The Influence of Silica Nanoparticles on Small Mesenteric Arterial Function

Shukur, Ali; Whitehead, Debra; Seifalian, Alexander M.; Azzawi, May

doi:10.2217/nnm-2016-0124

Cited by 8 publications

(4 citation statements)

References 46 publications

(41 reference statements)

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“…We measured relative fluorescence levels in solution using the DCF assay which cannot be used as a direct measure of hydrogen peroxide and other ROS moieties [36; 37]. intravenous administration [5]. No uptake was evident when SiNPs were added to vessels at 4 o C [12].…”

Section: Discussionmentioning

confidence: 99%

“…Hence, there is an urgent need for early therapeutic intervention strategies to preserve and restore vessel health. We have previously demonstrated the uptake of nanomaterials by ECs [5,6], including mesoporous silica nanoparticles (MSNs), and their highlighted potential use as drug delivery platforms for vasodilator drugs [7]. In particular, MSNs hold great promise as drug delivery vehicles [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…This can be especially attractive for targeted delivery of vasodilator drugs for subjects with CVD. However, despite such potential uses, silica nanoparticles have previously been shown to affect vascular function, depending on their surface charge, dye doping and size [5,12,13]. Silica nanoparticles (SiNPs) can generate reactive oxygen species (ROS), such as hydroxyl radical ( • OH), superoxide anion (  _ 2 O ) and hydrogen peroxide (H2O2), causing an imbalance between the oxidant and antioxidant processes, thus leading to intracellular oxidative stress [14].…”

Section: Introductionmentioning

confidence: 99%

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Titania coating of mesoporous silica nanoparticles for improved biocompatibility and drug release within blood vessels

et al. 2018

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Cardiovascular disease is a major cause of mortality and morbidity worldwide, with a total global cost of over $918 billion, by 2030. Mesoporous silica nanoparticles (MSNs) have great potential for the delivery of drugs that can treat vessel disease. This paper provides the first description for the use of titania coated MSNs with increased vascular penetration, for the delivery of vasodilator drugs, without compromising overall vessel function. We demonstrate that titania coating of MSNs significantly improves their biocompatibility and uptake within aortic blood vessels and furthermore, enables a slower and more sustained release of the vasodilator drug, sodium nitroprusside within the vessel, thus making them an attractive strategy for the treatment of vascular disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Titania coating of mesoporous silica nanoparticles for improved biocompatibility and drug release within blood vessels

et al. 2018

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“…While the potential use of nanoparticles in cancer therapy and diagnostics is clearly realized, Shukur and colleagues illustrate the dosage-dependent influence of nanoparticles on arterial function, which highlights the need to assess nanomaterial biocompatibility for maintaining vasodilation (hence organ perfusion) when administered intravenously and help identify strategies for their safe clinical administration [12]. Finally, the review article by Sivakumaran and colleagues highlights the paramount importance for accurate characterization of nanomaterials that are used in clinical diagnosis and therapeutics in order to realize the full potential of nanotechnology in medicine [13].…”

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confidence: 99%

Nanotechnology for the Diagnosis and Treatment of Diseases

Azzawi

Seifalian

Ahmed

2016

Nanomedicine (Lond.)

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This special issue of Nanomedicine was compiled after the 3rd International Conference on Nanotechnology in Medicine, held in Manchester, UK, in November 2015. It brought together international scientists and clinicians from multidisciplinary backgrounds and specialities to share a common interest in pushing the boundaries of our current understanding of the field of nanomedicine. This special issue focuses on key areas in the application of nanotechnology, with the aim of highlighting recent advances and developments to realize the full potential of nanomedicine.\ud \ud Targeted drug delivery is a key application of nanotechnology in medicine that has gained a plethora of interest. While Feczko and colleagues illustrate the potential use of IFN-α drug-loaded nanocomposites as a potential tool for intravenous controlled release drug delivery [1], Quignard and colleagues formulated nanometric oil droplets for encapsulating solid nanoparticles as a way of modulating their internalization pathway and enhance intracellular delivery [2]. An important advancement in the area of drug delivery is the use of triggered response nanoparticulate systems. These include the use of a bioinspired mineralization process and superparamagnetic hybrid nanobeads. The work by Campodoni and colleagues provides a good example of performing such magnetic functionality [3]. They synthesized superparamagnetic hybrid nanobead hydroxyapatite composite material as a drug carrier system, with the ability of remote activation by a magnetic signal. This unique multifunctional drug delivery system is bioresorbable and biocompatible, holding promise for smart applications in nanomedicine, including active targeting and therapeutic purposes. An emergent technology in inhalation therapy is the use of targeted liposomes which has the potential of improving pulmonary delivery of drugs such as corticosteroids for patients with chronic asthma. Altube and colleagues synthesized pH-sensitive archeosomes which are lipid vesicles extracted from archaebacterial that have the property of resistance to lipolytic enzymes [4]. These were loaded with dexamethasone as a model drug. The resultant nanoliposomes exhibited new pharmacodynamic properties with increased mechanical properties during nebulization, highlighting the potential of this novel concept.\ud \ud Another key application of nanotechnology in medicine, enabled by advances in targeted drug delivery, is in therapeutics, in particular, cancer therapy. The review article by Karponis and colleagues illustrates the theranostic properties of magnetic nanoparticles as a promising candidate for the targeting and treatment of cancer [5]. This work was presented as a keynote lecture at the conference. Other nanoparticles, in particular, gold nanoparticles, also show significant potential as theranostic agents which integrate both diagnostic and therapeutic properties. Butterworth and colleagues illustrate clearly this concept in the simultaneous diagnosis and therapy of prostate cancer [6]. Using thiol stabiliz...

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