Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

Filardi, Tiziana; Panimolle, Francesca; Lenzi, Andrea; Morano, Susanna

doi:10.3390/nu12020525

Cited by 82 publications

(44 citation statements)

References 133 publications

(157 reference statements)

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“…It has been considered an endocrine disruptor by the European Chemicals Agency (ECHA 2017) [ 100 ] due to its estrogenic activity. BPA exposure in pregnancy is associated with negative outcomes, including impaired fetal growth and childhood adiposity [ 101 ].…”

Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries. The growing interest in plant-derived substances has led to increased consumption of them also in pregnancy. The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed in various chronic diseases in humans, limited and fragmentary information is currently available about curcumin’s effects on pregnancy and pregnancy-related complications. It is known that immune-metabolic alterations occurring during pregnancy have consequences on both maternal and fetal tissues, leading to short- and long-term complications. The reported anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. The current review summarizes the latest data, mostly obtained from animal models and in vitro studies, on the impact of curcumin on the molecular mechanisms involved in pregnancy pathophysiology, with the aim to shed light on the possible beneficial and/or adverse effects of curcumin on pregnancy outcomes.

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Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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“…Accordingly, a screening approach that takes into account the main GDM risk factors, such as obesity and previous GDM, might anticipate the diagnosis and prevent complications [11][12][13]. In addition, lifestyle, such as diet, physical activity or emerging environmental factors are likely to have an impact on the risk of developing GDM [13][14][15]. The identification of phenotypic classes associated with adverse outcomes, defined by the presence of some risk factors, turned out to be potentially useful in customizing and modulating the diagnostic and therapeutic approach in GDM [16,17].…”

Section: Introduction and Gdm Overviewmentioning

confidence: 99%

Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications

Filardi

Catanzaro

Mardente

et al. 2020

IJMS

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Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the second or third trimester of pregnancy. GDM can lead to short-term and long-term complications both in the mother and in the offspring. Diagnosing and treating this condition is therefore of great importance to avoid poor pregnancy outcomes. There is increasing interest in finding new markers with potential diagnostic, prognostic and therapeutic utility in GDM. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs and circular RNAs, are critically involved in metabolic processes and their dysregulated expression has been reported in several pathological contexts. The aberrant expression of several circulating or placenta-related ncRNAs has been linked to insulin resistance and β-cell dysfunction, the key pathophysiological features of GDM. Furthermore, significant associations between altered ncRNA profiles and GDM-related complications, such as macrosomia or trophoblast dysfunction, have been observed. Remarkably, the deregulation of ncRNAs, which might be linked to a detrimental intrauterine environment, can lead to changes in the expression of target genes in the offspring, possibly contributing to the development of long-term GDM-related complications, such as metabolic and cardiovascular diseases. In this review, all the recent findings on ncRNAs and GDM are summarized, particularly focusing on the molecular aspects and the pathophysiological implications of this complex relationship.

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“…A growing body of evidence has further shown that BPA exposure, even at low doses, may have adverse effects on the outcomes of pregnancy in humans, resulting in potentially harmful conditions for both the mother and the offspring (e.g., affecting the normal development of the foetus and/or causing problems later in life) [ 67 , 68 , 69 , 70 , 71 , 72 , 73 ]. There is also a correlation between BPA exposure and preeclampsia during pregnancy [ 74 , 75 ], which is characterized by newly diagnosed hypertension and proteinuria [ 76 ] and is associated with increased risk of both maternal mortality and health problems for the offspring later in life (e.g., obesity and T2DM) [ 76 , 77 ].…”

Section: Bpa and Comorbidities Predisposing To Severe Covid-19mentioning

confidence: 99%

Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?

Zahra

Sisu

Silva

et al. 2020

JCM

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Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the causative agent of a new disease (COVID-19). The risk of severe COVID-19 is increased by certain underlying comorbidities, including asthma, cancer, cardiovascular disease, hypertension, diabetes, and obesity. Notably, exposure to hormonally active chemicals called endocrine-disrupting chemicals (EDCs) can promote such cardio-metabolic diseases, endocrine-related cancers, and immune system dysregulation and thus, may also be linked to higher risk of severe COVID-19. Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERα and ERβ), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma. As such, this paper focuses on the potential role of BPA in promoting comorbidities associated with severe COVID-19, as well as on potential BPA-induced effects on key SARS-CoV-2 infection mediators, such as angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Interestingly, GPR30 appears to exhibit greater co-localisation with TMPRSS2 in key tissues like lung and prostate, suggesting that BPA exposure may impact on the local expression of these SARS-CoV-2 infection mediators. Overall, the potential role of BPA on the risk and severity of COVID-19 merits further investigation.

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Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

Cited by 82 publications

References 133 publications

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications

Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?

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