Enhancement of local bone formation on titanium implants in osteoporotic rats by biomimetic multilayered structures containing parathyroid hormone (PTH)-related protein

Tang, Jiahao; Yan, Daoguang; Chen, Liang; Wang, Bingzhang; Weng, She-Ji; Wu, Zhiping; Xie, Zhongjie; Fang, Kang-Hao; Hong, Chen-Xuan; Xie, Jun; Yang, Lei

doi:10.1088/1748-605x/ab7b3d

Cited by 11 publications

(6 citation statements)

References 54 publications

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“…Jiahao Tang et al deposited a hyaluronic acid/β-polylysine multilayer film containing PTHrP on a titanium implant layer by using layer electro-assembly technology for bone implantation. It was found that the osteoblast cell line MC3T3-E1 showed high levels of ALP activity and osteoblast-related protein expression in vitro ( p < 0.05), and a significant initial increase in osteogenesis was observed in vivo ( Tang et al, 2020 ). Zhou-Shan Tao et al used another electrochemical deposition method to increase the strontium-doped hydroxyapatite coating (PTH + Sr-HA) for an intermittent local administration of the human parathyroid hormone (1–34); micro-CT and biomechanical evaluations were used to assess the improvement of osseointegration and to assist in confirming the feasibility of this method to improve dental osseointegration ( Tao et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Yin²,

Sun³

et al. 2022

Front. Mol. Biosci.

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As clusters of peptides or steroids capable of high-efficiency information transmission, hormones have been substantiated to coordinate metabolism, growth, development, and other physiological processes, especially in bone physiology and repair metabolism. In recent years, the application of hormones for implant osseointegration has become a research hotspot. Herein, we provide a comprehensive overview of the relevant reports on endogenous hormones and their corresponding supplementary preparations to explore the association between hormones and the prognosis of implants. We also discuss the effects and mechanisms of insulin, parathyroid hormone, melatonin, vitamin D, and growth hormone on osseointegration at the molecular and body levels to provide a foothold and guide future research on the systemic conditions that affect the implantation process and expand the relative contraindications of the implant, and the pre-and post-operative precautions. This review shows that systemic hormones can regulate the osseointegration of oral implants through endogenous or exogenous drug-delivery methods.

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Section: Introductionmentioning

confidence: 99%

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Yin²,

Sun³

et al. 2022

Front. Mol. Biosci.

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“…[46][47][48][49][50][51][52] Since bone remodeling and osteoconductive properties are essential for osteointegration into the pores of a biomaterial, surface derivatization using various biological agents and inorganic elements can additionally enhance the process by creating an osteoconductive milieu. These include anti-osteoporosis drugs such as Strontium ranelate and simvastatin, [53][54][55][56][57] bioactive molecules such as bone morphogenetic protein (BMP) and vascular endothelial growth factor (VEGF), 48,[58][59][60] and bioactive inorganic elements such as calcium (Ca), strontium (Sr), magnesium (Mg), zinc (Zn), and silicon (Si). [61][62][63] Mechano-transduction is a critical determinant of new bone formation, repair and regeneration, and adaptation of bone to its external environment.…”

Section: Discussionmentioning

confidence: 99%

A porous swelling copolymeric material for improved implant fixation to bone

et al. 2023

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Most metallic commercial bone anchors, such as screws and suture anchors achieve their fixation to bone through shear of the bone located between the threads. They have several deficiencies, potentially leading to failure, which are particularly evident in low‐density bone. These include stress‐shielding resulting from mechanical properties mismatch; lack of mechanically induced remodeling and osteointegration; and when the pullout force on the anchor, during functional activities, exceeds their pullout strength, catastrophic failure occurs leaving behind large bone defects that may be hard to repair. To overcome these deficiencies, we introduced in this study a porous swelling co‐polymeric material and studied its swelling and compressive mechanical characteristics as bone anchor under different configurations. Porosity was achieved by adding a non‐dissolvable agent (NaCl) during the process of polymerization, which was later dissolved in water, leaving behind a porous structure with adequate porosity for osteointegration. Three different groups of cylindrical samples of the swelling co‐polymer were investigated. Solid, fully porous, and partially porous with a solid core and a porous outer layer. The results of the swelling and simple compression study show that the partially porous swelling co‐polymer maintains excellent mechanical properties matching those of cancellous bone, quick swelling response, and an adequate porous outer layer for mechanically induced osteointegration. These suggest that this material may present an effective alternative to conventional bone anchors particularly in low‐density bone.

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“…And the gel could enhance the release and uptake ratio of bone morphogenetic protein 4 and inhibit corneal neovascularization after eye injury (Xu et al, 2020). Also, the compounds composed of EPL combined with hyaluronic acid and parathyroid hormone-related protein could be used in forming multilayers as modification to titanium implants used in osteoporosis treatment, and enhance the local bone formation (Tang et al, 2020). They could also be synthesized as lipase-(ε-polylysine-heparin)-glassy carbon electrode to help detect triglycerides, one of the main biomarkers of cardiovascular diseases (Xu et al, 2018).…”

Section: Other Drugs Delivery Systemmentioning

confidence: 99%

Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

Chen

Huang

et al. 2021

Front. Chem.

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With the advantages in biocompatibility, antimicrobial ability, and comparative facile synthesis technology, poly-L-lysine (PLL) has received considerable attention in recent years. Different arrangement forms and structures of the backbone endow lysine-based polymers with versatile applications, especially for ε-poly-L-lysine (EPL) and lysine-based dendrimer (LBD) compounds. This review summarized the advanced development of the synthesis and modification strategies of EPL and LBD, focus on the modification of bio-synthesis and artificial synthesis, respectively. Meanwhile, biomedical fields, where EPL and LBD are mainly utilized, such as agents, adjuvants, or carriers to anti-pathogen or used in tumor or gene therapies, are also introduced. With the deeper of knowledge of pharmacodynamics and pharmacokinetics of the drug system, the design and synthesis of these drugs can be further optimized. Furthermore, the performances of combination with other advanced methodologies and technologies demonstrated that challenges, such as scale production and high expenses, will not hinder the prospective future of lysine-based polymers.

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Enhancement of local bone formation on titanium implants in osteoporotic rats by biomimetic multilayered structures containing parathyroid hormone (PTH)-related protein

Cited by 11 publications

References 54 publications

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

Hormone and implant osseointegration: Elaboration of the relationship among function, preclinical, and clinical practice

A porous swelling copolymeric material for improved implant fixation to bone

Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications

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