The influence of naloxone on analgesia produced by peripheral conditioning stimulation

Sjölund, Bengt H.; Eriksson, Mats

doi:10.1016/0006-8993(79)90629-2

Cited by 316 publications

(76 citation statements)

References 29 publications

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“…This supposition was based on numerous studies [1;10;13;14;17;24 ;29] which revealed that the analgesic properties of high-frequency TENS could not be reversed by low doses of naloxone. On the opposite, other reports showed that the same doses of naloxone could block the analgesic effect of low-frequency/ high-intensity TENS (also-called acupuncture-like TENS) [7;17;23;29] leading to the premise that low-frequency TENS analgesia was produced via mechanisms utilizing endogenous opioids whereas high-frequency TENS analgesia was mediated via some other mechanism [24].…”

Section: Discussionmentioning

confidence: 99%

Deciphering the role of endogenous opioids in high-frequency TENS using low and high doses of naloxone

Léonard

Goffaux

Marchand

2010

Pain

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Section: Discussionmentioning

confidence: 99%

Deciphering the role of endogenous opioids in high-frequency TENS using low and high doses of naloxone

Léonard

Goffaux

Marchand

2010

Pain

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“…4,5 Similarly, in human subjects, systemic blockade of opioid receptors with naloxone prevents low-, but not high-, frequency TENS analgesia. 2 In animals, higher concentrations of systemic naloxone also prevent the effects of high-frequency TENS analgesia, 12,20 and blockade of δ-opioid receptors in the spinal cord or the RVM prevents the antihyperalgesia produced by highfrequency TENS in arthritic rats. 4,5 In parallel, opioid peptides are released in the cerebrospinal fluid and plasma in humans in response to either low-or high-frequency TENS in a frequencydependent manner.…”

Section: Discussionmentioning

confidence: 99%

“…Several early studies suggested that TENS activates opioid and serotonin receptors to produce analgesia in humans 2 and animals. 3 These initial animal studies used animals without tissue injury.…”

mentioning

confidence: 99%

Increased Release of Serotonin in the Spinal Cord During Low, But Not High, Frequency Transcutaneous Electric Nerve Stimulation in Rats With Joint Inflammation

Sluka

Lisi

Westlund

2006

Archives of Physical Medicine and Rehabilitation

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Objective-To determine the release pattern of serotonin and noradrenaline in the spinal cord in response to transcutaneous electric nerve stimulation (TENS) delivered at low or high frequency.Design-Prospective randomized allocation of 3 treatments. Setting-Research laboratory. Animals-Male Sprague-Dawley rats (weight range, 250-350g).Intervention-Knee joints of rats were inflamed with a mixture of 3% carrageenan and 3% kaolin for 24 hours prior to placement of push-pull cannulae into the dorsal horn of the spinal cord. Pushpull samples were collected in 10-minute intervals before, during, and after treatment with lowfrequency TENS (4Hz), high-frequency TENS (100Hz), or sham TENS. TENS was applied to the inflamed knee joint for 20 minutes at sensory intensity and 100-μs pulse duration. Push-pull samples were analyzed for serotonin and noradrenaline by high performance liquid chromatography with coulemetric detection. Main Outcome Measures-Spinal concentrations of serotonin and noradrenaline.Results-Low-frequency TENS significantly increased serotonin concentrations during and immediately after treatment. There was no change in serotonin with high-frequency TENS, nor was there a change in noradrenaline with low-or high-frequency TENS.Conclusions-Low-frequency TENS releases serotonin in the spinal cord to produce antihyperalgesia by activation of serotonin receptors. KeywordsHyperalgesia; Pain; Rehabilitation; Serotonin; Transcutaneous electric nerve stimulation TRANSCUTANEOUS ELECTRIC NERVE stimulation (TENS) is a common yet important nonpharmacologic treatment used as an adjunct treatment for a variety of painful conditions by health care practitioners. TENS is the application of surface electrodes to the skin for pain

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“…It is considered an efficient, easy-to-use, noninvasive, non-toxic and relatively low-cost procedure which, however, is poorly corroborated by non-controlled randomized studies [7][8][9] . Few studies report the secondary effects of the use of TENS, and most of them are not related to cardiac surgery.…”

mentioning

confidence: 99%

Estimulação elétrica nervosa transcutânea de curta duração no pós-operatório de cirurgia cardíaca

Gregorini

Cipriano

Aquino

et al. 2010

Arq. Bras. Cardiol.

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Background: Respiratory muscle strength has been related to the postoperative outcome of cardiac surgeries. The main documented therapeutic purpose of transcutaneous electrical nerve stimulation (TENS) is the reduction of pain, which could bring secondary benefits to the respiratory muscles and, consequently, to lung capacities and volumes.Objectives: The objective of the present study was to evaluate the effectiveness of short-duration transcutaneous electrical nerve stimulation (TENS) in the reduction of pain and its possible influence on respiratory muscle strength and lung capacity and volumes of patients in the postoperative period of cardiac surgery.Methods: Twenty five patients with mean age of 59.9 ± 10.3 years, of whom 72% were men, and homogeneous as regards weight and height, were randomly assigned to two groups. One group received therapeutic TENS (n = 13) and the other, placebo TENS (n = 12), for four hours on the third postoperative day of cardiac surgery. Pain was analyzed by means of a visual analogue scale, and of respiratory muscle strength as measured by maximum respiratory pressures and lung capacity and volumes before and after application of TENS. Results

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The influence of naloxone on analgesia produced by peripheral conditioning stimulation

Cited by 316 publications

References 29 publications

Deciphering the role of endogenous opioids in high-frequency TENS using low and high doses of naloxone

Deciphering the role of endogenous opioids in high-frequency TENS using low and high doses of naloxone

Increased Release of Serotonin in the Spinal Cord During Low, But Not High, Frequency Transcutaneous Electric Nerve Stimulation in Rats With Joint Inflammation

Estimulação elétrica nervosa transcutânea de curta duração no pós-operatório de cirurgia cardíaca

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