The Influence of Laparoscopic Sleeve Gastrectomy on Body Composition and Fat Distribution in Obese Caucasian Men and Women

Abstract

Background The aim of the study was to assess changes in body composition in patients subjected to laparoscopic sleeve gastrectomy (LSG). Methods Changes in body composition following LSG were determined in a group of 155 patients with obesity (117 women and 38 men), with dual-energy X-ray absorptiometry (DXA). Whole body fat mass (FM) and lean body mass (LBM) were determined, and abdominal fat mass (AbdF) was assessed within the region extending from the top of the pubic bone up to the line between 12th thoracic and 1st lumbar vertebras. Results Over the period of 12 months following LSG, body mass index decreased by 28.2 ± 9.0% (p < 0.001). The reduction of body weight by 35.4 ± 12.6 kg (p < 0.001) was the result of a decrease in FM by 23.9 ± 8.9 kg (p < 0.001) and LBM by 10.5 ± 3.8 kg (p < 0.001). AbdF decreased from 13.2 ± 3.1 to 8.2 ± 2.7 kg (p < 0.001), but abdominal fat to total fat mass ratio increased from 24.9 ± 4.7 to 28.0 ± 5.8% (p < 0.001). The loss of AbdF was more pronounced in men than in women. The rate of FM loss was attenuated with patients' age. Conclusions Over the period of 12 months following LSG, the reduction of FM was more than twice as much as decrease of LBM. The loss of AbdF was slower than a loss of peripheral subcutaneous fat.

Comparison of HIV-Infected and Noninfected Patients Undergoing Bariatric Surgery: The ObeVIH Study

“…Corresponding values in men were 43.1 kg/m 2 , 52.2 kg, and 38.4%. 29 These values are close to those observed in our HIV-negative population. Another Polish series studied patients undergoing BS for early-onset (age <20 y, n = 246) or late-onset obesity (age >20 y, n = 223).…”

Epigenetic Regulation of Estrogen Receptor Genes’ Expressions in Adipose Tissue in the Course of Obesity

“…Study participants were recruited from the Department of General and Transplantation Surgery; the Medical University of Warsaw; and the Department of General, Oncological and Bariatric Surgery, Medical Centre of Postgraduate Education Warsaw, as described previously [ 26 , 64 ]. The group of obese patients consisted of 78 individuals with a body mass index (BMI) > 40 kg/m 2 : 65 females (47 premenopausal and 18 postmenopausal) and 13 males, whose basic clinical and biochemical characteristics are summarized in Table 1 .…”

“…Real-time PCR was performed in a LightCycler 480 Instrument II (Roche, Mannheim, Germany) for mRNA analysis with a LightCycler 480 Sybr Green I Master Kit (Roche, Mannheim, Germany) [ 66 ]. The miRNA analysis was performed with a miRCURY™ LNA™ Universal RT microRNA PCR system (Qiagen, Hilden, Germany—previously Exiqon, Vedbaek, Denmark), which is a microRNA-specific system designed for detecting miRNA via quantitative real-time PCR using SYBR Green as previously described [ 26 , 64 , 65 ]. Briefly, 100 ng of total RNA was used to synthesize cDNA.…”

Effect of Weight Regain on Body Composition and Metabolic Biomarkers After Sleeve Gastrectomy: a Cross-Sectional Study from a Hospital Database

“…Several studies compared across groups the body composition and metabolic biomarkers using analysis of variance revealed an effect size of 0.25, 0.30, and 0.35, slightly close to the large effect size of 0.4 that is predicted. [ 17 , 18 ] In this study, we conducted multiple linear regressions; therefore, a large effect size of 0.35 was used with a (1-β) power of 80% at α = 0.05, yielding a minimum sample size of 56.…”