The role of nanogold in human tropical diseases: research, detection and therapy

Almeida, Miguel Peixoto de; Carabineiro, Sónia A.C.

doi:10.1007/s13404-013-0086-9

Cited by 5 publications

(3 citation statements)

References 82 publications

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“…It is important to note that we have limited further discussion of AuNPs since their use in diagnostics and sensing applications has been extensively reviewed. 177,219,222−226 Given the vast literature that exists for AuNP applications, we have elected to focus on the applications of AgNPs as signal generation probes for infectious disease diagnosis. Similar to AuNPs, localized SPR of AgNPs has been capitalized upon to develop colorimetric assays for infectious disease protein and nucleic acid biomarkers.…”

Section: Metal-based Signal Generationmentioning

confidence: 99%

“…It is important to note that we have limited further discussion of AuNPs since their use in diagnostics and sensing applications has been extensively reviewed. ,,− Given the vast literature that exists for AuNP applications, we have elected to focus on the applications of AgNPs as signal generation probes for infectious disease diagnosis. Similar to AuNPs, localized SPR of AgNPs has been capitalized upon to develop colorimetric assays for infectious disease protein and nucleic acid biomarkers. − Additionally, the conjugation of fluorescent probes (e.g., FAM) to AgNP surfaces, as well as the intrinsic luminescence of some AgNPs, has permitted the development of luminescence-based assays. , The high AgNP conductivity has also been exploited for electrochemical detection of nucleic acids. − Lastly, surface-enhanced Raman spectroscopy (SERS) of AgNPs has been employed for the direct detection of malaria-infected red blood cells because of the significant light scattering of AgNPs and the high specificity of Raman signatures. ,− …”

Section: Metal-based Signal Generationmentioning

confidence: 99%

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Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics

et al. 2018

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Infectious diseases claim millions of lives each year. Robust and accurate diagnostics are essential tools for identifying those who are at risk and in need of treatment in low-resource settings. Inorganic complexes and metal-based nanomaterials continue to drive the development of diagnostic platforms and strategies that enable infectious disease detection in low-resource settings. In this review, we highlight works from the past 20 years in which inorganic chemistry and nanotechnology were implemented in each of the core components that make up a diagnostic test. First, we present how inorganic biomarkers and their properties are leveraged for infectious disease detection. In the following section, we detail metal-based technologies that have been employed for sample preparation and biomarker isolation from sample matrices. We then describe how inorganic- and nanomaterial-based probes have been utilized in point-of-care diagnostics for signal generation. The following section discusses instrumentation for signal readout in resource-limited settings. Next, we highlight the detection of nucleic acids at the point of care as an emerging application of inorganic chemistry. Lastly, we consider the challenges that remain for translation of the aforementioned diagnostic platforms to low-resource settings.

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Section: Metal-based Signal Generationmentioning

confidence: 99%

Section: Metal-based Signal Generationmentioning

confidence: 99%

Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics

et al. 2018

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“…7 Research on the use of gold for the treatment of human tropical diseases is therefore now considerable, 8 but studies have also focused on using AuNPs in the context of diagnosis and drug delivery. 2,9,10 For example, employing AuNPs in polymerase chain reaction (PCR) has optimized the specificity of this diagnostic method.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and hepatoprotective role of gold nanoparticles against murine hepatic schistosomiasis

Dkhil¹,

Bauomy²,

Diab³

et al. 2015

IJN

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In recent years, gold nanoparticles (AuNPs) have become the focus of much attention in biomedical research, especially in the context of nanomedicine, due to their distinctive physicochemical properties. The current study was planned to assess the effect of three dose levels of AuNPs on the gene expression, histology, and oxidative stress status of Schistosoma mansoni -infected mice liver. Inoculation of mice with 100 μL AuNPs at different doses (0.25, 0.5, and 1 mg/kg mice body weight) twice on day 46 and day 49 postinfection reduced the total worm burden, the egg load in the liver, and the granuloma size. AuNPs also appeared to decrease the activities of malondialdehyde and nitric oxide significantly, and increase the level of glutathione compared to the infected untreated group. Concomitantly, AuNPs ameliorated the inflammatory response by decreasing the mRNA expression of interleukin-1β, interleukin-6, tumor necrosis factor-α, interferon-γ, and inducible nitric oxide synthase. These consistent molecular, histopathological, and biochemical data suggest that AuNPs could ameliorate infection-induced damage in the livers of mice. Our results indicated that AuNPs are effective anti-schistosomal and antioxidant agents. Further confirmation of the role of nanogold as an anti-schistosomal agent, as well as its mechanism of action, requires further studies to be undertaken in the future.

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Quartz Crystal Microbalance in Bioanalysis

Naal

2021

Tools and Trends in Bioanalytical Chemistry

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The role of nanogold in human tropical diseases: research, detection and therapy

Cited by 5 publications

References 82 publications

Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics

Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics

Antioxidant and hepatoprotective role of gold nanoparticles against murine hepatic schistosomiasis

Quartz Crystal Microbalance in Bioanalysis

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