The influence of MTHFR C677T polymorphism in chronic lymphocytic leukemia

Reis, Ângela Adamski da Silva; Alcântara, Keila Correia de; Farias, Danielle Leão Cordeiro de; Anjos, Laura Raniere Borges dos; Rodrigues, D.A.; Pedrino, Gustavo Rodrigues; Santos, Rodrigo da Silva

doi:10.1002/elps.201800402

Cited by 6 publications

(5 citation statements)

References 25 publications

(37 reference statements)

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“…This result is associated especially with the elderly male (Rodrigues et al, 2016;Hallek et al, 2019). It is suggested that this type of neoplasia presents a higher prevalence in male, being more common with advancing age, especially in Western countries (Reis et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Short Communication Implications of GSTM1, GSTT1, and GSTP1 polymorphisms for susceptibility to chronic lymphocytic leukemia

Reis¹,

Alcântara²,

Souza³

et al. 2021

Genet. Mol. Res.

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possible genetic associations between GSTM1/GSTT1 deletion and GSTP1 rs1695 polymorphisms with CLL risk in a central Brazilian population. For GSTM1/GSTT1 deletion polymorphism, genotyping was performed with multiplex real-time PCR (qPCR), and for GSTP1 rs1695 polymorphism, PCR-RFLP was used. The GSTM1 null genotype presented a trend towards CLL risk. However, GSTT1 deletion polymorphism presented a protective effect for CLL (OR=0.26, p<0.005).The GSTP1 rs1695 was not associated with disease susceptibility. Among confounding factors, male gender and age was associated with a 2.42-fold and 1.06-fold increased risk of CLL, respectively. In conclusion, among the polymorphisms that were evaluated, the GSTM1 deletion polymorphism apparently helpsin the detoxification process and has a protective effect against CLL.

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Section: Discussionmentioning

confidence: 99%

“…Catovsky et al (2014) suggested that differences between the gender for development and response to therapy in CLL may be associated with the effect of estrogen level. Moreover, a Brazilian study demonstrated that age is linked to CLL predisposition for Methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP (Reis et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Short Communication Implications of GSTM1, GSTT1, and GSTP1 polymorphisms for susceptibility to chronic lymphocytic leukemia

Reis¹,

Alcântara²,

Souza³

et al. 2021

Genet. Mol. Res.

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show abstract

Section: Discussionmentioning

confidence: 99%

“…Genetic variants of angiogenesis factors can influence the expression of the corresponding proteins, and thus modify susceptibility to and severity of cancer. Indeed, some authors suggest an association between polymorphisms and predisposition to B-CLL development [38,39] and formation of specific chromosomal aberrations [40]. Other researchers have described some polymorphisms variants linked with the prediction of clinical outcome [41].…”

Section: Discussionmentioning

confidence: 99%

Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia

Ballester

Pineda

Rodrigues

et al. 2020

Genes

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Angiogenesis process contributes to the pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL) being the levels of VEGFA and bFGF higher in patients than in healthy controls. Our aim was to evaluate the implication of angiogenesis factors genetic variants in the predisposition to B-CLL and their association with clinical factors and survival. We performed a population-based case-control study in 224 Spanish B-CLL patients and 476 healthy randomly selected controls to evaluate susceptibility to developing B-CLL. Six polymorphisms were evaluated: rs1109324, rs1547651, rs3025039 (+936 C>T), rs833052 of the VEGFA gene, rs1449683 (c.233C>T) of the bFGF gene and (−710 C>T) of the VEGFR1 gene. The association between clinical parameters and patient outcome was analyzed. Carriers of the CT/TT variants of rs3025039 showed a significant protective effect against developing B-CLL. The CT/TT variants of rs1449683 show a tendency towards the development of the disease and the same variants associated significantly with higher genetic risk and with reduced disease free survival. Moreover, the association persisted in the early-stage disease subgroup. Our study provides evidence of the protective effect of the T/- rs3025039 VEGFA variant against B-CLL development and the association of CT/TT variants of the rs1449683 bFGF gene with genetic risk and an adverse survival.

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“…The results were observed in PAGE stained with silver nitrate. The PCR‐RFLP technique is widely used for genotyping because it is a simple procedure, low cost and high reproducibility when compared to other molecular methods 11,12 …”

Section: Methodsmentioning

confidence: 99%

One‐carbon metabolism pathway genes and their non‐association with the development of amyotrophic lateral sclerosis

Lima

Costa

Assunção

et al. 2022

J of Cellular Biochemistry

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Although of unknown etiology, some mechanisms associated with the metabolic cycle of folate are speculated to be related to the genesis of amyotrophic lateral sclerosis (ALS). Thus, the aim of the study was to analyze the role of genetic polymorphisms rs1051266 in SLC19A1 gene and rs1805087 in MTR gene and their associations with ALS development. A case–control study was conducted with 101 individuals with ALS and 119 individuals without diagnosis of neurodegenerative diseases, from the Brazilian central population. The polymorphisms were determined using the polymerase chain reaction‐restriction fragment length polymorphism technique. The results showed no statistically significant differences, even when genotypes were analyzed by the dominant, recessive, codominant, and overdominant inheritance models. It was observed a statistical significance relating alcohol consumption with individuals in the case group (p = 0.01). Therefore, the need for more studies to evaluate the influence of genetic variants is highlighted, seeking to provide information on the etiopathogenesis of ALS.

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The influence of MTHFR C677T polymorphism in chronic lymphocytic leukemia

Cited by 6 publications

References 25 publications

Short Communication Implications of <i>GSTM1</i>, <i>GSTT1</i>, and <i>GSTP1</i> polymorphisms for susceptibility to chronic lymphocytic leukemia

Short Communication Implications of <i>GSTM1</i>, <i>GSTT1</i>, and <i>GSTP1</i> polymorphisms for susceptibility to chronic lymphocytic leukemia

Clinical Relevance of +936 C>T VEGFA and c.233C>T bFGF Polymorphisms in Chronic Lymphocytic Leukemia

One‐carbon metabolism pathway genes and their non‐association with the development of amyotrophic lateral sclerosis

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