Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients

Pirouzpanah, Saeed; Taleban, Forough-Azam; Mehdipour, Parvin; Atri, Morteza

doi:10.1007/s00109-015-1268-0

Cited by 43 publications

(36 citation statements)

References 37 publications

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“…The T version of the MTHFR C677T polymorphism results in the substitution of an alanine residue with a valine, leading to a 50% reduction in enzymatic activity, and 10–20% of individuals in Western Europe and North America have the 677TT genotype . Observational studies have reported that higher levels of folic acid and vitamin B 12 in the diet are associated with higher global DNA methylation levels . However, contrary to our findings, Jung et al .…”

Section: Discussioncontrasting

confidence: 99%

“…Nutrients and other food components can modify DNA methylation patterns to modulate biological functions that influence health and aging. Higher intakes or status of several micronutrients participate in one‐carbon metabolism, including folate, choline, betaine, methionine, vitamin B 6 , and vitamin B 12 , which contribute to SAM production are associated with increased DNA methylation . Other nutrients, including flavanols and (–)‐epigallocatechin‐3‐gallate (EGCG), are competitive inhibitors of DNMTs through binding within the active site of the enzyme, leading to decreased global DNA methylation.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock

Sae-Lee

Corsi

Barrow

et al. 2018

Molecular Nutrition Food Res

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Scope Alterations in DNA methylation patterns are correlated with aging, environmental exposures, and disease pathophysiology; the possibility of reverting or preventing these processes through dietary intervention is gaining momentum. In particular, methyl donors that provide S‐adenosyl‐methionine for one‐carbon metabolism and polyphenols such as flavanols that inhibit the activity of DNA methyltransferases (DNMTs) can be key modifiers of epigenetic patterns. Methods and results DNA methylation patterns are assessed in publicly available Illumina Infinium 450K methylation datasets from intervention studies with either folic acid + vitamin B12 (GSE74548) or monomeric and oligomeric flavanols (MOF) (GSE54690) in 44 and 13 participants, respectively. Global DNA methylation levels are increased in unmethylated regions such as CpG islands and shores following folic acid + vitamin B12 supplementation and decreased in highly methylated regions, including shelves and open‐seas, following intervention with MOF. After supplementation with folic acid + vitamin B12, epigenetic age, estimated by the Horvath “epigenetic clock” model, is reduced in women with the MTHFR 677CC genotype. Conclusions The effects of supplementation with folic acid + vitamin B12 and MOF on DNA methylation age are dependent upon gender and MTHFR genotype. Additionally, the findings demonstrate the potential for these dietary factors to modulate global DNA methylation profiles.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock

Sae-Lee

Corsi

Barrow

et al. 2018

Molecular Nutrition Food Res

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“…Vitamin C exhibits antioxidant actions including the neutralisation of free radicals, which may impact cancer progression 26,27 . Furthermore, dietary intake of folate was associated with a reduced death by inducing incorporation of uracil into DNA and inducing altered gene expression of critical tumor suppressor and proto-oncogenes via its role in DNA methylation 28–30 . Epidemiological studies 31 and clinical trial 32 have suggested that a high fiber intake was related to reductions in blood levels of estrogen.…”

Section: Discussionmentioning

confidence: 99%

“…Only full-length original articles published in English were considered, and no attempt was made to include abstracts or unpublished data. This meta-analysis was planned, conducted, and reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement 28 .…”

Section: Methodsmentioning

confidence: 99%

Consumption of vegetables and fruits and breast cancer survival: a systematic review and meta-analysis

Zhang

2017

Sci Rep

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We aimed to conduct a meta-analysis investigating the association between consumption of vegetables and fruits and breast cancer survival. A comprehensive search of the PubMed and EMBASE was performed from the inception to September 30, 2016. The summary hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a random effects model. Ten studies, with a total of 31,210 breast cancer cases, were included in the meta-analysis. The summary HRs (95% CIs) of overall survival (highest vs. lowest) were 1.08 (0.88–1.33; I2 = 41.1%) for pre-diagnostic intake of vegetables and fruits combined, 0.96 (0.71–1.30; I2 = 48.4%) for vegetables alone, and 0.83 (0.67–1.02; I2 = 0) for fruit alone. No significant risk associations of overall survival were found for post-diagnostic intake of vegetables and fruits. Line dose-response analyses indicated the likely results for both pre- and post- diagnostic dietary intake. No significant association was found between intake of vegetables and fruits and breast cancer-specific mortality. In addition, intake of cruciferous vegetables was not associated with death from breast cancer. Our findings indicated a borderline inverse association between pre-diagnostic intake of fruit and overall survival of breast cancer, whereas intake of vegetables was not associated with survival.

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“…Due to the considerably increased incidence rate of breast cancer, it could be considered as one of the most common health problems across different populations [3,4]. In developing countries including Iran, patients diagnosed with breast cancer are 10 years younger compared to those in developed countries [3].…”

Section: Introductionmentioning

confidence: 99%

Promoter Methylation Status of the Retinoic Acid Receptor-Beta 2 Gene in Breast Cancer Patients: A Case Control Study and Systematic Review

Yari¹,

Rahimi

2019

Breast Care

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Background: We aimed to determine the promoter methylation status of the retinoic acid receptor-beta 2 (RARβ2) gene among breast cancer patients and to review relevant studies in this field in various populations. Methods: We analyzed 400 samples which comprised blood specimens from 102 breast cancer patients, 102 first-degree female relatives of patients, 100 cancer-free females, 48 breast cancer tissues, and 48 adjacent normal breast tissues from the same patients. The RARβ2 methylation status was determined using methylation-specific polymerase chain reaction (MSP) and DNA sequencing methods. Results: The presence of combined partially methylated (MU) and fully methylated (MM) forms of the RARβ2 gene (MU+MM) in the blood of patients was associated with susceptibility to breast cancer (odds ratio = 4.7, p = 0.05). A significantly higher frequency of the MM genotype was observed in cancer tissue (10.4%) compared to matched adjacent normal breast tissue (0%) (p = 0.02). Conclusion: We found a higher frequency of RARβ2 gene methylation in the blood and cancer tissues of patients compared to the blood of controls and adjacent normal breast tissues. The survey of studies on various populations demonstrated a higher RARβ2 methylation frequency in breast cancer patients compared to normal individuals, and many reports suggest a significant association between hypermethylation of the gene and susceptibility to breast cancer.

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Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients

Cited by 43 publications

References 37 publications

Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock

Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock

Consumption of vegetables and fruits and breast cancer survival: a systematic review and meta-analysis

Promoter Methylation Status of the Retinoic Acid Receptor-Beta 2 Gene in Breast Cancer Patients: A Case Control Study and Systematic Review

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