The influence of polymorphism of the MUC7 gene on the teeth and dental hygiene of students at a faculty of dentistry in Poland

Buczkowska-Radlińska, Jadwiga; Pol, Justyna; Szmidt, Monika; Bińczak-Kuleta, Agnieszka

doi:10.5604/17322693.991490

Cited by 12 publications

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“…About half of the selected studies analyzed children, 13,14,18,19,20 evaluating primary and permanent dentition, while the other half studied only adults. 12,15,21,22,23,24 Dental caries prevalence was evaluated according to the number of decayed, missing, and filled teeth. There has been no distinction between primary (dmft) and permanent (DMFT) dentition for indexing low and high risk of caries.…”

Section: Resultsmentioning

confidence: 99%

“…Two Polish studies have added to this knowledge by considering the role of their polymorphisms in caries experience, albeit with conflicting results. While Pol 12 has found an association between the MUC7 6/6 genotype and high dental caries experience (p=0.09), in a study with 158 young adults, Buczkowska-Radlinska et al 22 have reported that the distribution of the value of the DMFT index was similar to that of the control group. Vieira et al 10 suggested that these conflicting results might be related to study design issues such as population heterogeneity and statistical power, therefore not yet refuting the results of the original study.…”

Section: Records Identified Through Database Search (N= 424)mentioning

confidence: 97%

“…The study reported on two SNPs (rs2274327 [C/T], rs2274328 [A/C]) in exon 2 of CA VI 15 has found no association between these SNPs and dental caries, salivary pH, or buffering capacity in children and adults. However, Peres et al 22 studied the same SNPs and reported that the variant rs2274327 was associated with a decreased activity of the enzyme in saliva buffer capacity of Brazilian children (p=0.046). Similar results were found later with Brazilian adults, and polymorphism rs2274333 was also associated with decreased CA VI concentration.…”

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confidence: 99%

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Salivary protein polymorphisms and risk of dental caries: a systematic review

et al. 2017

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Dental caries is an oral pathology associated with both lifestyle and genetic factors. The caries process can be influenced by salivary composition, which includes ions and proteins. Studies have described associations between salivary protein polymorphisms and dental caries experience, while others have shown no association with salivary proteins genetic variability. The aim of this study is to assess the influence of salivary protein polymorphisms on the risk of dental caries by means of a systematic review of the current literature. An electronic search was performed in PubMed, Scopus, and Virtual Health Library. The following search terms were used: "dental caries susceptibility," "dental caries," "polymorphism, genetics," "saliva," "proteins," and "peptides." Related MeSH headings and free terms were included. The inclusion criteria comprised clinical investigations of subjects with and without caries. After application of these eligibility criteria, the selected articles were qualified by assessing their methodological quality. Initially, 338 articles were identified from the electronic databases after exclusion of duplicates. Exclusion criteria eliminated 322 articles, and 16 remained for evaluation. Eleven articles found a consistent association between salivary protein polymorphisms and risk of dental caries, for proteins related to antimicrobial activity (beta defensin 1 and lysozyme-like protein), pH control (carbonic anhydrase VI), and bacterial colonization/adhesion (lactotransferrin, mucin, and proline-rich protein Db). This systematic review demonstrated an association between genetic polymorphisms and risk of dental caries for most of the salivary proteins.

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Section: Resultsmentioning

confidence: 99%

Section: Records Identified Through Database Search (N= 424)mentioning

confidence: 97%

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confidence: 99%

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Salivary protein polymorphisms and risk of dental caries: a systematic review

et al. 2017

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“…Mucins and proline-rich proteins take part in bacteria cell agglutination, including cariogenic bacteria [Darshana et al, 2014;Opal et al, 2015]. Researchers examined SNP in genes encoding salivary components -CA6 (for carbonic anhydrase 6), MUC 7 (for mucin), AQP (for aquaporin), and PRH1 (for prolinerich protein 1) [Peres et al, 2010;Yarat et al, 2011;Buczkowska-Radlińska et al, 2012;Koç Öztürk et al, 2012;Wang et al, 2012b;Li et al, 2015;Yildiz et al, 2016]. The relation of the CA6 gene with the buffer capacity of saliva was observed by Yildiz et al [2016] and Peres et al [2010].…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Turska‐Szybka²,

