The influence of maternal folate and iron deficiencies on intrauterine life

Pritchard, Jack A.; Whalley, Peggy J.; Scott, Daniel E.

doi:10.1016/s0002-9378(16)34191-6

Cited by 30 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the folate present in serum is free or loosely bound (Fernandez-Costa & Metz, 1979) and, presumably, is available for placental uptake. The Ka of 0.3 nM-that we observed for the saturable component of folate uptake by isolated placental microvilli is therefore consistent with reports that the foetal supply of folate may be adequate, at least for haematopoiesis, in the face of moderate maternal deficiency (Pritchard et al, 1969). However, recent evidence of a possible association between inadequate folate intake by the mother and neural-tube defects in the infant (Laurence et al, 1981) suggests that foetal demands may not always be entirely satisfied, particularly during certain critical periods of development.…”

Section: Discussionsupporting

confidence: 91%

Human placental microvilli contain high-affinity binding sites for folate

Green¹,

Ford²

1984

Biochemical Journal

View full text Add to dashboard Cite

Uptake of [3H]pteroylglutamic acid [( 3H]PteGlu) was studied in microvilli isolated from the syncytiotrophoblast of the human term placenta. The effect of changes in medium osmolality on the equilibrium uptake of [3H]PteGlu was negligible, which suggested that the observed uptake represented binding to proteins on or within the microvilli rather than translocation of the vitamin from the incubation medium to a free state in the intravesicular fluid. Equilibrium uptake experiments performed over a wide range of [3H]PteGlu concentrations disclosed a class of binding sites with an association constant of 0.3 nM-1 as well as a second class of sites with high capacity and low affinity. Binding of [3H]PteGlu at the high-affinity sites was inhibited by tetrahydrofolate and N5-methyltetrahydrofolate, but not by several other structural analogues. It is likely that the high-affinity binding sites are receptors for maternal plasma folate; however, their role in placental transport or storage of the vitamin was not delineated in these studies.

show abstract

Section: Discussionsupporting

confidence: 91%

Human placental microvilli contain high-affinity binding sites for folate

Green¹,

Ford²

1984

Biochemical Journal

View full text Add to dashboard Cite

show abstract

“…Efficacy of FA administration A relation between maternal folate status and reproductive performance is reported to exist in several species including humans (4,15,19), rats (21), guinea pigs (7), and pigs (6, 9,10,12,20,22,23). It has been considered that folate requirement increases during pregnancy (8).…”

Section: Plasma Active Folatesmentioning

confidence: 99%

“…Therefore, its deficiency causes dysfunctions in the replication of cells; for example, in the haematopoietic system these dysfunctions lead to megaloblastic anaemia (8,15,19). Since the folate level decreases in plasma before its tissue depletion, and this decrease in plasma is paralleled by a reduction in red blood cell folate, the levels in plasma are important clinical indicators that reflect the folate status of the body of many mammalian species (1, 2,5,8).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and bioavailability of folic acid and plasma levels of bioactive folates after folic acid administration to pigs

Kokue

Sekiya²,

Shimoda³

et al. 1994

Veterinary Quarterly

View full text Add to dashboard Cite

SUMMARYAfter intravenous (1 mg/kg body weight), intramuscular (1 mg/kg body weight) and oral (1 and 50 mg/kg body weight) administration of folic acid (FA) to pigs, plasma levels of FA, tetrahydrofolic acid (THF), 5-methyltetrahydrofolic acid (5MF) were determined by using highperformance liquid chromatography. The pharmacokinetic profile of plasma FA after oral administration indicated an absorption rate-limited elimination, i.e., so called 'flip-flop' phenomenon. The bioavailability of FA was quite low after a high oral dose (F=0.01), in contrast to a high value after intramuscular administration (F=0.95). The plasma levels of biologically active, reduced forms of folates (THF and 5MF) were significantly increased over their basal levels after IV and IM administration to FA. The levels of these active folates were not increased after oral administration of a similair dose of FA. A 50 times higher dose was required to increase the active folates to the levels observed after IV and IM administration.

show abstract

“…Surveys carried out in different parts of India indicate that more than 50% of women have nutritional anaemia in the later months of pregnancy mainly due to iron deficiency (5). Available evidence suggests that the foetus and the placenta quite effectively parasitize iron from the mother even when she is grossly deficient in this nutrient (7,9). Sturgeon (14) showed that the cord blood haemoglobin levels were similar in anaemic and non-anaemic mothers.…”

mentioning

confidence: 99%

Effect of Maternal Anaemia on the Placenta and the Newborn Infant

et al. 1978

View full text Add to dashboard Cite

Foetal birthweight, placental morphometry and maternal, cord blood and placental haemoglobin and iron levels were studied in 69 anaemic mothers (haemoglobin less than 110 g/l) and 16 mothers without anaemia (haemoglobin greater than or equal to 110 g/l). The birthweight, placental weight and number of placental cotyledons were significantly reduced in the severely anaemic mothers (haemoglobin less than or equal to 60 g/l) and had direct relationships with the maternal haemoglobin levels. However, placental volume and surface area showed no constant relation to maternal haemoglobin. The haemoglobin and iron levels in the cord blood and placental tissue were found to have linear correlations with the maternal haemoglobin levels. The low levels of placental and cord serum iron in the severely anaemic mothers suggest that iron supply to the placenta and the foetus is affected in maternal anaemia and the foetus takes iron in direct proportion to the levels available in the mother.

show abstract

The influence of maternal folate and iron deficiencies on intrauterine life

Cited by 30 publications

References 21 publications

Human placental microvilli contain high-affinity binding sites for folate

Human placental microvilli contain high-affinity binding sites for folate

Pharmacokinetics and bioavailability of folic acid and plasma levels of bioactive folates after folic acid administration to pigs

Effect of Maternal Anaemia on the Placenta and the Newborn Infant

Contact Info

Product

Resources

About