The influence of gait pattern on signs of knee osteoarthritis in older adults over a 5–11 year follow-up period: A case study analysis

Lynn, Scott K.; Reid, Susan A.; Costigan, Patrick A.

doi:10.1016/j.knee.2006.09.002

Cited by 64 publications

(66 citation statements)

References 27 publications

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“…It is noteworthy, however, that medications that afford pain relief in symptomatic knee OA concurrently modify the knee abductor moment (Henriksen et al, 2006;Schnitzer et al, 1993), thereby suggesting that gait modifications designed to help loading are likely to occur in people with knee pain. The knee abductor moment appears to be involved in the onset of chronic knee pain (Amin et al, 2004) and radiographic knee OA (Lynn et al, 2007) and is associated with a greater risk of radiographic OA progression (Miyazaki et al, 2002). On the basis of the results of this study, PFPS patients may be considered as a population at risk, from a biomechanical point of view, for the development of medial knee OA due to repetitive altered knee loading.…”

Section: Discussionmentioning

confidence: 86%

Kinematic and kinetic features of normal level walking in patellofemoral pain syndrome: More than a sagittal plane alteration

Paoloni

Mangone²,

Fratocchi

et al. 2010

Journal of Biomechanics

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Section: Discussionmentioning

confidence: 86%

Kinematic and kinetic features of normal level walking in patellofemoral pain syndrome: More than a sagittal plane alteration

Paoloni

Mangone²,

Fratocchi

et al. 2010

Journal of Biomechanics

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“…52 In the general population, mechanical loading of the knee joint during walking has been associated with the presence, severity, and progression of knee OA. [53][54][55][56] Persons with unilateral lower LL are 17 times more likely to suffer from knee OA in the intact limb when compared to able-bodied individuals. 57 As previously noted, persons with LL frequently develop altered movement patterns during gait.…”

Section: Osteoarthritismentioning

confidence: 99%

Impact of Traumatic Lower Extremity Injuries Beyond Acute Care: Movement-Based Considerations for Resultant Longer Term Secondary Health Conditions

Butowicz

Dearth

Hendershot

2017

Advances in Wound Care

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Significance: Advances in field-based trauma care, surgical techniques, and protective equipment have collectively facilitated the survival of a historically large number of service members (SMs) following combat trauma, although many sustained significant composite tissue injuries to the extremities, including limb loss (LL) and limb salvage (LS). Beyond the acute surgical and rehabilitative efforts that focus primarily on wound care and restoring mobility, traumatic LL and LS are associated with several debilitating longer term secondary health conditions (e.g., low back pain [LBP], osteoarthritis [OA], and cardiovascular disease [CVD]) that can adversely impact physical function and quality of life. Recent Advances: Despite recent advancements in prosthetic and orthotic devices, altered movement and mechanical loading patterns have been identified among persons with LL and salvage, which are purported risk factors for the development of longer term secondary musculoskeletal conditions and may limit functional outcomes and/or concomitantly impact cardiovascular health. Critical Issues: The increased prevalence of and risk for LBP, OA, and CVD among the relatively young cohort of SMs with LL and LS significantly impact physiological and psychological well-being, particularly over the next several decades of their lives. Future Directions: Longitudinal studies are needed to characterize the onset, progression, and recurrence of health conditions secondary to LL and salvage. While not a focus of the current review, detailed characterization of physiological biomarkers throughout the rehabilitation process may provide additional insight into the current understanding of disease processes of the musculoskeletal and cardiovascular systems.Keywords: amputation, biomechanics, cardiovascular disease, limb salvage, low back pain, osteoarthritis SCOPE AND SIGNIFICANCEExtremity trauma, including limb loss (LL) and limb salvage (LS), is commonly associated with an elevated risk for secondary health conditions (e.g., low back pain [LBP], osteoarthritis [OA], cardiovascular disease [CVD]) that can significantly limit physical function, reduce quality of life (QoL), and life expectancy. This review provides an extensive commentary regarding resultant secondary health effects of extremity trauma in service members (SMs), with a particular focus on functional outcomes and quality of movement. TRANSLATIONAL RELEVANCEPhysiologic biomarkers provide an opportunity to enhance translation in future work to examine the pathophysiology of the secondary health conditions associated with traumatic LL from a basic science perspective. While this approach is yet to be fully explored and thus was not a primary focus of this review, such biomarkers may augment traditional analyses and support more comprehensive risk characterization, thereby allowing clinicians and researchers to better mitigate disease onset or progression. CLINICAL RELEVANCEThe increased prevalence of secondary health effects following traumatic extremity injuries places a...

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“…Amin et al were able to assess 7 new cases of chronic knee pain out of 80 participants, and these were associated with high adduction moments during gait (7). Lynn et al found an association between malalignment and radiographic changes in a small group of 28 subjects (8).…”

Section: Introductionmentioning

confidence: 97%

Self‐reported knee and foot alignments in early adult life and risk of osteoarthritis

McWilliams¹,

Doherty²,

Maciewicz³

et al. 2010

Arthritis Care & Research

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Objective. To determine whether self-reported early adult life malalignment of knees or feet are risk factors for knee or hip osteoarthritis (OA). Methods. Participants in the Genetics of Osteoarthritis and Lifestyle case-control database were sent a questionnaire (n ‫؍‬ 3,022) containing line-drawing instruments for self-reported knee and foot alignment at ages 20 -29 years. Respondents were categorized as having straight, valgus, or varus knee, and straight, toe-in, or toe-out feet. Radiographic criteria were used to define current isolated knee or hip OA, combined knee and hip OA, or non-OA controls. Odds ratios (ORs), adjusted ORs, and 95% confidence intervals (95% CIs) were calculated and logistic regression was performed. Results. The response rate was 72%; 87.5% of responders (n ‫؍‬ 1,901) completed the alignment questions. Increased risk of isolated knee OA occurred with early adult varus (adjusted OR 5.16, 95% CI 2.87-9.41) and valgus knees (adjusted OR 3.16, 95% CI 1.04 -9.64). The positive association between knee OA and toe-in foot was explained by varus knee. There was an increased risk of combined knee/hip OA from varus (adjusted OR 4.52, 95% CI 2.39 -8.53) and valgus knees (adjusted OR 3.07, 95% CI 0.99 -9.54). Varus knee was associated with risk of medial tibiofemoral OA, whereas valgus knee was associated with risk of lateral tibiofemoral and lateral patellofemoral OA. Toe-out foot was associated with reduced medial patellofemoral OA. For knee OA, a multiplicative interaction analysis between occupational risks and varus/valgus yielded an OR int of 3.20 (95% CI 1.08 -9.49). Conclusion. Constitutional alignment of the leg in terms of varus or valgus knee or foot rotation may be a significant factor in determining development and distribution of knee but not hip OA.

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The influence of gait pattern on signs of knee osteoarthritis in older adults over a 5–11 year follow-up period: A case study analysis

Cited by 64 publications

References 27 publications

Kinematic and kinetic features of normal level walking in patellofemoral pain syndrome: More than a sagittal plane alteration

Kinematic and kinetic features of normal level walking in patellofemoral pain syndrome: More than a sagittal plane alteration

Impact of Traumatic Lower Extremity Injuries Beyond Acute Care: Movement-Based Considerations for Resultant Longer Term Secondary Health Conditions

Self‐reported knee and foot alignments in early adult life and risk of osteoarthritis

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