of this systematic review was to provide the answer to the question: Can sodium hypochlorite and chlorhexidine influence postoperative pain after the endodontic treatment in necrotic teeth? Methods: The PROSPERO registration number is CRD42018096433 and was conducted following the PRISMA statements. The MeSH and free terms were used to search for articles published in the electronic databases (PubMed, Web of Science, Scopus, Cochrane Library, and Virtual Health Library), in the gray literature, and by a manual search. The reviewers selected the studies considering predetermined eligibility criteria, performed data extraction, and evaluated the risk of bias. Only clinical trials comparing the effect of sodium hypochlorite and chlorhexidine on postoperative pain in teeth of adult patients with necrotic pulps were included. Results: Five studies were qualified for the systematic review. Two studies were considered a low risk of bias. The results showed no statistically significant difference regarding postoperative pain in the groups. Only 1 study reported a statistically significant difference in the sixth postoperative hour, and the pain was associated with the sodium hypochlorite group. Conclusion: There was no influence of auxiliary chemical substance (NaOCl and CHX) on postoperative pain used in endodontic treatment in the teeth with pulp necrosis. However, one study observed a significant difference in the sixth postoperative hour, associated with the sodium hypochlorite group.

Outcomes reporting in systematic reviews on non‐surgical root canal treatment: A scoping review for the development of a core outcome set

“…In total, 149 reviews were eligible for full‐text review, 74 were excluded for various reasons (Table S2). The included studies comprised 75 systematic reviews, of which 40 included meta‐analyses (Table 3); (Abdulrab et al, 2018; Almeida et al, 2017; Alonaizan & AlFawaz, 2019; Aminoshariae et al, 2017; Aminoshariae et al, 2020; Aminoshariae & Kulild, 2015; Aminoshariae & Kulild, 2020; Anagnostaki et al, 2020; Basmadjian‐Charles et al, 2002; Bergenholtz et al, 2013; Bordea et al, 2020; Borges Silva et al, 2017; Borgo Sarmento et al, 2020; Căpută et al, 2019; Chércoles‐Ruiz et al, 2017; Chrepa et al, 2014; Cope et al, 2014; Cope et al, 2018; Cunha et al, 2020; Decurcio et al, 2019; Del Fabbro et al, 2007; Del Fabbro et al, 2016; Del Fabbro et al, 2018; Fedorowicz et al, 2012; Figini et al, 2007; Fransson et al, 2013; Gillen et al, 2011; Gupta et al, 2020; Hou et al, 2017; Iqbal & Kim, 2007; Jamali et al, 2018; Kang et al, 2015; Kojima et al, 2004; Kruse et al, 2015; Leong et al, 2020; Leong & Yap, 2019; Manfredi et al, 2016; Martins et al, 2020; Matthews et al, 2003; Mello et al, 2019; Moreira et al, 2019; Nagendrababu et al, 2019; Nasrabadi et al, 2020; Neelakantan, Ahmed, et al, 2019; Neelakantan et al, 2020; Neelakantan, Herrera, et al, 2019; Ng et al, 2007; Ng et al, 2010; Ng, Mann, & Gulabivala, 2008; Ng, Mann, Rahbaran, et al, 2008; Nixdorf et al, …”

“…The included studies comprised 75 systematic reviews, of which 40 included meta-analyses (Table 3); (Abdulrab et al, 2018;Almeida et al, 2017;Alonaizan & AlFawaz, 2019;Aminoshariae et al, 2017;Aminoshariae & Kulild, 2015;Anagnostaki et al, 2020;Basmadjian-Charles et al, 2002;Bergenholtz et al, 2013;Bordea et al, 2020;Borges Silva et al, 2017;Borgo Sarmento et al, 2020;Căpută et al, 2019;Chércoles-Ruiz et al, 2017;Chrepa et al, 2014;Cope et al, 2014;Cope et al, 2018;Cunha et al, 2020;Decurcio et al, 2019;Del Fabbro et al, 2007;Del Fabbro et al, 2016;Del Fabbro et al, 2018;Fedorowicz et al, 2012;Figini et al, 2007;Fransson et al, 2013;Gillen et al, 2011;Gupta et al, 2020;Hou et al, 2017;Iqbal & Kim, 2007;Jamali et al, 2018;Kang et al, 2015;Kojima et al, 2004;Kruse et al, 2015;Leong et al, 2020;Leong & Yap, 2019;Manfredi et al, 2016;Martins et al, 2020;Matthews et al, 2003;Mello et al, 2019;…”

Effect of photobiomodulation on post‐operative symptoms in teeth with asymptomatic apical periodontitis treated with foraminal enlargement: A randomized clinical trial

“…Cruz Júnior et al (2016) and Coelho et al (2019) used 40 mL of 2.5% NaOCl, while the present study used 15 mL, this difference may have influenced the disinfection of teeth with apical periodontitis and, consequently, the occurrence of pain and tenderness. However, it is worth mentioning that a recent systematic review concluded that the irrigant had no influence on post‐operative pain (Borgo Sarmento et al, 2020), possibly determining that foraminal enlargement may have been the factor for the progression of post‐operative symptoms on the days evaluated (Borges Silva et al, 2017).…”

Investigação Das Intervenções Do Enfermeiro Nos Cuidados Aos Idosos Com Doenças Crõnicas Não Transmissíveis

“…Surgiu no final da década de 40, mas só em 1959 manifestou-se na odontologia como substância segura, a ser aplicada no controle do biofilme dental. Tem como finalidades na endodontia, ser um agente antimicrobiano no decorrer das etapas de irrigação e instrumentação do SCR, desinfeção do campo operatório, erradicação dos tecidos necróticos, PQM antes da desobstrução, medicação intracanal, desinfeção e remoção dos cones de guta percha nos retratamentos (Gomes et al, 2013;Sarmento, Guimaraes, & Gomes, 2020).…”