2017

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Recent progress in the field of molecular biology and techniques of DNA sequence analysis allowed determining the meaning of hereditary factors of many common human diseases. Studies of genetic mechanisms in the aetiology of caries encompass, primarily, 4 main groups of genes responsible for (1) the development of enamel, (2) formation and composition of saliva, (3) immunological responses, and (4) carbohydrate metabolism. The aim of this study was to present current knowledge about the influence of single nucleotide polymorphism (SNP) genetic variants on the occurrence of dental caries. PubMed/Medline, Embase, and Cochrane Library databases were searched for papers on the influence of genetic factors connected with SNP on the occurrence of dental caries in children, teenagers, and adults. Thirty original papers written in English were included in this review. Study groups ranged from 30 to 13,000 subjects. SNPs were observed in 30 genes. Results of the majority of studies confirm the participation of hereditary factors in the aetiology of caries. Three genes, AMELX, AQP5, and ESRRB, have the most promising evidence based on multiple replications and data, supporting a role of these genes in caries. The review of the literature proves that SNP is linked with the aetiology of dental caries.

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“…Available studies in the literature have reported a number of the genes related with the following to be associated with lower or higher risk for caries experience: (1) enamel formation: Slayton et al [2005], Deeley et al [2008], Patir et al [2008], Kang et al [2011], Olszowski et al [2012], Shimizu et al [2012], Tannure et al [2012b], Wang et al [2012b], Ergöz et al [2014], Gasse et al [2013] and Jeremias et al [2013]; (2) immune response: Lehner et al [1981], de Vries et al [1985, Bergandi et al [2007], Altun et al [2008], Bagherian et al [2008], Azevedo et al [2010], Ozturk et al [2010], Brancher et al [2011], Pol [2011, Buczkowska-Radlińska et al [2012], Olszowski et al [2012], Valarini et al [2012], Fine et al [2013] and Krasone et al [2014]; (3) saliva: Zakhary et al [2007] and Wang et al [2012b], and (4) other genes: Tannure et al [2012a]. TAS1R2 gene rs35874116, Ile191Val variation has been found to be associated with lower habitual sugar intake [Eny et al, 2010].…”

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confidence: 99%

Association of Sweet Taste Receptor Gene Polymorphisms with Dental Caries Experience in School Children

et al. 2015

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Sweet taste is a powerful factor influencing food acceptance. The peripheral taste response to sugar is mediated by the TAS1R2/TAS1R3 taste receptors. The aim of the study was to determine the relationship between TAS1R2 (rs35874116 or rs9701796) and/or TAS1R3 (rs307355) single nucleotide polymorphisms with dental caries experience in schoolchildren. A total of 184 schoolchildren aged between 7 and 12 years (101 girls, 83 boys) were included in the study. Genomic DNA was extracted from saliva samples and the genotypes were identified by qPCR. The genotype frequencies were as follows: 6.6% for homozygous wild type, 41.8% for heterozygous and 51.6% for homozygous polymorphic genotype carriers of TAS1R2 gene rs35874116; 27.8% for heterozygous and 72.2% for homozygous polymorphic genotype carriers of TAS1R2 gene rs9701796, and 83.1% for homozygous wild type and 16.9% for heterozygous genotype carriers of TAS1R3 gene rs307355 polymorphism. A significant association was observed between total caries experience (dft + DMFT - decayed filled primary teeth + decayed, missing and filled permanent teeth) and TAS1R2 rs35874116 (p = 0.008) and TAS1R3 rs307355 (p = 0.04) gene polymorphisms but not for TAS1R2 gene rs9701796 polymorphism. TAS1R3 gene rs307355 polymorphism has been found to be an independent risk factor for dental caries experience by logistic regression analysis and to have increased the risk of caries. Moderate caries experience (4-7 caries) was found to be associated with TAS1R3 rs307355 heterozygous genotype, whereas high-risk caries experience (>8 caries) was found to be associated with TAS1R2 rs35874116 homozygous polymorphic genotype.

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The influence of polymorphism of the MUC7 gene on the teeth and dental hygiene of students at a faculty of dentistry in Poland

Abstract: This study does not show a correlation between the MUC7 genotypes and caries and oral hygiene of students.

Cited by 12 publications

References 0 publications

Salivary protein polymorphisms and risk of dental caries: a systematic review

Salivary protein polymorphisms and risk of dental caries: a systematic review

Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Association of Sweet Taste Receptor Gene Polymorphisms with Dental Caries Experience in School Children

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