The Influence of MicroRNAs on Mitochondrial Calcium

Giusti, C; Román, Bárbara; Das, Samarjit

doi:10.3389/fphys.2018.01291

Cited by 20 publications

(13 citation statements)

References 85 publications

(117 reference statements)

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“…Among them, miR-762 was demonstrated to decrease intracellular ATP levels and to increase ROS levels in cardiomyocytes [47]. Although other nuclear-encoded miRNAs may also regulate mitochondrial signaling and function [48], mitomiRs play a crucial role in post-transcriptional regulation of gene expression related to mitochondrial function (e.g., energetics and apoptosis). It is of interest to investigate the interaction of mitomiRs and other nuclear-encoded miRNAs to consummate the molecular mechanisms underlying relevant diseases in the future.…”

Section: Mitomirs and Mitochondrial Energy Metabolismmentioning

confidence: 99%

“…AntimiR-146a treatment during pressure overload can give beneficial effects by de-repressing DLST to create a favorable metabolic profile with preserved both glucose oxidation and fatty acid oxidation in cardiomyocytes, which leads to diminished hypertrophy and an improvement in cardiac function [67]. Recently, miR-1 was found to effectively bind to the mitochondrial calcium uniporter (MCU) mRNA to influence mitochondrial Ca 2+ flux, contributing to cardiac hypertrophy [48]. In addition, miR-30 has been reported to antagonize apoptosis of cardiac cells through negatively regulating Drp1, an initiator of mitochondrial fission, Bcl-2, and Bnip3L/Nix, leading to apoptosis [55,68].…”

Section: Cardiac Hypertrophymentioning

confidence: 99%

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Mitochondrial MiRNA in Cardiovascular Function and Disease

Song

Zhang

2019

Cells

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MicroRNAs (miRNAs) are small noncoding RNAs functioning as crucial post-transcriptional regulators of gene expression involved in cardiovascular development and health. Recently, mitochondrial miRNAs (mitomiRs) have been shown to modulate the translational activity of the mitochondrial genome and regulating mitochondrial protein expression and function. Although mitochondria have been verified to be essential for the development and as a therapeutic target for cardiovascular diseases, we are just beginning to understand the roles of mitomiRs in the regulation of crucial biological processes, including energy metabolism, oxidative stress, inflammation, and apoptosis. In this review, we summarize recent findings regarding how mitomiRs impact on mitochondrial gene expression and mitochondrial function, which may help us better understand the contribution of mitomiRs to both the regulation of cardiovascular function under physiological conditions and the pathogenesis of cardiovascular diseases.

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Section: Mitomirs and Mitochondrial Energy Metabolismmentioning

confidence: 99%

Section: Cardiac Hypertrophymentioning

confidence: 99%

Mitochondrial MiRNA in Cardiovascular Function and Disease

Song

Zhang

2019

Cells

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“…Mitochondrial calcium uniport has a documented, crucial role in both proliferation and apoptosis [for reviews see e.g., ( De Stefani et al, 2015 ; Bustos et al, 2017 ; Cui et al, 2017 ; Bachmann et al, 2019 )]. The expression of the MCU subunit can be post-transcriptionally down-regulated by several small non-coding regulatory RNAs (miR), miR-25, and miR-138 ( Marchi et al, 2013 ; Hong et al, 2017 ; Jaquenod De Giusti et al, 2018 ; Figure 1 ). The miRs drastically decrease MCU protein levels, blocking thus mitochondrial Ca 2+ uptake without affecting [Ca 2+ ] C and [Ca 2+ ] ER , causing reduced apoptosis in cancer cells.…”

Section: The Mitochondrial Calcium Fluxes and Their Regulation In Celmentioning

confidence: 99%

Mitochondrial Ion Channels of the Inner Membrane and Their Regulation in Cell Death Signaling

Urbani

Prosdocimi

Carrer

et al. 2021

Front. Cell Dev. Biol.

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Mitochondria are bioenergetic organelles with a plethora of fundamental functions ranging from metabolism and ATP production to modulation of signaling events leading to cell survival or cell death. Ion channels located in the outer and inner mitochondrial membranes critically control mitochondrial function and, as a consequence, also cell fate. Opening or closure of mitochondrial ion channels allow the fine-tuning of mitochondrial membrane potential, ROS production, and function of the respiratory chain complexes. In this review, we critically discuss the intracellular regulatory factors that affect channel activity in the inner membrane of mitochondria and, indirectly, contribute to cell death. These factors include various ligands, kinases, second messengers, and lipids. Comprehension of mitochondrial ion channels regulation in cell death pathways might reveal new therapeutic targets in mitochondria-linked pathologies like cancer, ischemia, reperfusion injury, and neurological disorders.

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“…In vitro and in vivo studies confirm the involvement of microRNAs in the pathogenesis of kidney diseases ( Srivastava et al, 2019a ; Metzinger-Le Meuth et al, 2019 ; Nascimento and Domingueti, 2019 ). Several microRNAs play a crucial role in mitochondria ( Gomez et al, 2013 ; Jaquenod De Giusti et al, 2018 ; Bai et al, 2019 ). MiR-30e is suppressed in renal fibrosis, and its antagonism exerts an antifibrotic effect by targeting mitochondrial protein UCP2 ( Jiang et al, 2013a ).…”

Section: Mitochondria-targetted Therapeutics In Kidney Diseasesmentioning

confidence: 99%

Loss of Mitochondrial Control Impacts Renal Health

2020

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Disruption of mitochondrial biosynthesis or dynamics, or loss of control over mitochondrial regulation leads to a significant alteration in fuel preference and metabolic shifts that potentially affect the health of kidney cells. Mitochondria regulate metabolic networks which affect multiple cellular processes. Indeed, mitochondria have established themselves as therapeutic targets in several diseases. The importance of mitochondria in regulating the pathogenesis of several diseases has been recognized, however, there is limited understanding of mitochondrial biology in the kidney. This review provides an overview of mitochondrial dysfunction in kidney diseases. We describe the importance of mitochondria and mitochondrial sirtuins in the regulation of renal metabolic shifts in diverse cells types, and review this loss of control leads to increased cell-to-cell transdifferentiation processes and myofibroblast-metabolic shifts, which affect the pathophysiology of several kidney diseases. In addition, we examine mitochondrial-targeted therapeutic agents that offer potential leads in combating kidney diseases.

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The Influence of MicroRNAs on Mitochondrial Calcium

Cited by 20 publications

References 85 publications

Mitochondrial MiRNA in Cardiovascular Function and Disease

Mitochondrial MiRNA in Cardiovascular Function and Disease

Mitochondrial Ion Channels of the Inner Membrane and Their Regulation in Cell Death Signaling

Loss of Mitochondrial Control Impacts Renal Health

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