The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study

Xu, Xinran; Gammon, Marilie D.; Jefferson, Elizabeth; Zhang, Yujing; Cho, Yoon Hee; Wetmur, James G.; Teitelbaum, Susan L.; Bradshaw, Patrick T.; Terry, Mary Beth; Garbowski, Gail; Hibshoosh, Hanina; Neugut, Alfred I.; Santella, Regina M.; Chen, Jia

doi:10.4161/epi.6.11.17744

Cited by 17 publications

(46 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been well-established in the field of epigenetics that aberrant DNA methylation, together with numerous genetic alterations, is a hallmark of cancer [8]. The event may lead to altered transcription of salient regulatory genes that could lead to malignant cellular transformation [9].…”

Section: Introductionmentioning

confidence: 99%

“…The downregulation of RARB, BRCA1, and RASSF1A genes has been frequently considered in breast carcinogenesis and has recently been implicated in the prognosis of neoadjuvant therapy [4,6,11]. More importantly, evidence suggests that their promoter includes accountable CpG-rich regions at cis-regulatory sequences that are frequently observed to undergo aberrant hypermethylation in favor of breast tumorogenesis [3,7,8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients

et al. 2015

View full text Add to dashboard Cite

Hypermethylation at promoters of RARB, BRCA1, and RASSF1A is associated with reduced transcript levels of the respective gene in primary breast cancer tissue samples. Dietary folate and cobalamin intake is inversely associated with methylated RARB and BRCA1. High dietary intake of riboflavin and pyridoxine is associated with increased methylation in the RARB promoter. There is evidence for the age-dependent effects of nutrient intake on promoter methylation status. Bioavailability to the pool of nutrients might determine selectivity.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In contrast, another study reported a significant decrease in CpG promoter DNA methylation of E -cadherin was associated with higher levels of dietary vitamin B 6 and vitamin B 12 intakes, and a signifi cant decrease in CpG promoter DNA methylation of CCDN2 ( cyclin D2 ) was associated with higher levels of dietary folate and vitamin B 6 intakes (Xu et al 2011 ). Finally, higher levels of dietary betaine and vitamin B 6 intakes were signifi cantly associated with an increase in CpG promoter DNA methylation of APC and HIN1 , respectively (Xu et al 2011 ). Based on these fi ndings, three genes found to be most sensitive to dietary intakes of one-carbon nutrients were cyclin D2 , HIN1 , and E -cadherin , genes with tumor suppressing and oncogenic properties, and vitamin B 6 possessed the greatest potential among all the one-carbon nutrients investigated to modulate CpG promoter DNA methylation (Xu et al 2011 ).…”

Section: Breast Cancermentioning

confidence: 73%

“…Similarly, another study found that CpG promoter DNA methylation of CDH1 ( E -cadherin ), p16 , and RAR -β 2 genes in breast tumor tissue was not modulated by dietary intakes of folate and vitamins B 6 and B 12 (Tao et al 2011 ). In contrast, another study reported a significant decrease in CpG promoter DNA methylation of E -cadherin was associated with higher levels of dietary vitamin B 6 and vitamin B 12 intakes, and a signifi cant decrease in CpG promoter DNA methylation of CCDN2 ( cyclin D2 ) was associated with higher levels of dietary folate and vitamin B 6 intakes (Xu et al 2011 ). Finally, higher levels of dietary betaine and vitamin B 6 intakes were signifi cantly associated with an increase in CpG promoter DNA methylation of APC and HIN1 , respectively (Xu et al 2011 ).…”

Section: Breast Cancermentioning

confidence: 82%

“…Finally, higher levels of dietary betaine and vitamin B 6 intakes were signifi cantly associated with an increase in CpG promoter DNA methylation of APC and HIN1 , respectively (Xu et al 2011 ). Based on these fi ndings, three genes found to be most sensitive to dietary intakes of one-carbon nutrients were cyclin D2 , HIN1 , and E -cadherin , genes with tumor suppressing and oncogenic properties, and vitamin B 6 possessed the greatest potential among all the one-carbon nutrients investigated to modulate CpG promoter DNA methylation (Xu et al 2011 ). Overall, these results provide preliminary evidence that one-carbon nutrients may modulate breast cancer risk by potentially altering the expression of genes implicated in breast carcinogenesis via changes in gene-specifi c CpG promoter DNA methylation.…”

Section: Breast Cancermentioning

confidence: 99%

See 1 more Smart Citation

One-Carbon Metabolism Nutrients and Epigenetics: A Mechanistic Link Between Aberrant One-Carbon Metabolism and Cancer Risk?

