The influence of short‐term diabetes mellitus and insulin therapy on alveolar bone loss in rats

Holzhausen, Marinella; D, Garcia; Pepato, Maria Teresa; Marcantônio, Élcio

doi:10.1111/j.1600-0765.2004.00723.x

Cited by 48 publications

(62 citation statements)

References 56 publications

(61 reference statements)

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“…Insulin treatment significantly reduced glucose levels. However, glucose levels were not decreased to the levels documented in previous studies, 19,21 despite daily adjustment of the insulin dosage.…”

Section: Discussionmentioning

confidence: 74%

“…Diabetes induction was confirmed in rats 2 19 and 3 21 days after STZ injection. In the present study, day 5 was selected as the cut-off day.…”

Section: Discussionmentioning

confidence: 76%

“…Type 1 diabetes was induced by the intravenous injection (into the tail vein) of streptozotocin (STZ) (Sigma, St. Louis, USA), 45 mg/kg body weight, 20 dissolved in citrate buffer (10 mM, pH 4.5). Rats with glucose levels > 300 mg/dL 19,21 up to the 5 th day were included in the study. Body weight and blood glucose were measured daily 19 (glucometer Wellion  Linus, AgaMatrix Inc., Salem, USA) after a 12-hour nocturnal fast.…”

Section: Methodology Animalsmentioning

confidence: 99%

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Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

et al. 2012

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The aim of the study was to compare the serum levels of adiponectin and interleukin-6 (IL-6) in insulin-treated diabetic rats with or without periodontitis. Forty male Wistar rats were randomly divided into 2 groups (20 rats each): a) insulin-treated diabetic group (control, DI) and b) insulin-treated diabetic periodontitis group (test, DIP). Diabetes was induced, and insulin treatment was initiated on day 5. On day 16, periodontitis was induced in the DIP group. All rats were euthanized on day 77. Adiponectin and IL-6 were assessed on days 16 and 77. At the end of the experiment, 14 and 11 rats survived in the DI and DIP groups, respectively. Adiponectin levels were statistically significantly higher at the end of the experiment compared with levels on day 16 in the periodontitis group (p < 0.05), but not in the control group. At the end of the experiment, adiponectin levels were statistically significantly higher in the periodontitis group compared with the control group (p < 0.05). Within-group and between-group comparisons of IL-6 levels showed no statistically significant difference. In conclusion, serum adiponectin was increased in insulin-treated diabetic rats with periodontitis in comparison with insulin-treated diabetic rats, while IL-6 levels did not differ between groups.

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Section: Discussionmentioning

confidence: 74%

“…Diabetes induction was confirmed in rats 2 19 and 3 21 days after STZ injection. In the present study, day 5 was selected as the cut-off day.…”

Section: Discussionmentioning

confidence: 76%

Section: Methodology Animalsmentioning

confidence: 99%

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Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

et al. 2012

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“…Association between periodontal disease and DM is well documented. Holzhausen et al 11 observed that hyperglycemia may interfere with the periodontal disease because it leads to an exaggerated inflammatory response and impaired healing. The present study shows a significant correlation between high blood sugar levels and stress.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Psychological Stress and Serum Cortisol in Patients having Chronic Periodontitis with and without Type II Diabetes Mellitus: A Clinicobiochemical Study

Byakod¹,

Rajhans²,

Kumar³

et al. 2017

World Journal of Dentistry

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“…Ancak, glisemik kontrol olmayan "diyabetli" ve sistemik olarak sağlıklı "diyabetsiz" gruplar arasında önemli fark olmadığı rapor edilmiştir. 30 Bu araştırmada da benzer olarak streptozotosin ile diyabet oluşturulan ve diyabet oluşturulmayan sıçanların tamamının molar dişlerine 3/0 ipek sütur bağlanarak deneysel periodontitis oluşturulmuştur. Üç haftalık çalışma sonunda alınan kesitlerde histometrik olarak AKK değerlendirilmiş ve diyabet olan ve olmayan gruplarda AKK ölçümleri benzer bulunmuştur.…”

Section: ö Z E Tunclassified

Deneysel periodontitis oluşturulmuş diyabetik sıçanlarda α-tokoferol’ün alveoler kemik kaybı üzerine etkileri

Hatipoğlu¹,

Alptekin²,

Avunduk³

2014

Cumhuriyet Dent J

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A B S T R A C TObjectives: A variety of clinical and experimental studies investigated the influence of diabetes on the periodontium, as well as the impact of periodontitis on diabetes status. The aim of this study was to investigate the effects of α-tocopherol on alveolar bone loss in rats with experimental periodontitis with/without streptozotocin (STZ)-induced diabetes. Materials and Methods: Forty male Sprague Dawley rats were included in the study and after anesthesia 3/0 silk sutures were placed at the subgingival level of the mandibular right first molars. These animals were divided into two groups: Healty group (Group I) and diabetic group by single injection of 50 mg/kg STZ (Group II). These groups divided into two subgroups; twenty rats were saline group (Group IA, Group IIA) and other twenty rats (Group IB, Group IIB) were α-tocopherol (40mg/kg/day) group. After 3 weeks, all rats were sacrified and the tissues were fixed using neutral buffered 10% formaldehyde solution for histometrical investigation. Alveolar bone loss (ABL), were analyzed by using image analysis program. Statistical comparisons were performed by using one-way analysis of variance with significance set at p<0.05. Results: Data were evaluated after the histometrical examination and there were no statistically significant differences in ABL between the study groups (p>0.05). Conclusions:Analysis of these data demonstrated that α-tocopherol treatment was not affected the ABL of rats with experimental periodontitis with/without STZ-induced diabetes.

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The influence of short‐term diabetes mellitus and insulin therapy on alveolar bone loss in rats

Abstract: Within the limits of this study, it can be suggested that the severity of periodontal disease was not affected by short-term diabetes, and that experimental periodontitis increased blood glucose levels in uncontrolled diabetic rats.

Cited by 48 publications

References 56 publications

Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

Assessment of Psychological Stress and Serum Cortisol in Patients having Chronic Periodontitis with and without Type II Diabetes Mellitus: A Clinicobiochemical Study

Deneysel periodontitis oluşturulmuş diyabetik sıçanlarda α-tokoferol’ün alveoler kemik kaybı üzerine etkileri

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