The influence of paracetamol on the erosive activity of indomethacin in the rat stomach

Abstract

Indomethacin induced erosions in the glandular part of the rat stomach in a dose-dependent manner. Gastric erosions became apparent about 15 min after administration of indomethacin and the damage was maximal at about 4 h. The erosive activity of indomethacin administered subcutaneously was similar to that after oral administration, confirming the data of other authors. The erosive activity of subcutaneously applied aspirin, however, was far less than that of oral administered aspirin and it was not dose dependent. In a dose-dependent manner, paracetamol reduced the incidence of gastric erosions induced with indomethacin; this effect was independent of the route of administration of either drug. Paracetamol was also effective when given 0.5 or 1 h before indomethacin. Orally administered paracetamol also reduced the incidence of gastric erosions induced with aspirin but after subcutaneous administration, paracetamol had no protective effect. The differences between the erosive activities of indomethacin and aspirin are discussed with emphasis on the differentiating influence of paracetamol on the incidence of gastric erosions. Direct contact with the mucosa is apparently more important for the erosive activity of aspirin than for that of indomethacin. Possible mechanisms by which paracetamol exerts its protective activity are proposed.

Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L.

“…Aspirin-induced ulcer is mediated through tissue damaging free radicals (Scheiman, 1996), which are produced from the conversion of hydroperoxyl to hydroxy fatty acids, which leads to cell destruction. The hydroperoxyl fatty acids are generated from the degeneration of mast cells and generalized lipid peroxidation accompanying cell damage (Van Kolfschten et al, 1983). In folk medicine, Jasminium grandiflorum leaves have been used for the treatment of ulcerative stomatitis, ulcers, wounds, corns, etc.…”

Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents

“…Aspirin has been reported to convert hydroperoxyl group, generated from generalized lipid peroxidation accompanying cell damage, to hydroxy fatty acids, a reaction that releases damaging free radicals, which ultimately leads to cell death in the gastric tissue. [293031] The MEMS might have scavenged the free radicals produced.…”

Antiulcer Activity of the Most Active Sub-Fraction of Methanolic Leaf Extract of Buchanania Lanzan Spreng

“…An aspirin-induced ulcer is mediated through tissue damaging free radicals, which are produced from the conversion of hydroperoxyl to hydroxy fatty acids, which causes cell destruction. The hydroperoxyl fatty acids are generated from the degeneration of mast cells and generalized lipid peroxidation in addition to cell damage [26]. The present study reveals that F has higher antioxidant activity as compared to other sub-fractions and EA-BLE.…”