Titania coating of mesoporous silica nanoparticles for improved biocompatibility and drug release within blood vessels

Abstract

Cardiovascular disease is a major cause of mortality and morbidity worldwide, with a total global cost of over $918 billion, by 2030. Mesoporous silica nanoparticles (MSNs) have great potential for the delivery of drugs that can treat vessel disease. This paper provides the first description for the use of titania coated MSNs with increased vascular penetration, for the delivery of vasodilator drugs, without compromising overall vessel function. We demonstrate that titania coating of MSNs significantly improves their biocompatibility and uptake within aortic blood vessels and furthermore, enables a slower and more sustained release of the vasodilator drug, sodium nitroprusside within the vessel, thus making them an attractive strategy for the treatment of vascular disease.

Bio-Mediated Synthesis and Characterisation of Silver Nanocarrier, and Its Potent Anticancer Action

“…Kinetics assesments suggest that the drug were released through both diffusion and erosion controlled (non-fickian) method because the release data can be fitted into Higuchi and Korsmeyer-Peppas models [61]. Dissolution-filling approach occurred as PCA gradually released and diffused from the NPs that act as the carriers [62].…”

Tetramethoxystilbene-Loaded Liposomes Restore Reactive-Oxygen-Species-Mediated Attenuation of Dilator Responses in Rat Aortic Vessels Ex vivo

“…The aortic vessel was gently pinned down at both ends and the underlying adipose tissue was removed using dissection scissors and forceps under a binocular dissection microscope with a fibre optic light source (Olympus SZ61). The vessel was then cut into 3 mm rings and mounted between two fine steel wires in a calibrated organ-bath system, immersed in oxygenated PSS at 35 °C, and then placed under 2 g tension using a Harvard isometric strain transducer and tension was recorded using Labchart 8 (Power lab, AD Instruments, Oxford, UK), as previously described [29]. The viability of blood vessels was examined by ascertaining initial responses to high potassium solution (KPSS, 60 mM).…”

Obtención, funcionalización y aplicaciones biomédicas de las Nanopartículas de Sílice Mesoporosa: una revisión

“…Farooq et al [14] y Hu et al [37], reportaron las síntesis de MSN utilizando el método dirigido por la plantilla tensioactiva seguido de la eliminación de la plantilla CTAB. Guo et al [38], sintetizaron MSN dopados con estroncio (Sr) mediante un método de plantilla mediado por CTAB.…”

“…Tsamesidis et al [3], doparon NPs con iones como Ca, Mg y Cu para mejorar la biocompatibilidad, los resultados mostraron que las tasas de hemolisis disminuyeron lo que sugiere un efecto protector de los SN dopados con iones en la membrana de los eritrocitos en comparación con las NPs puras. Farooq et al [14], utilizaron Titania usando la técnica de deposición física de vapor de pulverización reactiva con magnetrón para mejorar la y dinámica de liberación de un fármaco vasodilatador cargado en MSN.…”

“…La superficie de las MSN puede ser modificada mediante varias estrategias, con grupos funcionales y ligandos para mejorar sus propiedades fisicoquímicas y su respuesta a estímulos magnéticos, térmicos, fotoestímulos, campos magnéticos y eléctricos, pH, agentes redox y ultrasonido [1,7]. Con las funcionalizaciones y/o recubrimientos apropiados, estas nanopartículas mejoran su rendimiento, pueden ser absorbidas por células no fagocíticas y luego pueden liberar moléculas encapsuladas en la ubicación deseada [11,14].…”