The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide Extended Release Matrices

Palmer, Dasha; Levina, Marina; Nokhodchi, Ali; Douroumis, Dennis; Farrell, Tom; Rajabi‐Siahboomi, Ali R.

doi:10.1208/s12249-011-9648-4

Cited by 51 publications

(25 citation statements)

References 43 publications

(50 reference statements)

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“…In addition to regular beneficial effects of hydrogel relating to sustained or controlled release delivery and solute permeability [4,15], NaCMC hydrogel as a type of intelligent (smart) hydrogel looks very promising in drug delivery and shows some distinctive characteristics, including compatibility with many loaded chemicals [14,27]. It was found [35] that release of anionic and non-ionic loaded drugs from polyanionic NaCMC matrix is usual, but it is significantly extended for cationic drugs because of chemical bonds between these drugs and carboxyl groups in the dissolution medium. Therefore, this type of hydrogel can be used for designing novel prolonged release matrices for cationic chemicals.…”

Section: Discussionmentioning

confidence: 99%

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Polymeric Nanostructures as Colloidal Drug Delivery Systems: Thermosensitive Hydrogels Containing Self-Assembled Micelles

Hossein¹

2015

J Nanomed Nanotechnol

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Polymeric nanostructures for drug delivery applications including smart hydrogels and stealth micelles have been developed to overcome many obstacles in the way of timing and targeting the delivery to fulfill therapeutic potentiality of chemicals. The purpose of this investigation is to prepare and characterize novel nanoparticle-based colloidal products composed of biocompatible polymers to use for rate-controlled release and targeted/spatial drug delivery systems, aiming specifically at drug delivery via mucosal routes. We formulated the new products with inert and biocompatible polymers including sodium carboxymethylcellulose (NaCMC) and polysorbates. The synthesis process was performed by heating/cooling method, as a type of physical cross-linking method for producing hydrogel, in three steps to optimize physical and chemical characteristics of the products to make them suitable for delivery through mucosal routes. A series of nanoparticle-based colloidal products in the form of liquid suspensions were developed, and from all three steps, thirty-nine samples were selected and rheologically investigated by bench-top experiments. A freeze-thawing method was applied to two samples of product III10 for five and one repeated cycles sequentially. Test tube inversion method was also carried out on all the produced gels. Most of the products are new types of temperaturesensitive, smart, physically self-assembled hydrogels and took the forms of sol, gel (opaque and transparent), and precipitate. However, these hydrogels show opposite gelation property to customary temperature-sensitive gels. The product of five repeated freezing-thawing cycles is also thermoreversible gel with a high mechanical stability and swelling capacity, as opposed to the product of one cycle. Some types of produced hydrogels behave like a ternary system. The products of this work, with microstructure consisting of the polymeric chains of sodium carboxymethylcellulose and a large-scale self-assembly of micellar structures of polysorbates incorporated within a polymer network, show major efficacy of site-specific and controlled release drug delivery system.

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Section: Discussionmentioning

confidence: 99%

“…It is known [38] that polysorbates, as nonionic surfactants, adsorb to the NaCMC molecules in solution and form polymer complex. Bonding between the polyoxyethylene (POE) segment of polysorbates and the NaCMC hydrogel improves biocompatibility and biodistribution of the gel matrix and reduces the initial burst effect [24,35].…”

Section: Discussionmentioning

confidence: 99%

Polymeric Nanostructures as Colloidal Drug Delivery Systems: Thermosensitive Hydrogels Containing Self-Assembled Micelles

Hossein¹

2015

J Nanomed Nanotechnol

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“…The two tablet formulations were tested with 5 and 40% ethanol in water for 12 h and with exposure to the same alcohol solutions for 1 h followed by dissolution with water ( Fig. 29) (Palmer et al 2011). The f 2 similarity results indicate that the dissolution profiles were not impacted by ethanol exposure in all conditions except the metformin in 40% ethanol for 12 h. In this case, the release profile was reduced indicating a resistance to alcohol dose dumping.…”

Section: Polyethylene Oxide Extended-release Matrix Tabletsmentioning

confidence: 95%

A review of in vivo and in vitro aspects of alcohol-induced dose dumping

D’Souza

Mayock

Salt³

2017

AAPS Open

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This review provides a comprehensive list of in vivo and in vitro studies that have investigated alcohol induced dose dumping (AIDD) in modified release dosage forms. Of the numerous classes of drugs commercially available as modified release products, opioids, centrally acting drugs, and drugs with a narrow therapeutic index present high risks from dose dumping, despite being formulated in a manner that releases drug in a tailored or delayed fashion. Awareness of AIDD has led to the withdrawal of a few marketed products by Regulatory Agencies, and black box warnings on others. Since then, significant effort has focused on proving the robustness of a formulation when co-ingested with alcohol. Patient risk is deemed to be low if the formulation and its performance is unimpaired by the presence of 0-40% alcohol under in vivo and in vitro conditions.

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“…The polymers are widely used in the preparation of controlled release matrices due to their simplicity, safety and it should be economical use [1][2][3][4]. Among these polymers celluloses have been extremely popular in controlling the release rate of soluble drug from solid dosage form.…”

Section: Introductionmentioning

confidence: 99%

“…Among these polymers celluloses have been extremely popular in controlling the release rate of soluble drug from solid dosage form. The ease of compression, their ability to accommodate large amount of drugs and the minimum processing variables on the release rate are the main reasons for their popularity [1][2]. Sodium carboxymethylcellulose is a widely used polymer, due to its availability in a range of viscosity grades and good swelling and erosion characteristics, which can be used to modulate the release of various drugs [5 -10].…”

Section: Introductionmentioning

confidence: 99%

The influence of the composition and charges of the acrylic resins, the hydrophilic polymer, and the other excipients on the release rate of drug from the matrices.

Alhmoud¹

2016

Adv. Biomed. Pharma.

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The effect of the hydrophilic polymers such as sodium carboxymethyl cellulose, (NaCMC) and the hydrophobic polymers such as Eudragit RL100 and Eudragit RS 100 on the dissolution and the release rate of drug when prepared as controlled release matrices were studied. Tablets were prepared by a direct compression technique. The dissolution tests were performed by both the basket and the paddle methods. In the present study the acrylic resins Eudragit RS 100 and Eudragit RL 100 are separately mixed with the anionic and hydrophilic polymer NaCMC and the other excipients in an attempt to prepare controlled release matrices and to investigate the effect of the charge and composition of these polymers on the drug release. Also the research will study the effect of the pH of the dissolution medium, and the storage of the matrices at different temperatures, on the release rate of the drug. It was found that percent, charge of the polymers, pH of the dissolution medium and storage of matrices at different temperatures affect the release rate of the drug. The experiments were performed in vitro and the data obtained were plotted according to four kinetic models to study the release kinetic. These models were zero order release, first order release, Higuchi equation, and Korsmeyer equation. Zero order release was observed in the formulation with a high percent of the hydrophilic polymers, while high percent of hydrophobic polymers didn't show zero order release and the drug was liberated in a less time from the matrices.

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The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide Extended Release Matrices

Cited by 51 publications

References 43 publications

Polymeric Nanostructures as Colloidal Drug Delivery Systems: Thermosensitive Hydrogels Containing Self-Assembled Micelles

Polymeric Nanostructures as Colloidal Drug Delivery Systems: Thermosensitive Hydrogels Containing Self-Assembled Micelles

A review of in vivo and in vitro aspects of alcohol-induced dose dumping

The influence of the composition and charges of the acrylic resins, the hydrophilic polymer, and the other excipients on the release rate of drug from the matrices.

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