The influence of mechanical vibratory stimulation and transcutaneous electrical nerve stimulation on experimental pruritus induced by histamine

Ekblom, A.; Fjellner, B; Hansson, Per

doi:10.1111/j.1748-1716.1984.tb07520.x

Cited by 31 publications

(6 citation statements)

References 22 publications

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“…It is likely that the irritation is caused by the spiky nature of wool fibres itself. Mechanical vibration seems to be irrelevant for induction of itch because it inhibits experimental, histamine‐induced itch (219). Interestingly, thicker wool fibres were found to provoke more intense itching than thinner fibres (220).…”

Section: Trigger Factors Aggravating Pruritus Perception In Atopic Dementioning

confidence: 99%

Pathophysiology and therapy of pruritus in allergic and atopic diseases

Buddenkotte

Steinhoff

2010

Allergy

116

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To cite this article: Buddenkotte J, Steinhoff M. Pathophysiology and therapy of pruritus in allergic and atopic diseases. Allergy 2010; 65: 805-821. Itch transmission by the nervous systemThe skin constitutes a barrier between 'outside' environment and 'inner' body. Therefore, one of its main tasks is to protect the organism against harmful influences from the outside. To fullfil this task, the skin is armed with an effective communication and control system. In all layers of the skin, specialized sensory and efferent nerve branches appear to form an overall dense nerval network. One main 'outsideto-inside' interaction causes sensations of itch. Pruritus is regularly defined as an unpleasant sensation provoking the desire to scratch (1) and constitutes an essential feature of atopic dermatitis (AD) (2, 3).Based on early psychophysical studies on itch (4), it was believed that itch is nothing but a low-intensity pain. Concepts from those times declared that itch is enciphered in specific patterns of action potentials running through 'pain fibres' or that itch emerges from combinations of other primary sensory signals. However, it is clear at this stage that pruritoception is a distinct entity just as nociception is a distinct entity (5-8). Therefore, the new concept of itch transmission is based on an important proposition: the existence of a central itch-specific neuronal pathway, in other words, it envisages the existence of a sensory system for pruritoception that is distinct from the sensory system for nociception (Fig. 1).Pruritus can be triggered by localized, systemic, peripheral or central stimuli. To relay itch information to different cerebric areas is the specific function of a subpopulation of the dense nerval network in the skin, the unmyelienated C-polymodal nociceptive neurons (in general being histamine-sensitive). The free nerve endings referred to as cutaneous terminals reside in the epidermis, papillary dermis and around skin appendages and are qualified to apprehend endogenous or exogenous itch causing agents through an armada of relevant receptors. These receptors detect their corresponding 'itchy' ligands and send either an electrical signal to the central AbstractPruritus (itch) is a major characteristic and one of the most debiliating symptoms in allergic and atopic diseases and the diagnostic hallmark of atopic dermatitis. Pruritus is regularly defined as an unpleasant sensation provoking the desire to scratch. Although we achieved rather good knowledge about certain inducers of itch such as neuropeptides, amines, l-opioids, cytokines and proteases, for example, less is known about the pathophysiological specifities among the different diseases, and the therapeutic consequences which may derive thereoff. This review dissects the role of mediators, receptors and itch inhibitors on peripheral nerve endings, dorsal root ganglia, the spinal cord and the CNS leading to the amplification or -vice versasuppression of pruritus. As the treatment of pruritus in allergic and atopic skin disease is...

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Section: Trigger Factors Aggravating Pruritus Perception In Atopic Dementioning

confidence: 99%

Pathophysiology and therapy of pruritus in allergic and atopic diseases

Buddenkotte

Steinhoff

2010

Allergy

116

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“…It is likely that the irritation is caused by the spiky nature of wool fibers itself while wearing wool garments close to the skin. Mechanical vibration seems not to be responsible for induction of itch as it inhibits experimental, histamine‐induced itch (140). Thicker wool fibers were found to provoke more intense itching than thinner fibers and an additional redness after application of wool samples (141).…”

Section: Triggering Factors Modulating Pruritus Perception In Atopic mentioning

confidence: 99%

Pathophysiology of pruritus in atopic dermatitis: an overview

Ständer

Steinhoff

2002

Experimental Dermatology

218

176

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Pruritus is an essential feature of atopic dermatitis (AD) andImmunobiology of the Skin, University of the diagnosis of active AD cannot be made without the history of Münster, Münster, Germany itching. Because of the high impact on life quality, most of the patients measure the severity of eczema by the intensity of pruritus rather than appearance of skin lesions. However, although pruritus is a cardinal symptom of AD, its mechanism and association with the cutaneous nervous system is not completely understood. Recently, a considerable progress has been achieved in clarifying the complex pathophysiology of pruritus in AD. As a cutaneous sensory perception, itch requires

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“…Ultraviolet phototherapy is effective in AD and decreases itch (87). Mechanical vibration, transcutaneous electrical nerve stimulation, and acupuncture can inhibit experimental, histamine-induced itch (88,89). In the clinical situation, transcutaneous electrical nerve stimulation is of limited value (90), and vibration and acupuncture need further evaluation.…”

Section: Physical Modalitiesmentioning

confidence: 99%

Itch and Atopic Dermatitis: An Overview

Wahlgren

1999

The Journal of Dermatology

208

166

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Itching is the hallmark of atopic dermatitis, and a vicious itch-scratch circle is easily established. Itching and scratching are important factors in the maintenance of symptoms and can have a significant impact on the sufferer's quality of life. The pathophysiology of itch in atopic dermatitis is still not understood. Unlike in urticaria, histamine is not considered to be a major pruritogen in atopic dermatitis. In fact, the peripheral pruritogens and their cellular origin(s) still remain to be identified in this disease. Various treatments are used to relieve the skin inflammation, itching, and scratching in patients with atopic dermatitis, but no specific antipruritic therapy is available. However, several nonspecific therapies can effectively break the vicious itch-scratch circle. The use of topical corticosteroids and emollients and the elimination of individual trigger factors are still first-line measures.

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The influence of mechanical vibratory stimulation and transcutaneous electrical nerve stimulation on experimental pruritus induced by histamine

Cited by 31 publications

References 22 publications

Pathophysiology and therapy of pruritus in allergic and atopic diseases

Pathophysiology and therapy of pruritus in allergic and atopic diseases

Pathophysiology of pruritus in atopic dermatitis: an overview

Itch and Atopic Dermatitis: An Overview

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