Masih

Plumptre

Kim

2014

Molecular Mechanisms and Physiology of Disease

View full text Add to dashboard Cite

In relation to the genome, investigation of the epigenome is emerging as an equal, if not more infl uential factor in modulating human health and disease. Since epigenetic modifi cations are gradual in onset and potentially reversible, determining factors that modulate the epigenome is critical for possible preventive and therapeutic interventions. The development and progression of cancer is mechanistically linked to a number of epigenetic changes, including global DNA hypomethylation and genespecifi c CpG promoter DNA hypermethylation. Environmental factors, including diet, have been shown to affect cancer risk, via epigenetic and non-epigenetic mechanisms. In this regard, one-carbon nutrients are prototypic dietary factors that may modulate cancer risk via epigenetic mechanisms. This chapter will discuss the role of nutrients involved in one-carbon metabolism and their effect on cancer risk via epigenetic modifi cations with a particular focus on DNA methylation.

show abstract

Urinary parabens and breast cancer risk: Modification by LINE‐1 and LUMA global DNA methylation, and associations with breast cancer defined by tumor promoter methylation status

Parada

Sahrai

Wolff

et al. 2022

Molecular Carcinogenesis

Self Cite

View full text Add to dashboard Cite

Parabens are a group of alkyl esters of p-hydroxybenzoic acid added to consumer products to prevent the growth of harmful bacteria and molds. Parabens are hypothesized to increase the risk of breast cancer (BC); however, no study has examined the interactions between parabens, global DNA methylation (DNAm), and BC risk. We examined the modifying effects of DNAm on the associations between parabens and BC, and whether parabens were associated with BC defined by tumor promoter methylation status. Participants included 708 cases and 598 controls from the Long Island Breast Cancer Study Project. Methylparaben (MPB), propylparaben, and butylparaben levels were measured in spot urine samples. Global DNAm was measured by analysis of long interspersed elementes-1 (LINE-1) and the luminometric methylation assay (LUMA). The promoter methylation status of 13 genes was measured in tumor samples from 509 cases. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between parabens and BC stratified by LINE-1/LUMA, and between parabens and genespecific promoter methylation-defined BC. Outcome heterogeneity was evaluated using ratios of ORs (RORs). We assessed the joint effects of the multiple parabens using quantile g-computation. The highest versus lowest tertile of MPB and a one-quantile increase in all parabens were associated with ORs of 1.46 (95% CI = 0.96-2.23) and 1.32 (95% CI = 1.02-1.71), respectively, among women with hypomethylated LINE-1. A one-ln unit increase in MPB was associated with a 25% increase in the odds of hypomethylated (vs. hypermethylated) CCND2 promoter-defined BC (ROR = 1.25, 95% CI = 1.06-1.48), and a one-quantile increase in all parabens was associated with a 55% increase in the odds of hypomethylated (vs. hypermethylated) CCND2 promoter-defined BC (ROR = 1.55, 95% CI = 1.04-2.32). Exposure to parabens may increase the risk of BC among

show abstract

The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study

Cited by 17 publications

References 43 publications

Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients

Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients

One-Carbon Metabolism Nutrients and Epigenetics: A Mechanistic Link Between Aberrant One-Carbon Metabolism and Cancer Risk?

Urinary parabens and breast cancer risk: Modification by LINE‐1 and LUMA global DNA methylation, and associations with breast cancer defined by tumor promoter methylation status

Contact Info

Product

Resources

About