The Influence of Gender on Cough Reflex Sensitivity

Dicpinigaitis, Peter V.; Rauf, Khalid

doi:10.1378/chest.113.5.1319

Cited by 151 publications

(112 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whilst Sherrill, Lebowitz, Knudson, and Burrows (1993) and Janson-Bjerklie, Carrieri, and Hudes (1986) reported gender differences in disease symptoms, Van den Boom et al (1998) found no such differences between COPD patients who did or did not consult their general practitioners concerning respiratory symptoms. Moreover, gender differences were also found in married people (Mookherjee, 1997), homeless people (Ritchey, La Gory, & Mullis, 1991) and with regard to sensitive cough reflex, in healthy subjects (Dicpinigaitis & Rauf, 1998).…”

Section: Introductionmentioning

confidence: 85%

Gender Differences in Sarcoidosis: Symptoms, Quality of Life, and Medical Consumption

2000

View full text Add to dashboard Cite

ABSTRACT. The aim of this study was to examine gender differences in quality of life (QOL) and in constitutional symptoms that coincide with sarcoidosis. The study population included 1026 sarcoidosis patients--all members of the Dutch Sarcoidosis Society--who completed the WHOQOL-100 and a symptom checklist. Women experienced more symptoms than men. With regard to QOL, male and female patients who suffered from symptoms differed in the broader domains of Physical Health and Psychological Health. Specific facets reflected pain, sleep, positive affect, appearance, mobility, and activities of daily living. Future studies should focus on the different experience of the disease between male and female patients more extensively. Studies are needed to evaluate whether the differences in the present study between male and female sarcoidosis patients are caused by a subject selection bias or life style differences; have a genetic, hormonal or biological base; or just are an epiphenomenon.

show abstract

Section: Introductionmentioning

confidence: 85%

Gender Differences in Sarcoidosis: Symptoms, Quality of Life, and Medical Consumption

2000

View full text Add to dashboard Cite

show abstract

“…With this technique, capsaicin concentrations (or other tussives such as citric acid and distilled water) are doubled until two and five "cough events" (typically defined by the number of expulsive events, or "cough sounds") are achieved, representing the threshold and suprathreshold response, respectively. These studies have shown differences in the cough response between ages [13], genders [14][15][16] and diseases [4,5,13,17]. However, these data cannot infer changes in expiratory muscle activation, duration of expulsive phases and the airflow dynamics with increasing capsaicin concentration, all which are essential components in defining the cough response.…”

Section: Introductionmentioning

confidence: 99%

Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner

Vovk

Bolser

Hey³

et al. 2007

Pulmonary Pharmacology & Therapeutics

View full text Add to dashboard Cite

The airway defensive response to tussive agents, such as capsaicin, is frequently assessed by counting the number of cough sounds, or expulsive events. This method does not identify or differentiate important respiratory events that occur in the respiratory muscles and lungs, which are critical in assessing airway defensive responses. The purpose of this study was to characterize the airway defensive behaviours (cough and expiration reflex) to capsaicin exposure in humans. We observed complex motor behaviours in response to capsaicin exposure. These behaviours were defined as cough reacceleration (CRn) and expiration reflex (ERn), where n is the number of expulsive events with and without a preceding inspiratory phase, respectively. Airway defensive responses were defined in terms of frequency (number of expulsive events), strength (activation of abdominal muscles) and behaviour type (CRn vs. ERn). Thirty-six subjects (15 females, 24±4 yr) were instrumented with EMG electrodes placed over the rectus abdominis (RA), external abdominal oblique (EO) and the 8th intercostal space (IC8). A custom-designed mouth pneumotachograph was used to assess the airflow acceleration, plateau velocity and phase duration of the expulsive phase. Subjects inhaled seven concentrations of capsaicin (5-200 μM) in a randomized block order. The total number of expulsive events (frequency) and the sum of integrated EMG for the IC8, RA and EO (strength) increased in a curvilinear fashion. Differentiating the airway defense responses into type demonstrated predominately CR1 and CR2 (i.e. inspiration followed by one and two expulsive events, respectively) with very few ER's at <50 μM capsaicin. At higher concentrations (>50 μM) ER's with one or more expulsive events (≥ER1) appeared, and the number of CR's with three or more expulsive events (≥CR3) increased. The decrease in EMG activation and airflow measurements with each successive expulsive event suggests a decline in power and shear force as the number of expulsive events increased. Therefore, the airway defensive response to capsaicin is a complex motor pattern that functions to coordinate ER's and CR's with differing numbers of expulsive events possibly to prevent aspirations and keep air moving to promote clearance.

show abstract

“…Healthy women have a more sensitive cough reflex than do healthy men [8,9], and women with chronic cough demonstrate an enhanced cough reflex compared with their male counterparts [10]. In terms of health-related quality of life, women are significantly more adversely affected by chronic cough than are men [11].…”

mentioning

confidence: 99%

Thoughts on One Thousand Chronic Cough Patients

Dicpinigaitis

2012

Lung

Self Cite

View full text Add to dashboard Cite

Cough is the most common complaint for which patients seek medical attention. Although most cases of acute cough, due to viral upper respiratory tract infection, are transient and self-limited, chronic cough often poses a diagnostic and therapeutic challenge. A subgroup of patients suffering from chronic cough will elude a diagnosis despite appropriate evaluation, and will prove refractory to all therapeutic intervention. Having personally evaluated 1000 individuals presenting to a specialty cough center, the author shares insights regarding the demographic composition of this unique group of patients, as well as clinical observations and opinions on currently unmet needs requiring further research.

show abstract

The Influence of Gender on Cough Reflex Sensitivity

Cited by 151 publications

References 9 publications

Gender Differences in Sarcoidosis: Symptoms, Quality of Life, and Medical Consumption

Gender Differences in Sarcoidosis: Symptoms, Quality of Life, and Medical Consumption

Capsaicin exposure elicits complex airway defensive motor patterns in normal humans in a concentration-dependent manner

Thoughts on One Thousand Chronic Cough Patients

Contact Info

Product

Resources

About