The influence of pituitary hormones on adjuvant arthritis

Berczi, István; Nagy, Éva; Sylvia, L.; Kovács, Kálmán

doi:10.1002/art.1780270612

Cited by 112 publications

(32 citation statements)

References 36 publications

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“…Several studies suggest that it has immunomodulatory properties. It has been observed that bromocriptine therapy or hypophysectomy can suppress inflammation in the adjuvant arthritis model and that this effect can be overcome with the concurrent administration ofprolactin (5). In addition, pretreatment of mice with bromocriptine for 1 wk will significantly suppress the ability of their lymphocytes to respond in a mixed lymphocyte reaction (6).…”

Section: Introductionmentioning

confidence: 99%

Bromocriptine and low dose cyclosporine in the treatment of experimental autoimmune uveitis in the rat.

Palestine¹,

Muellenberg-Coulombre²,

Kim³

et al. 1987

J. Clin. Invest.

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The immunologic effects of bromocriptine and low dose cyclosporine on experimental autoimmune uveitis (EAU) induced in Lewis rats by S-antigen immunization were studied. Rats treated with a sub-optimal dose (low dose) of cyclosporine (2 mg/kg per d), bromocriptine (1.8 mg/kg per d), or both drugs were compared with untreated rats in regard to the development of EAU, lymphocyte proliferative responses, and anti-S-antigen serum antibodies. Bromocriptine alone decreased the incidence of EAU only in female rats (P < 0.01), did not effect the lymphocyte proliferative response, but did significantly decrease antibody titers in both males (P < 0.004) and females (P < 0.0005). Low dose cyclosporine also partially decreased the incidence of EAU in female rats, but did not decrease antibody titers or lymphocyte proliferative responses. Bromocriptine plus low-dose cyclosporine led to more marked decreases in the incidence of EAU and anti-S-antigen antibody titers as well as in the lymphocyte proliferative assay (P < 0.01 for males, P < 0.0005 for females). This study suggests that bromocriptine can enhance the immunosuppression of low dose cyclosporine.

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Section: Introductionmentioning

confidence: 99%

Bromocriptine and low dose cyclosporine in the treatment of experimental autoimmune uveitis in the rat.

Palestine¹,

Muellenberg-Coulombre²,

Kim³

et al. 1987

J. Clin. Invest.

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“…The central nervous system (CNS) signals to the immune system via hormonal and neural pathways, and the immune system signals to the CNS through various cytokines. The CNS regulates the immune system via pituitary hormones, mainly growth hormone (GH) and prolactin (PRL), which are immunostimulatory (6,7,8,37,44,45,46), and the hypothalamic-pituitaryadrenocortical (HPA) axis, which inhibits immune responses and acts as an immunomodulator-immunosuppressor (16,61,67,68). Whereas most information regarding these interactions is related to systemic immune responses (6,7,16,37,46,61,67,68), much less is known about the interactions between the hypothalamus, the pituitary, and local gastrointestinal immune reactions (9,43,49).…”

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confidence: 99%

Hypophysectomy and Neurointermediate Pituitary Lobectomy Reduce Serum Immunoglobulin M (IgM) and IgG and Intestinal IgA Responses toSalmonella entericaSerovar Typhimurium Infection in Rats

et al. 2006

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The influence of anterior pituitary hormones on the gastrointestinal tract of humans and animals has been reported. Hypophysectomy (HYPOX) in the rat causes atrophy of the intestinal mucosa, reduction of gastric secretion and intestinal absorption, and increased susceptibility to infections. To our knowledge, there are no studies on the humoral immune response of the gut-associated lymphoid tissue after HYPOX. We have reported that decreased secretion of vasopressin and oxytocin due to neurointermediate pituitary lobectomy (NIL) diminishes humoral and cell-mediated immune responses. However, no data have been published on whether NIL can affect intestinal immune responses. We analyzed the effects of HYPOX and NIL on bacterial colonization of the intestinal lumen, Peyer's patches, and spleen as well as the serum immunoglobulin G (IgG) and IgM and specific intestinal IgA levels in response to Salmonella enterica serovar Typhimurium oral infection. Results showed the following: (i) Salmonella serovar Typhimurium was eliminated from the intestinal lumen at the same rate in rats that underwent a sham operation, HYPOX, and NIL; (ii) Salmonella serovar Typhimurium colonization of Peyer's patches and spleen was significantly higher in both HYPOX and NIL rats than in sham-operated rats; (iii) serum IgG and IgM and intestinal IgA against surface proteins of Salmonella serovar Typhimurium were significantly lower in HYPOX and NIL rats than in sham-operated rats; and (iv) compared to NIL rats, higher Peyer's patch and spleen bacterial colonization and decreased IgG, IgM, and IgA production were observed in HYPOX rats. We conclude that hormones from each pituitary lobe affect the systemic and gastrointestinal humoral immune responses through different mechanisms.Multidirectional interactions between nervous, endocrine, and immune systems in health and in the course of inflammatory and infectious diseases have been well established (5). The central nervous system (CNS) signals to the immune system via hormonal and neural pathways, and the immune system signals to the CNS through various cytokines. The CNS regulates the immune system via pituitary hormones, mainly growth hormone (GH) and prolactin (PRL), which are immunostimulatory (6,7,8,37,44,45,46), and the hypothalamic-pituitaryadrenocortical (HPA) axis, which inhibits immune responses and acts as an immunomodulator-immunosuppressor (16,61,67,68). Whereas most information regarding these interactions is related to systemic immune responses (6,7,16,37,46,61,67,68), much less is known about the interactions between the hypothalamus, the pituitary, and local gastrointestinal immune reactions (9,43,49).

