The influence of osteoporosis in femoral fracture healing time

Nikolaou, V.S.; Kanakaris, Nikolaos K.; Efstathopoulos, Nicolas; Kontakis, George; Giannoudis, Peter V.

doi:10.1016/j.injury.2009.06.218

Cited by 7 publications

(5 citation statements)

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“…Patients with osteoporosis are characterized by fragility of the bones and they are prone to fractures, representing a common and severe complication that seriously affects patients' quality of life. The increase in bone fragility predisposes to a high rate of implant fixation failure and a less optimal environment for bone formation, leading to prolonged healing time and increased risk of non-union [4]. A previous study confirmed that the osseointegration on the contact surface between an implant and bone tissue is severely inhibited after implantation in osteoporotic animal models [31].…”

Section: Discussionmentioning

confidence: 99%

“…Compared with a healthy skeleton, the osteoporotic bone has two different main characteristics: implant anchorage tends to be deficient [2], and fracture healing takes longer due to a decreased bone mass [3]. A clinical study reported a delayed healing time in femoral fractures of osteoporotic patients when compared to healthy patients [4]. Titanium (Ti) implants are more prone to failure in patients with osteoporotic fractures because of the decreased bone mass and strength, altered microstructure, and reduced regenerative capacity [5], with failure rates as high as 50% reported under osteoporotic condition [6].…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of local bone formation on titanium implants in osteoporotic rats by biomimetic multilayered structures containing parathyroid hormone (PTH)-related protein

et al. 2020

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Osteoporosis is a severe health problem causing bone fragility and consequent fracture. Titanium (Ti) implants, used in patients with osteoporotic fractures, are prone to failure because of the decreased bone mass and strength. Therefore, it is of utmost importance to fabricate implants possessing osteogenic properties to improve implant osseointegration. To improve the long-term survival rate of Ti implants in osteoporotic patients, hyaluronic acid/ϵ-polylysine multilayers containing the parathyroid hormone (PTH)-related protein (PTHrP) were deposited on Ti implants by a layer-by-layer (LBL) electro assembly technique. The murine pre-osteoblast cell line MC3T3-E1, possessing a high potential of osteoblast differentiation, was used to evaluate the osteo-inductive effects of Ti-LBL-PTHrP in vitro. In addition, the performance of the Ti (Ti-LBL-PTHrP) implant was evaluated in vivo in a femoral intramedullary implantation in Sprague Dawley rats. The Ti-LBL-PTHrP implant regulated the release of the loaded PTHrP to increase bone formation in the early stage of implantation. The in vitro results revealed that cells on Ti-LBL-PTHrP did not show any evident proliferation, but a high level of alkaline phosphatase activity and osteoblast-related protein expression was found, compared to the uncoated Ti group (p < 0.05). In addition, in vivo micro-CT and histological analysis demonstrated that the Ti-LBL-PTHrP implants could significantly promote the formation and remodeling of new bone in osteoporotic rats at 14 d after implantation. Overall, this study established a profound and straightforward methodology for the manufacture of biofunctional Ti implants for the treatment of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancement of local bone formation on titanium implants in osteoporotic rats by biomimetic multilayered structures containing parathyroid hormone (PTH)-related protein

et al. 2020

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“…In their place, the new blood vessels and osteoblasts invade. Remodeling: During the lamellar bone formation, osteoblastic laying and osteoclastic removal are happening remodeling the united bone ends [9,10].…”

Section: Introductionmentioning

confidence: 99%

Awareness of Delayed Healing in Post-Operative Fracture Conditions in Osteoporotic Patients

VIJU,

SHAH

2024

Asian J Pharm Clin Res

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Objectives: The study aimed to determine the knowledge of delayed healing in postoperative fracture conditions in osteoporotic patients. Method: In this observational study, 60 subjects were taken between the age group 50–80 years, which consisted of 52% of females and 48% of males. The study was done with self-made questionnaires. Result: A sample of 60 people was taken; out of this, only 11% were aware of the relationship between osteoporosis and fracture healing, and the other 89% lacked the awareness of the relationship between osteoporosis and fracture healing. Conclusion: In this study, it was found that there was 11% of people aware of fracture healing and osteoporosis.

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“…3 Management of osteoporotic bone defect is often hindered by reduced bone healing, subsequent disability, and increased complications. 4,5 Promoting osteoblast activity with the help of biological agents is a feasible approach to prevent the nonunionrelated problems, in addition to improving surgical techniques. 6,7 As the most effective osteoinductive factor, bone morphogenetic protein-2 (BMP-2) has gradually become the focus of laboratory and clinical researches.…”

Section: Introductionmentioning

confidence: 99%

Engineered collagen-binding bone morphogenetic protein-2 incorporated with platelet-rich plasma accelerates lumbar fusion in aged rats with osteopenia

Zhu

Kong

Fang

et al. 2021

Exp Biol Med (Maywood)

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In aged individuals, osteopenia is a great concern for achieving solid spinal fusion. Spinal malunion could lead to various implant-related complications and reduce postoperative quality of life. This study aims to investigate the efficacy of collagen-binding bone morphogenetic protein-2 (CBD-BMP-2) on the treatment of lumbar inter-transverse defects and to explore whether platelet-rich plasma could help CBD-BMP-2 to achieve a better outcome in terms of osteogenesis in senile rats with osteopenia. In vitro experiment proved the angiogenic function of platelet-rich plasma and osteogenic effect of CBD-BMP-2. Rats were performed posterolateral lumbar inter-transverse fusion. Rats implanted with CBD-BMP-2 + platelet-rich plasma were assigned to Group A ( n = 20), rats implanted with CBD-BMP-2 were assigned to Group B ( n = 20), and those with platelet-rich plasma were assigned to Group C ( n = 20). Four weeks after implantation, radiographic assessment, manual palpation, and histological evaluation were performed. In vivo experiments showed satisfactory therapeutic effect on lumbar inter-transverse fusion in both Groups A and B and better results of bone microarchitecture in Group A. Solid fusion rate was 77.8% in Group A, 66.7% in Group B, and 0% in Group C ( P < 0.001). Our study indicated that CBD-BMP-2 could effectively facilitate the lumbar inter-transverse fusion in aged rats with osteopenia and platelet-rich plasma could help CBD-BMP-2 to enhance the bone healing of vertebral defects.

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The influence of osteoporosis in femoral fracture healing time

Cited by 7 publications

References 0 publications

Enhancement of local bone formation on titanium implants in osteoporotic rats by biomimetic multilayered structures containing parathyroid hormone (PTH)-related protein

Enhancement of local bone formation on titanium implants in osteoporotic rats by biomimetic multilayered structures containing parathyroid hormone (PTH)-related protein

Awareness of Delayed Healing in Post-Operative Fracture Conditions in Osteoporotic Patients

Engineered collagen-binding bone morphogenetic protein-2 incorporated with platelet-rich plasma accelerates lumbar fusion in aged rats with osteopenia

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