Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Piekoszewska‐Ziętek, Paula; Turska‐Szybka, Anna; Olczak‐Kowalczyk, Dorota

doi:10.1159/000476075

Cited by 736 publications

(30 citation statements)

References 46 publications

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“…Previous studies have demonstrated that genes involved in enamel development are associated with caries susceptibility [Nibali et al, 2017;Piekoszewska-Ziętek et al, 2017] and DDE [Jeremias et al, 2013[Jeremias et al, , 2016. Our study proposes that the polymorphism rs478927 in MMP13 is involved in both conditions.…”

Section: Discussionsupporting

confidence: 51%

MMP13 Contributes to Dental Caries Associated with Developmental Defects of Enamel

et al. 2019

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The aim of this study was to investigate the association between genetic polymorphisms in MMP8, MMP13, and MMP20 with caries experience and developmental defects of enamel (DDE) in children from the Amazon region of Brazil. Den tal caries and DDE data were collected through clinical examination from 216 children. Genomic DNA was extracted from saliva, and genotyping of selected polymorphisms in MMP8 (rs17099443 and rs3765620), MMP13 (rs478927 and rs2252070), and MMP20 (rs1784418) was performed using TaqMan chemistry and endpoint analysis. χ² or Fisher’s exact tests were used to compare allele and genotype distributions between children with caries experience and caries-free children and between DDE-affected and -unaffected children with an established alpha of 5%. The polymorphism rs478927 in MMP13 was associated with caries experience and DDE (p < 0.05). The analysis performed comparing children with both conditions (caries experience plus DDE) and children with neither of the conditions (caries-free chil dren without DDE) demonstrated that children carrying the MMP13 rs478927 TT genotype were more likely to have concomitant occurrence of these two conditions (OR = 5.8, 95% CI 2.1–15.8; p = 0.0003). In conclusion, the genetic polymorphism rs478927 in MMP13 was associated with caries experience and DDE.

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Section: Discussionsupporting

confidence: 51%

MMP13 Contributes to Dental Caries Associated with Developmental Defects of Enamel

et al. 2019

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“…Estimates of the disease variance proportion explained by genetics (often referred to as “heritability”) have ranged from 30% to 70%, with higher estimates found for primary versus permanent dentition caries. Numerous candidate‐gene studies have since been conducted to investigate the postulated role of several hypothesized genes in caries aetiology in children and adults. Studies in this body of literature have largely targeted enamel development and mineralization genes, as well as genes involved in the immune response in early childhood.…”

Section: Introductionmentioning

confidence: 99%

Exploring the genomic basis of early childhood caries: a pilot study

Ballantine

Carlson

Zandoná

et al. 2017

Int J Paed Dentistry

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ObjectiveA genetic component in early childhood caries (ECC) is theorized, but no genome‐wide investigations of ECC have been conducted. This pilot study is part of a long‐term research program aimed to: (1) determine the proportion of ECC variance attributable to the human genome and (2) identify ECC‐associated genetic loci.MethodsThe study's community‐based sample comprised 212 children (mean age=39 months; range = 30–52 months; males = 55%; Hispanic/Latino = 35%, African‐American = 32%; American Academy of Pediatric Dentistry definition of ECC prevalence = 38%). Approximately 2.4 million single nucleotide polymorphisms (SNPs) were genotyped using DNA purified from saliva. A P < 5 × 10−8 criterion was used for genome‐wide significance. SNPs with P < 5 × 10−5 were followed‐up in three independent cohorts of 921 preschool‐age children with similar ECC prevalence.Results SNPs with minor allele frequency ≥5% explained 52% (standard error = 54%) of ECC variance (one‐sided P = 0.03). Unsurprisingly, given the pilot's small sample size, no genome‐wide significant associations were found. An intergenic locus on 4q32 (rs4690994) displayed the strongest association with ECC [P = 2.3 × 10−6; odds ratio (OR) = 3.5; 95% confidence interval (CI) = 2.1–5.9]. Thirteen loci with suggestive associations were followed‐up – none showed evidence of association in the replication samples.ConclusionThis study's findings support a heritable component of ECC and demonstrate the feasibility of conducting genomics studies among preschool‐age children.

