The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-β-cyclodextrin

Mura, Paola; Faucci, Maria Teresa; Bettinetti, Giampiero

doi:10.1016/s0928-0987(01)00093-8

Cited by 147 publications

(80 citation statements)

References 14 publications

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“…Specifically, Sethia and Squillante [21] found a linear correlation between the solubility of carbamazepine and the concentration of PVP k25 and PVP k30. Similar behaviour was presented by Mura et al [22] and Bettinetti and Mura [23] for Naproxen-PVP, evaluating in parallel the presence of cyclodextrin systems. Mura et al [24] investigating Naproxen-Chitosan systems found that the drug solubility was increased as the polymer concentration increased, and a type A N , according to Higuchi and Connors equation was obtained.…”

Section: Solubility In Water At 37°csupporting

confidence: 83%

Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone

Karavas

Ktistis

Xenakis

et al. 2006

European Journal of Pharmaceutics and Biopharmaceutics

138

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Solid dispersion systems are widely investigated for the dissolution enhancement of poorly water soluble drugs. Nevertheless, very limited commercial use has been achieved due to the poor predictability of such systems caused by the lack of a basic understanding of the dissolution optimization mechanism. In the present study an investigation of the release mechanism is performed for solid dispersion systems composed by polyvinylpyrrolidone (PVP) and felodipine (FEL), based on a correlation of their hydrophilicity with the intensity of interactions. The existing interactions were evaluated by using NMR and UV spectroscopy while molecular simulation techniques were also enabled. It was found that the interactions that take place correspond to the creation of hydrogen bonds. The correlation between the intensity of interactions and the concentration of PVP in the matrix showed a sigmoid function. The interactions are impressively increased for polymer concentration exceeding 75% (w/w). This phenomenon was well explained by using the molecular simulation technique. A similar sigmoid pattern was found for the function between dissolution profiles and polymer concentration in the matrix, indicating that the intensity of interactions promotes the dissolution enhancement. Investigation of the solubility and the particle size distribution of FEL in the binary system appeared to have similar behaviour indicating that the interactions affect the release profile through these two factors. The hydrophilicity of PVP does not significantly affect this enhancement as the contact angle was found to be linear to PVP concentration. Microscopic observation of the dissolution behaviour showed that FEL remains in fine dispersion in aqueous solution, verifying the release mechanism.

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Section: Solubility In Water At 37°csupporting

confidence: 83%

Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone

Karavas

Ktistis

Xenakis

et al. 2006

European Journal of Pharmaceutics and Biopharmaceutics

138

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“…The increased solubility reveals that there is an interaction between drugs and PVP in the solution. 23,25 The addition of PVP to ethanol + water did not affect the solubility of lamotrigine, and there is no systematic pattern for lamotrigine solubilities in ethanol + water mixtures in the presence of PVP. Diazepam solubilities were increased with an increase in PVP concentrations in the ethanol-rich region of solvent mixtures.…”

Section: Experimental Methodsmentioning

confidence: 93%

Effects of Different Concentrations of Poly(vinyl pyrrolidone) on the Solubility of Lamotrigine and Diazepam in Ethanol + Water Mixtures at 298.2 K

2009

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The effects of poly(vinyl pyrrolidone) K30 (PVP) (1) on the solubility of lamotrigine (2) and diazepam (2) at 298.2 K are reported for ethanol (3) + water (4) mixtures at five different concentrations (0.0001, 0.0005, 0.001, 0.005 and 0.01) g · mL -1 of PVP. The general version of the Jouyban-Acree model was fitted to the solubility data of each drug in a given concentration of PVP. The largest mean relative deviation (MRD) was 14 %, that is, for diazepam in the presence of (0.0005 and 0.001) g · mL -1 of PVP, and the lowest MRD was 4 % for lamotrigine in the presence of 0.01 g · mL -1 of PVP. The overall MRD for lamotrigine and diazepam was 9 %. A modified version of the Jouyban-Acree model was used to model the simultaneous effects of the ethanol and PVP on the solubility employing experimental solubility of drugs in water and ethanol in the absence of PVP. The MRDs for diazepam and lamotrigine were 23 % and 10 %, respectively, with the overall value of 17 %.

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“…In the case of inclusion complexes, in particular, the characteristic carbonyl-stretching band of drug appeared at 1729 and shifted to 1728 cm −1 for NAP/β-CD and NAP/HP-β-CD complexes, respectively, along with significantly reduced intensity of the same band. Characteristic absorption bands of the pure drug at 1604 cm [20] are maintained in NAP/β-CD with an evident reduction in intensity. Changes in the characteristic bands of pure drug confirm the existence of the complex as a new compound with different spectroscopic bands [22] 3.3.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Electrospun Thermoplastic Polyurethane Mats Containing Naproxen– Cyclodextrin Inclusion Complex

Akduman

Özgüney

Kumbasar

2014

Autex Research Journal

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Incorporation of cyclodextrins (CDs) into electrospun nanofibrous materials can be considered as potential candidates for functional medical textile applications. Naproxen (NAP) is a type of non-steroidal anti-inflammatory drug commonly administered for the treatment of pain, inflammation and fever. Drug-inclusion complex formation with CDs is an approach to improve the aqueous solubility via molecular encapsulation of the drug within the cavity of the more soluble CD molecule. In this study, NAP or different NAP-CD inclusion complexes loaded nanofibres were successfully produced through electrospinning and characterised. The inclusion complex loaded mats exhibited significantly faster release profiles than NAP-loaded thermoplastic polyurethane (TPU) mats. Overall, NAP-inclusion complex loaded TPU electrospun nanofibres could be used as drug delivery systems for acute pain treatments since they possess a highly porous structure that can release the drug immediately.

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The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-β-cyclodextrin

Cited by 147 publications

References 14 publications

Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone

Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone

Effects of Different Concentrations of Poly(vinyl pyrrolidone) on the Solubility of Lamotrigine and Diazepam in Ethanol + Water Mixtures at 298.2 K

Electrospun Thermoplastic Polyurethane Mats Containing Naproxen– Cyclodextrin Inclusion Complex

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