Mitochondrial MiRNA in Cardiovascular Function and Disease

Song, Rui; Hu, Xiang‐Qun; Zhang, Li

doi:10.3390/cells8121475

Cited by 57 publications

(52 citation statements)

References 108 publications

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“…It is plausible that muted expression of Complex I—and therefore lower ROS production—permits SARS-CoV-2 propagation. Additional reports on respiratory viruses such as RSV have indicated that Complex I inhibition could promote efficient viral replication 27 . SARS-CoV-2 not only decreased expression to many NDUF family of genes, but also several mitochondrial ribosome protein related genes in primary cells and BALF, observations of which, however, did not carry over to cell lines.…”

Section: Discussionmentioning

confidence: 99%

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

Miller

Silverstein

Flores

et al. 2021

Sci Rep

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SARS-CoV-2 induces a muted innate immune response compared to other respiratory viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate immunity. Polypeptides encoded by open reading frames of SARS-CoV and SARS-CoV-2 have been shown to localize to mitochondria and disrupt Mitochondrial Antiviral Signaling (MAVS) protein signaling. Therefore, we hypothesized that SARS-CoV-2 would distinctly regulate the mitochondrial transcriptome. We analyzed multiple publicly available RNASeq data derived from primary cells, cell lines, and clinical samples (i.e., BALF and lung). We report that SARS-CoV-2 did not dramatically regulate (1) mtDNA-encoded gene expression or (2) MAVS expression, and (3) SARS-CoV-2 downregulated nuclear-encoded mitochondrial (NEM) genes related to cellular respiration and Complex I.

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Section: Discussionmentioning

confidence: 99%

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

Miller

Silverstein

Flores

et al. 2021

Sci Rep

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“…Some of these miRs are known to act on mitochondria and regulate mitochondrial biogenesis, dynamics, and mitophagy (Amakiri et al., 2019). Recent studies on mitochondrial miRs have revealed insights into their importance in regulating mitochondrial dynamics under different pathological conditions (Dewanjee & Bhattacharjee, 2018; John et al., 2020; Reddy, Manczak, et al., 2017; Song et al., 2019). Barrey and co‐workers (2011) identified 169 miRs in mitochondria, which are thought to regulate polypeptide genes in the mitochondrial genome, energy production, and oxidative phosphorylation.…”

Section: Failure Of the Ubiquitin–proteasome System In Neurodegeneratmentioning

confidence: 99%

Mitochondrial dysfunction, mitophagy, and role of dynamin‐related protein 1 in Alzheimer's disease

Medala

Gollapelli

Dewanjee

et al. 2021

J of Neuroscience Research

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Alzheimer's disease (AD) is the most common type of dementia and progressive neurodegenerative disease. The presence of β-amyloid (Aβ) plaques and phosphorylated Tau tangles are considered to be the two main hallmarks of AD. Recent findings have shown that different changes in the structure and dynamics of mitochondria play an important role in AD pathology progression. Mitochondrial changes in AD are expressed as enhanced mitochondrial fragmentation, altered mitochondrial dynamics, and changes in the expression of mitochondrial biogenesis genes in vitro and in vivo models. Therefore, targeting mitochondria and associated mitochondrial proteins seems to be a promising alternative instead of targeting Aβ and Tau in the prevention of Alzheimer's disease. The dynamin-related protein (Drp1) is one such protein that plays an important role in the regulation of mitochondrial division and maintenance of mitochondrial structures. Few researchers have shown that inhibition of Drp1 GTPase activity in neuronal cells rescues excessive mitochondrial fragmentation. In addition, the growing evidence revealed that Drp1 can interact with both Aβ and Tau protein in human brain tissues and mouse models. In this review, we would like to update existing knowledge about various changes in and around mitochondria related to the pathogenesis of Alzheimer's disease, with particular emphasis on mitophagy and autophagy. | 1121 MEDALA Et AL.

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“…MicroRNA, a Direct Attack on the Viral Genome The miRNAs are small, non-coding, single-stranded RNA molecules, which are known to modulate a variety of vital physiological processes including RNA silencing, post-transcriptional regulators of gene expression involved in cardiovascular development and health [70][71][72][73][74][75]. Several thousand human genes, amounting to about one third of the whole genome, are potential targets for regulation by the several hundred miRNAs encoded in the genome [76].…”

Section: Current Therapeutic Strategies For the Development Of An Effmentioning

confidence: 99%

Therapeutic Strategies in the Development of Anti-viral Drugs and Vaccines Against SARS-CoV-2 Infection

Bhatti

Khullar³

et al. 2020

Mol Neurobiol

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The whole world is currently facing a pandemic of an infectious disease known as novel coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This outbreak emerged unexpectedly and imposed a potential threat to humans, associated with the social and economic burden on the individual and federal governments. COVID-19, which initially started in Wuhan City of China and then spread to the whole world, has been declared a Public Health Emergency of International Concern. The continuous increase in the number of confirmed cases leads to high mortality across the world. Growing evidence indicates that the mortality rate is very predominant in elderly people and those with preexisting health conditions. However, the potential pathogenesis of SARS-CoV-2 infection in humans is still unknown. The dysregulated/exuberant immune response may have substantially contributed to the SARS-CoV-2-mediated pathology. Nevertheless, there is no clinically approved drug/vaccine currently available that can restrict its pathogenesis. However, several drugs are currently shown to provide some therapeutic benefits for COVID-19 patients, including antiviral drugs that might have a significant role in restricting the current pandemic of COVID-19. In this article, we highlighted the pharmacological treatment strategies for COVID-19 and purposed the therapeutic targets for the development of vaccines or anti-viral drug molecules against SARS-CoV-2 infection in humans.

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Mitochondrial MiRNA in Cardiovascular Function and Disease

Cited by 57 publications

References 108 publications

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

Mitochondrial dysfunction, mitophagy, and role of dynamin‐related protein 1 in Alzheimer's disease

Therapeutic Strategies in the Development of Anti-viral Drugs and Vaccines Against SARS-CoV-2 Infection

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