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“…Molecular studies have shown a difference in the immunity response of both tasters and non-tasters to different types of cariogenic bacteria (Gil et al, 2015) and others (Farquhar et al, 2015;Verbeurgt et al, 2017). There are a variety of variations in genes associated with a high or low incidence of tooth decay (Piekoszewska-Ziętek et al, 2017); Thus, Dental caries is a multi-factorial disease and cannot be limited to only one factor or gene (Weber, 2016). The current study, although not confirm this relation in this sample, suggests that the presence or compatibility of a number of environmental and genetic factors may shape this association, including a variety of genes, for example, it was found that the heterozygote genotypes of TAS2R38 gene were associated with certain genetic patterns of CA6-encoded carbonic anhydrase 6; an enzyme important in regulating pH capacity of saliva, which in turn affects the degree of tooth consistency and non-erosion when saliva buffer capacity is low (Li et al, 2015;Melis et al, 2018;Esberg et al, 2019) So, the genetic makeup of an individual from many genes and differences in expression of these genes may affect this relation or explain it.…”

Section: Discussionmentioning

confidence: 99%

Dental Caries among Tasters and Non-Tasters of PTC Substance in Students of Qurna Population

Mohaus¹

2019

JMBR

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Objective: Dental caries is one of the most common diseases found in human populations and it is still prevalent and widespread in all around the world. newer strategies emphasize disease prevention as a model of disease management. For early detection and monitoring of caries rather than treatment Taste has valuable roles in our lives in health and disease. genetic markers such as PTC substance taste ability may represent a useful tool to predict the susceptibility to caries. This study aims to investigate the relationship between the taste ability of phenylthiocarbamide (PTC) substance and dental caries. Materials and Methods: The current study was conducted from November 2017 to April 2018 in Qurna and Madiana population/Basrah/Iraq, PTC taste sensitivity was determined among random sample of (406) student from primary and secondary schools; 216 males and 190 females, their ages ranging from (6-17) years old. For dental caries assessment, dmft/DMFT scores were recorded. Individuals were divided into three groups (low, high and very high) according to their dental caries severity in addition to the free caries individuals. Results: The proportion of tasters were higher as compared to non-tasters in this sample. The results showed an increase in the prevalence of caries among primary(68%) and secondary (57.6%) school’s students respectively and for both of them (64.03%). In primary school; females had an elevated percentage of caries (73.1%) compared to their counterpart males (65%). The results of this study did not show a significant relationship between the taste of PTC substance and dental caries, with equal proportions of caries prevalence among tasters and non-tasters (P > 0.05). However, the results showed significant differences in age effect in the prevalence of dental caries among primary and secondary students as it increased in individuals of the age group (6-12) years compared to the age group (13-17) years. Conclusion: The results of this study did not show a significant relationship between the taste of PTC substance and dental caries. In other hand age have a significant influence especially in primary age school and females were more affected than males. The appearance of the two phenotypes of PTC taste may be due to the involvement of other genes, rather than the PTC gene only, including CA6 gene and its variation , which in turn affects the pH capacity of the saliva, a factor associated with tooth decay. Due to the multifactorial nature of dental caries, the individual’s vulnerability may differ from one to another. In addition, particularly regarding diet, part of the strategy to be adopted can be defined as health promotion by preventing the occurrence of the disease rather than treatment. Integrating a healthy dietary regimen into the daily routine can have a real influence on oral health and can be regarded as a primary step towards caries prevention. future research efforts should continue to emphasize early detection and caries prevention strategies.

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Single Nucleotide Polymorphism in the Aetiology of Caries: Systematic Literature Review

Cited by 736 publications

References 46 publications

<b><i>MMP13</i></b> Contributes to Dental Caries Associated with Developmental Defects of Enamel

<b><i>MMP13</i></b> Contributes to Dental Caries Associated with Developmental Defects of Enamel

Exploring the genomic basis of early childhood caries: a pilot study

Dental Caries among Tasters and Non-Tasters of PTC Substance in Students of Qurna Population

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