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“…It is possible that the ability of T lymphocytes to respond to antigenic stimulation may be modified by prolactin (4). In addition, it has been shown that bromocriptine suppresses inflammation in animals with adjuvantinduced arthritis and that the administration of prolactin reverses this effect (5). Recently, bromocriptine has been used successfully to treat 35 patients with psoriatic arthritis (6).…”

Section: Discussionmentioning

confidence: 99%

Bromocriptine suppresses postpartum exacerbation of collagen‐induced arthritis

Whyte

Williams

1988

Arthritis & Rheumatism

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We administered bromocriptine (Parlodel) to arthritic mice immediately postpartum, and found that the drug suppressed the clinical exacerbation of joint involvement that was seen in untreated animals. Approximately 50% reduction in severity of disease was achieved with bromocriptine (P < 0.001). The effect may be due to suppression of the prolactin release that normally occurs postpartum.Immunization of susceptible strains of mice with heterologous type I1 collagen leads to a disease which causes pathologic changes in the joints that are similar to those that occur in humans with rheumatoid arthritis (1). We have shown that in D B N l mice, there is a remission of this disease during gestation and an exacerbation after parturition (2). Parturition is associated with many hormonal changes, one of the more significant of which is a decrease in the circulating levels of progesterone. The resulting increase in prolactin levels may be involved in the postpartum exacerbation of symptoms of collageninduced arthritis.Bromocriptine, a dopaminergic-receptor stimulant, is prescribed for the control of hyperprolactinemia in cases of hypogonadism and/or galactorrhea, and for the suppression of puerperal lactation. We tested its effect in mice with collagen-induced arthritis after they had given birth. MATERIALS AND METHODSNine-week-old female DBN1 mice (Olac, Bicester, UK) were injected intradermally with 100 pg of bovine type I1 collagen in Freund's complete adjuvant. An intraperitoneal injection of 100 pg of type I1 collagen in 0.1M acetic acid was administered 3 weeks later (2). Syngeneic matings resulted in pregnancies 4-8 weeks after the primary immunizations.At parturition, the mice were randomly assigned to either the treatment group or the control group (12 animals per group). The treatment group was given daily subcutaneous injections of 0.1 mg (approximately 5 mglkg of body weight) of bromocriptine (Parlodel; Sandoz, Middlesex, England) dissolved in ethanokwater (100 pl), 1: 1 volume/volume, over 5 days, commencing on the day the mice gave birth. Mice in the control group received 100 pl of the ethanokwater vehicle only.The severity of arthritis was assessed in individual mice by use of a clinical scoring system (0-4 per limb; maximum score 16) (2). RESULTSThe mean clinical scores in both groups of mice with collagen-induced arthritis are presented in Figure 1. There was an increase in the mean clinical scores in both groups of mice after parturition. However, in the mice given bromocriptine injections, the increased

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The influence of pituitary hormones on adjuvant arthritis

Cited by 112 publications

References 36 publications

Bromocriptine and low dose cyclosporine in the treatment of experimental autoimmune uveitis in the rat.

Bromocriptine and low dose cyclosporine in the treatment of experimental autoimmune uveitis in the rat.

Hypophysectomy and Neurointermediate Pituitary Lobectomy Reduce Serum Immunoglobulin M (IgM) and IgG and Intestinal IgA Responses toSalmonella entericaSerovar Typhimurium Infection in Rats

Bromocriptine suppresses postpartum exacerbation of collagen‐induced arthritis

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