The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis

Barboza-Filho, Carlos Gomes; Cabrera, Flávio Camargo; Santos, Renivaldo José dos; Sáez, José A.; Job, Aldo Eloízo

doi:10.1016/j.exppara.2011.10.015

Cited by 36 publications

(17 citation statements)

References 39 publications

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“…It is worth mentioning that the population decrease noted in fall phase is intensified with increasing nanoparticles concentration in the nanocomposite, indicating that probably the same reason that is causing changes in culture proteins, facilitating their ingestion, is also hindering the absorption of these proteins by the parasites, accelerating nutritional starvation. Comparing the morphological characteristics of the parasites exposed to NR/KSN-5phr nanocomposites with colony control parasites [43,44], one could clearly identify the kinetoplast and nucleus cell, but no significant morphological differences were observed, confirming the similarity of the curves in Figure 13 (a).…”

Section: Biological Study: Toxicity Evaluationsupporting

confidence: 54%

“…Comparing the morphological characteristics of the parasites exposed to NR/NZF-5phr nanocomposites with colony control parasites [43,44], there is a clear morphological difference in cell design. Control parasites has elongated cell bodies, while for parasites in contact with NR/NZF-5phr, the cell body has approximately a circular shape.…”

Section: Biological Study: Toxicity Evaluationmentioning

confidence: 99%

See 1 more Smart Citation

Utilization of Composites and Nanocomposites Based on Natural Rubber and Ceramic Nanoparticles as Control Agents for Leishmania braziliensis

Job¹,

Siqueira²,

Danna³

et al. 2014

Leishmaniasis - Trends in Epidemiology, Diagnosis and Treatment

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Please use Adobe Acrobat Reader to read this book chapter for free. Just open this same document with Adobe Reader. If you do not have it, you can download it here. You can freely access the chapter at the Web Viewer here. differentiated properties can be transferred to other materials by the insertion of the nanomaterials in a matrix of a different nature and nanometric scale not generating a nanocomposite material[1, 2]. In general, the choice of polymer as a matrix or continuous phase is preferable since most have appreciable thermal and mechanical properties. Other properties must also be taken into account, such as hydrophobic/hydrophilic balance, chemical stability and biocompatibility. The nanometric component, generally inorganic, known as the dispersed phase, can provide a higher mechanical, thermal stability and also biological properties [3]. Multidisciplinary researches involving nanoscience, nanotechnology, materials science and engineering, biotechnology and health sciences have gained great strength in recent decades, aiming to increase the number of tools for addressing problems [4]. Each day new materials and methodologies are tested in fighting diseases such as cancer and diseases neglected by the pharmaceutical industry, for example, malaria, leishmaniasis and Chagas' disease. As a result of this innovation, nanocomposites and composites based in natural rubber filled with ceramic particle and nanoparticles can be used in biological applications, aiming at development of devices such as intelligent bandages or agents of control and reduction of parasitic colonies [5]. 1.2. Leishmania braziliensis Leishmaniasis is a endemic and parasitic infection caused by the Leishmania genus protozoa. Approximately 1.5 million people were affected by cutaneous leishmaniasis, which reaches 88 countries and has compulsory notification in only 30 of them. Presents itself throughout the Americas and Brazil is the country that has the highest prevalence of cases. Leishmaniasis is a typically tropical disease from Trypanosomatidae family, affecting the skin (cutaneous leishmaniasis, caused by Leishmania braziliensis protozoans) or viscera (visceral leishmaniasis, caused by Leishmania donovani protozoans), transmitted by the bite of the vector, a phlebotomine sand fly popularly known as "straw mosquito", which utilizes both animals and humans as host [6, 7]. Protozoans of Leishmania genus are unicellular, eukaryotic, heterotrophic, with asexual reproduction by binary fission, and feed via uptake of non-self-generated food. Within the human body, Leishmania protozoans feed of proteins present intracellularly or in blood plasma, and reproduce only within macrophages or similar cells of the immune system[6, 7]. 1.3. Ceramic materials Ceramic materials (in general, oxides, carbides or nitrides) are inorganic, non-metallic substances consisting of metallic and non-metallic elements connected together by covalent and/or ionic bonds. This class of materials displays a set of distinguished physical and chemical properties s...

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Section: Biological Study: Toxicity Evaluationsupporting

confidence: 54%

Section: Biological Study: Toxicity Evaluationmentioning

confidence: 99%

Utilization of Composites and Nanocomposites Based on Natural Rubber and Ceramic Nanoparticles as Control Agents for Leishmania braziliensis

Job¹,

Siqueira²,

Danna³

et al. 2014

Leishmaniasis - Trends in Epidemiology, Diagnosis and Treatment

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show abstract

“…The mass loss in the temperature range 300-450°C (the most intense peak shown in Fig. 3b) is due to the structural decomposition of NR chains and corresponds to approximately 88, 74, 56, and 41% for the NR, 90/10, 70/30, and 50/50 samples, respectively [38,39]. For the NR, the maximum rate of mass loss occurs at 365°C, as exhibited by the most intense peak in Fig.…”

Section: Thermal Analysesmentioning

confidence: 92%

Study of thermal and mechanical properties of a biocomposite based on natural rubber and 45S5 Bioglass® particles

Silva

Soares

Dias

et al. 2016

J Therm Anal Calorim

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Biocomposites based on natural rubber (NR) reinforced with 45S5 BioglassÒ (BG) particles were obtained by casting/evaporation method in which NR was dissolved in chloroform and mixed with BG particles. Structural, mechanical, and thermal tests were performed on the biocomposites to evaluate the influence of BG particles on the properties of the NR matrix. Thermogravimetric tests (TG/DTG) of the biocomposites showed decomposition profiles similar to that of NR, and the main peak of the DTG curve was well defined in the temperature range 300-450°C, characteristic of the structural degradation of NR. The TG analysis also revealed that the thermal stability of the samples increases with the increasing quantity of BG in the biocomposite. DMA tests showed higher storage modulus (E 0) values for samples with larger amounts of BG; however, above the T g , the E 0 value tended to zero due to the increased mobility of the polymer chains. By analyzing tan d, the T g values were calculated to be-46 and-50°C for NR and the biocomposite samples, respectively. Mechanical testing demonstrated that the addition of BG to the biocomposite improved the mechanical properties of the samples. The samples became more rigid with the increasing quantity of BG, as demonstrated by decreasing deformation and the increasing elastic modulus (Y) and breaking strength of the samples. The BG particles positively affected the mechanical and thermal properties of the biocomposite, allowing its use in biomedical applications.

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“…More recently, Barboza-Filho et al [52] studied the growth of Leishmania brasiliensis promastigotes in culture, using natural rubber membranes with and without gold nanoparticles. It was observed that the increase of AuNP caused a decrease in the number of promastigotes in culture medium.…”

Section: Nanogold Chemotherapy and Thermotherapymentioning

confidence: 99%

The role of nanogold in human tropical diseases: research, detection and therapy

Almeida

Carabineiro

2013

Gold Bull

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The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis

Cited by 36 publications

References 39 publications

Utilization of Composites and Nanocomposites Based on Natural Rubber and Ceramic Nanoparticles as Control Agents for Leishmania braziliensis

Utilization of Composites and Nanocomposites Based on Natural Rubber and Ceramic Nanoparticles as Control Agents for Leishmania braziliensis

Study of thermal and mechanical properties of a biocomposite based on natural rubber and 45S5 Bioglass® particles

The role of nanogold in human tropical diseases: research, detection and therapy

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