The Influence of Psychocurative on Cortisol Level, Anxiety, and Quality of Life in Advanced Stage Cervical Cancer Patients

Abstract

Every year, there are 500.000 new cases and more than 250.000 deaths caused by cervical cancerworldwide. Cervical cancer patients faced physical and psychological problems several times that it activate stress mechanism such as hypothalamus-pituitary-adrenal (HPA) axis. These recurrent activations caused HPA axis disruption and adverse clinical effects. Several symptoms of endocrine stress response are the change of circadian cortisol rhythm. Cortisol is known as a stress hormone that involves an organism's response to stress and anxiety that influence the quality of life. This research aims to analyze the differences among serum cortisol level, anxiety, and quality of life in cervical cancer patients before and after psychocurative intervention in obstetrics and gynecology wards and polyclinic in RSUD Dr. Moewardi Surakarta. This research is an experimental double-blind randomized controlled clinical trial pre-test post-test group design study. The subjects were advance stage (IIB-IV)cervical cancer patients. The subjects were randomly chosen into fifteen subjects that given standard therapy and psychocurative, while the other fifteen subjects as a control only got standard therapy. Data were obtained from measurement of serum cortisol level, anxiety questionnaire DASS 42 and WHO quality of life questionnaire. Data were analyzed using SPSS 21 using difference test. The difference mean test result of cortisol serum level, anxiety, quality of life from the controlled group and uncontrolled group showed a significant difference (p < 0.05). In conclusion, psychocurative is significant to reduce cortisol level, anxiety, and improve the quality of life in advanced stage cervical cancer patients.

Correlation between High Serum Uric Acid Levels with Occurrence of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes

“…The correlation test results showed that there was a correlation between the duration of DMT2 and the incidence of diabetic peripheral neuropathy (p=0.000; odds ratio 0.038; 95% CI 0.005-0.271). This was consistent with some studies obtained a correlation between the duration of DM and diabetic neuropathy 16 . Research conducted by Fatkhur et al stated that the longer the patient suffering from DM, the risk of diabetic neuropathy was 16.7787 times greater in DM ≥5 years (p = 0.000).…”

Existing psychological supportive care interventions for cervical cancer patients: a systematic review and meta-analysis

“…The sample size ranges from a minimum of 30 [ 24 , 35 ] to a maximum of 417 [ 6 ]. An equal sample size was used in the treatment and control group in 16 studies and an unequal sample size was used in 10 studies.…”

“…Regarding treatment trajectory, nine studies included patients receiving surgical treatment [ 6 , 25 , 27 , 32 – 34 , 36 , 44 , 46 , 48 ], seven studies included patients receiving chemotherapy [ 23 , 24 , 28 , 30 , 35 , 41 , 42 ], three studies included patients receiving surgery plus chemotherapy [ 26 , 40 , 47 ], two studies included patients receiving concurrent radio chemotherapy [ 37 , 39 ], two studies included patients receiving neoadjuvant chemotherapy [ 38 , 45 ], one study included patients receiving comprehensive anti-cancer treatment [ 43 ], one study included patients completed the definitive treatment of cervical cancer before two months [ 29 ] and one study included patients they had just get a diagnosis of cervical cancer and before starting of cancer treatment [ 31 ].…”

“…Chinese herbal medicine and psychological care were used in two studies [ 26 , 47 ]. Other interventions used in this review were: whole-course high-quality care [ 43 ], case management [ 37 ], drug therapy [ 6 ], psycho-curative [ 24 ], telephone counselling [ 29 ] and peer education [ 23 ]. One paper used drugs as psychological intervention for the management of anxiety and depression [ 6 ].…”

Association between Dose and Duration of Cisplatin Exposure with Sitotoksisity Effect on Nasopharyngeal Carcinoma Stem Cell

“…Research that correlated the role of resistant cancer stem cells to cisplatin and the progression of many malignancies were included in ca mammae studies was reported that the presence of tumor cells were expressing the normal tumorigenic stem cell characteristics by 5.9% of the tumor cell population 3 . The population of these cells significantly increased to an average of 8.8% in primary transplants that only responded partially to cisplatin, while in secondary tumor transplants, the population increased to 22.8% 4 .…”