The influence of natural dicarbonils on the antioxidant enzymes activity in vitro and in vivo

Vz, Lankin; Gg, Konovalova; Ak, Tikhaze; Lv, Nedosugova

doi:10.18097/pbmc20125806727

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…A number of studies have shown that MG triggers oxidative stress in cells[27], [28]. In oocytes, high ROS content may damage DNA and protein, interfere with the metabolism energy sources, alter the lipid fusibility and then inhibit oocyte maturation.…”

Section: Resultsmentioning

confidence: 99%

“…MG can generate ROS induced by autoxidation[27]. Besides, MG could further modify some enzymes such as superoxide dismutases, glutathione peroxidases and glutathione transferases which result in a decreasing antioxidant defense way[28]. Through interaction with large molecules, MG produces various toxic substances which are so called AGEs and then cumulatively lead to more cellular oxidative stress[5].…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage

Liu

Huang

et al. 2013

PLoS ONE

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Methylglyoxal, a reactive dicarbonyl compound, is mainly formed from glycolysis. Methylglyoxal can lead to the dysfunction of mitochondria, the depletion of cellular anti-oxidation enzymes and the formation of advanced glycation ends. Previous studies showed that the accumulation of methylglyoxal and advanced glycation ends can impair the oocyte maturation and reduce the oocyte quality in aged and diabetic females. In this study, we showed that resveratrol, a kind of phytoalexin found in the skin of grapes, red wine and other botanical extracts, can alleviate the adverse effects caused by methylglyoxal, such as inhibition of oocyte maturation and disruption of spindle assembly. Besides, methylglyoxal-treated oocytes displayed more DNA double strands breaks and this can also be decreased by treatment of resveratrol. Further investigation of these processes revealed that methylglyoxal may affect the oocyte quality by resulting in excessive reactive oxygen species production, aberrant mitochondrial distribution and high level lipid peroxidation, and resveratrol can block these cytotoxic changes. Collectively, our results showed that resveratrol can protect the oocytes from methylglyoxal-induced cytotoxicity and this was mainly through the correction of the abnormity of cellular reactive oxygen species metabolism.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage

Liu

Huang

et al. 2013

PLoS ONE

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Effect of Talatisamine and its Derivate 14-O-Benzoyltalatisamine on Functional State of Rat Liver and Heart Mitochondria

Muratova,

Ergashev,

Asrarov

2023

Biomed. Pharmacol. J.

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Dysfunction of the mitochondria of various tissues causes the development of most pathological processes, including ischemia. In recent years, great attention has been paid to the use of plant biologically active substances in the prevention and treatment of pathological processes related to mitochondrial dysfunction. This is very relevant in relation to ischemic diseases and is of scientific and practical importance in the search for new pharmacological agents that correct the functions of damaged mitochondria for their treatment. The mitochondrial permeability transition pore (mPTP) actively participates in the regulation of mitochondrial functions, in the development of various pathological conditions and, at the same time, targets for various drugs and some biologically active substances. In vitro experiments evaluated the effects of alkaloids talatisamine and 14-O-benzoyltalatisamine on rat liver and heart Ca2+-dependent mPTP and lipid peroxidation (LPO) induced by Fe2+/ascorbate system. The investigated diterpenealkaloids inhibited the opening of the Ca2+-dependent mPTP in the membranes of rat liver and heart mitochondria. It was found that 14-O-benzoyltalatizamine inhibits the Ca2+-dependent conductance pore of rat liver and heart mitochondria more strongly than talatisamine. To compare the effects of 14-O-benzoyltalatisamine on rat liver and heart mPTP, concentrations from 1 μM to 200 μM were investigated. At these concentrations, liver mPTP was reliably inhibited by 10% to 81% and heart mPTP by 3.6% to 71.5% relative to control. The high sensitivity of diterpene alkaloids to the Ca2+-dependent permeability transition pore of liver mitochondria compared to heart mitochondria indicates their tissue specificity. The investigated alkaloids exhibited antioxidant properties by inhibiting Fe2+/ascorbate-induced mitochondrial suppression (LPO process) and MDA formation in membranes. LPO induced by Fe2+/ascorbate system in mitochondrial membranes was more actively inhibited by 14-O-benzoyltalatisamine. According to the results of the research, acylation of the hydroxyl group at the C-14 position of talatisamine by benzoyl chloride caused a rise in molecular activity of the derivative due to the introduction of the benzoyl group.

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The dynamics of indicators of peroxide metabolism in patients with cicatricial skin deformations in combination with metabolic syndrome in complex use of physiotherapeutic treatment methods and drinking mineral waters

Kazatseva¹,

Nagornev²,

Frolkov³

et al. 2021

Fizioterapevt (Physiotherapist)

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The article analyzes the role of lipid peroxidation processes in the pathogenesis of cicatricial skin changes, including in patients with metabolic syndrome. Baseline indices of LPO processes and antioxidant enzymes in patients with metabolic syndrome indicate the development of oxidative stress and accumulation of cytotoxic carbonyl products. The course use of a combination of fermenkol phonophoresis, fractional photothermolysis and mineral water «Essentuki №17» in patients with cicatricial changes in the skin and metabolic syndrome is accompanied by a decrease in the severity of insulin resistance and lipid peroxidation processes. The use of a complex of physiotherapeutic factors and drinking mineral water contributes to an increase in the coefficient of antioxidant protection by 54%. The revealed dynamics of the assessed parameters is realized due to the elimination of molecular inhibitors of antioxidant enzymes in conditions of an increase in the receptor sensitivity of tissues to insulin and a decrease in the level of glycemia. The manifestation of antioxidant activity in the combined use of physiotherapeutic methods and mineral waters for drinking purposes allows this technology to be considered as an effective means of pathogenetic therapy of cicatricial deformities of the skin in combination with metabolic syndrome.

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The influence of natural dicarbonils on the antioxidant enzymes activity in vitro and in vivo

Cited by 3 publications

References 29 publications

Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage

Resveratrol Protects Mouse Oocytes from Methylglyoxal-Induced Oxidative Damage

Effect of Talatisamine and its Derivate 14-O-Benzoyltalatisamine on Functional State of Rat Liver and Heart Mitochondria

The dynamics of indicators of peroxide metabolism in patients with cicatricial skin deformations in combination with metabolic syndrome in complex use of physiotherapeutic treatment methods and drinking mineral waters

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