The influence of polyphenols on metabolic disorders caused by compounds released from plastics - Review

Żwierełło, Wojciech; Maruszewska, Agnieszka; Skórka-Majewicz, Marta; Goschorska, Marta; Baranowska-Bosiacka, Irena; Dec, Karolina; Styburski, Daniel; Nowakowska, Anna; Gutowska, Izabela

doi:10.1016/j.chemosphere.2019.124901

Cited by 66 publications

(37 citation statements)

References 170 publications

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“…Whereas the main urinary metabolite of DEP is mono-ethyl phthalate (MEP). Remarkably, the bioactivity of phthalate metabolites is superior to that of the original substance [29].…”

Section: Endocrine Disruptors In Dietmentioning

confidence: 99%

“…After ingestion, BPA is partially metabolized by the intestinal microbiota and largely absorbed in the intestinal tract [28]. BPA is transformed in the liver mainly by glucuronidation and, to a lesser extent, by sulfation, being eventually eliminated by the kidney [29]. Thus, BPA-glucuronide is the main metabolite of BPA in humans.…”

Section: Endocrine Disruptors In Dietmentioning

confidence: 99%

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Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

et al. 2020

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Endocrine-disrupting chemicals (EDCs) are exogenous substances that are able to interfere with hormone action, likely contributing to the development of several endocrine and metabolic diseases. Among them, Bisphenol A (BPA) and phthalates contaminate food and water and have been largely studied as obesogenic agents. They might contribute to weight gain, insulin resistance and pancreatic β-cell dysfunction in pregnancy, potentially playing a role in the development of pregnancy complications, such as gestational diabetes mellitus (GDM), and adverse outcomes. Pregnancy and childhood are sensitive windows of susceptibility, and, although with not univocal results, preclinical and clinical studies have suggested that exposure to BPA and phthalates at these stages of life might have an impact on the development of metabolic diseases even many years later. The molecular mechanisms underlying this association are largely unknown, but adipocyte and pancreatic β-cell dysfunction are suspected to be involved. Remarkably, transgenerational damage has been observed, which might be explained by epigenetic changes. Further research is needed to address knowledge gaps and to provide preventive measure to limit health risks connected with exposure to EDCs.

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“…Whereas the main urinary metabolite of DEP is mono-ethyl phthalate (MEP). Remarkably, the bioactivity of phthalate metabolites is superior to that of the original substance [29].…”

Section: Endocrine Disruptors In Dietmentioning

confidence: 99%

Section: Endocrine Disruptors In Dietmentioning

confidence: 99%

Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

et al. 2020

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“…Moreover, emerging evidence suggests that phthalates and BPA can play roles in the development of metabolic pathologies, from obesity to type 2 diabetes [42,43], in particular promoting adipogenesis [44] via peroxisome proliferator-activated receptor gamma [45]. In studies performed on mixtures of different chemicals, a more defined role for MnBP [46], MEP and BPA [47] emerged.…”

Section: Introductionmentioning

confidence: 99%

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Caporossi

Alteri

Campo

et al. 2020

IJERPH

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Among the possible risk factors for male reproduction, exposure to phthalates and alkylphenols is widely documented. This study evaluated the possible association between chemical exposure and the quality of the seminal fluid of 105 subjects in a fertility clinic. The urinary levels of seven phthalate metabolites (monoethylphthalate, MEP; monobenzylphthalate, MBzP; mono n-butylphthalate, MnBP; mono-(2-ethylhexyl) phthalate, MEHP; mono(2-ethyl-5-hydroxyhexyl) phthalate, MEHHP; mono-n-octylphthalate, MnOP; mono-isononylphthalate, MiNP) and bisphenol A (BPA), were analysed by high performance liquid chromatography/tandem mass spectrometry HPLC/MS/MS. The regression analysis showed that the semen volume was positively associated with MnBP, MnOP and BPA levels while was negatively associated with MiNP levels. The sperm concentration had a significant inverse relationship with MEP levels. A negative association was found between the use of plastic containers for food storage (p = 0.037) and semen volume (3.06 vs. 2.30 mL as average values, never vs daily). A significant positive correlation emerged (p < 0.005) between the consumption of canned food and the levels of BPA (2.81 vs. 0.14 µg/g creat as average values, daily vs. never) and between the use of perfumes and levels of MEP (389.86 vs. 48.68 µg/g creat, as average values, daily vs. never). No further statistically significant associations were found, even considering the working activity. Some evidence emerged about the possible link between exposure and seminal fluid quality: further case/control or prospective studies will allow us to confirm this causality hypothesis.

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“…Specifically, it prevents the harmful effects of oxidized low-density lipoprotein, which suggests that it may be involved in inhibiting free radical-mediated cytotoxicity and lipid peroxidation [63,139]. The antioxidant potential of quercetin is approximately four times that of vitamin E [140,141].…”

Section: Quercetin (Flavonoid)mentioning

confidence: 99%

Role of Antioxidants in Alleviating Bisphenol A Toxicity

2020

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Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few decades, studies exploring the mechanism of BPA activity revealed a direct link between BPA-induced oxidative stress and disease pathogenesis. Antioxidants, reducing agents that prevent cellular oxidation reactions, can protect BPA toxicity. Although the important role of antioxidants in minimizing BPA stress has been demonstrated in many studies, a clear consensus on the associated mechanisms is needed, as well as the directives on their efficacy and safety. Herein, considering the distinct biochemical properties of BPA and antioxidants, we provide a framework for understanding how antioxidants alleviate BPA-associated stress. We summarize the current knowledge on the biological function of enzymatic and non-enzymatic antioxidants, and discuss their practical potential as BPA-detoxifying agents.

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The influence of polyphenols on metabolic disorders caused by compounds released from plastics - Review

Cited by 66 publications

References 170 publications

Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center

Role of Antioxidants in Alleviating Bisphenol A Toxicity

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