The Influence of Noopept on Morphological, Electrophysiological, and Biochemical Changes in the Retina during the Experimental Thrombosis of Its Vessels

Kolesnikov, Alexander V.; Shchulkin, A. V.; Pisklova, M. V.; Barenina, O. I.; Yakusheva, E. N.; Кудрин, В. С.; Ostrovskaya, R. U.; Узбеков, М. Г.; Shishkin, М.М.

doi:10.1134/s181971241801004x

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“…The concentration of monoamines (nmol/g of tissue) in the experimental samples was calculated by the internal standard method, based on the ratio of the peak areas in the standard mixture and in the experimental sample. The content of neurotransmitter amino acids was determined by HPLC/ED according to the standard method [3,5]. A mixture of aspartate, glutamate, taurine and GABA at a concentration of 0.1 μM in 0.1 N. HClO 4 was used as a standard solution for calibrating the sorbent column.…”

Section: Methodsmentioning

confidence: 99%

Antibodies to Glutamate Facilitate Spatial Memory Formation in the Morris Water Maze in Aging C57BL/6 mice

et al. 2020

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Intranasal administration of antibodies to glutamate at dose of 250 μg/kg for two weeks facilitated spatial learning and memory formation in the Morris water maze in aging C57Bl/6 mice. Concurrently, in the animals treated with glutamate antibodies, there was a decrease in serotonin level, no change in dopamine but a reduction in 3-MT and HVA metabolite concentrations in the hippocampus. In the prefrontal cortex, a decrease in dopamine level occurred along with a simultaneous increase in the content of its metabolite, DOPAC, as well as an increase in excitatory and inhibitory amino acid neurotransmitters: aspartic acid, glutamate, glycine, taurine and GABA. It was concluded that Abs-Glu facilitated spatial learning and memory formation through a remodeling of the hippocampal and prefrontal cortical neurochemical system in aging C57Bl/6 mice.

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Section: Methodsmentioning

confidence: 99%