The influence of gene-chronic hepatitis C virus infection on hepatic fibrosis and steatosis

PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study

“…Age (years) however, extension of their implication in NAFLD-associated hepatic fibrosis is not definite [28] and is certainly debatable in the context of hepatic fibrosis and cirrhosis of viral (especially CHC) etiology [10,17,29,30]. Previously, several studies based on primarily Caucasian and some Asian datasets have suggested association of PNPLA3 risk variant with increased severity of hepatic fibrosis and cirrhosis [30,31] and enhanced progression of liver fibrosis or cirrhosis [29] or independent steatosis [10,32] in CHC settings. However, such evidence is relatively limited for TM6SF2 where only a couple of studies reported overrepresentation of TM6SF2 rs58542926 risk allele in CHC patients displaying hepatic scarring (fibrosis and cirrhosis) [30,33].…”

“…Previously, several studies based on primarily Caucasian and some Asian datasets have suggested association of PNPLA3 risk variant with increased severity of hepatic fibrosis and cirrhosis [30,31] and enhanced progression of liver fibrosis or cirrhosis [29] or independent steatosis [10,32] in CHC settings. However, such evidence is relatively limited for TM6SF2 where only a couple of studies reported overrepresentation of TM6SF2 rs58542926 risk allele in CHC patients displaying hepatic scarring (fibrosis and cirrhosis) [30,33]. Extension of PNPLA3 and TM6SF2 association has also been observed to hepatocellular carcinoma (HCC) [34] attributable to both viral [13] and non-viral [35,36] origin, and less commonly to alcoholic liver disease [9].…”

Influência dos polimorfismos nos genes Patatin-like Phospholipase Domain Containing 3 (PNPLA3) e Transmembrane 6 Superfamily Member 2 (TM6SF2) na hepatite C crônica

“…com esteatose e fibrose em pacientes com HCV, entretanto, a população não estava em equilíbrio de Hardy-Weinberg para este SNP (p= 0,000). (134) Assim como em nosso trabalho, algumas outras publicações também associação com esteatose, porém não com fibrose hepática. (73) Duas meta-análises publicadas com hepatite C, por sua vez, mostraram resultados compatíveis com aqueles descritos para a DHGNA.…”