The influence of Escherichia coli 078 endotoxin on carbohydrate metabolism in the domestic fowl

Curtis, M.J.; Scott, B.W.; Butler, E.J.

doi:10.1016/s0034-5288(18)32608-0

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Additionally, the injection of endotoxin isolated from a pathogenic avian strain of Escherichia coli (1 mg/kg intravenously) accelerated the depletion of liver glycogen and was followed by hypoglycemia in chickens. In addition, changes in the plasma urate and albumin content indicated that glucose was synthesized from amino acids and that albumin was catabolized to provide these amino acids [ 43 ]. Acute exposure to LPS can cause transient hypoglycemia and insulin resistance by inhibiting hepatic glucose production through the TLR4, MyD88, and NFκB pathways [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Bacterial Lipopolysaccharide (LPS) on Turkey Poults: Assessment of Biochemical Parameters and Histopathological Changes

Elazab

Nasr

Ahmed

et al. 2022

Veterinary Sciences

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A lipopolysaccharide (LPS) is a large molecule and an outer membrane glycolipid found in Gram-negative bacteria, including Escherichia coli (E. coli). These molecules (LPS) target acute inflammatory responses and significant physiological changes. Importantly, E. coli is considered one of the most important bacterial causes of avian colibacillosis that affect domestic turkey industry. However, little information is available about the potential influence of LPS on the biochemical parameters and histopathological changes in turkey poults. Therefore, this study aimed to evaluate the influence of bacterial lipopolysaccharide (LPS) molecules on serum biomarkers and histopathological changes in turkey poults. The birds were randomly divided into five groups, as follows: group I did not receive any inoculation; group II was inoculated with sterile saline; and groups III, IV, and V were inoculated intraperitoneally with LPS at 0.01, 0.1, and 1 mg/kg of body weight (BW), respectively. The biochemical parameters and the histopathology of different organs were examined in all birds one day post-inoculation. Our results revealed hypolipidemia, hypoglycemia, a significant decrease in uric acid, and a significant increase in serum activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and creatine kinase (CK), as well as cardiac troponin T concentrations in treated groups. Moreover, there was a significant increase in α1-, β-, and γ-globulin concentrations and a decrease in albumin and α2-globulin concentrations in group V. However, a significant increase in α2- and γ-globulin levels and a decrease in albumin levels were detected in groups III and IV. In addition, significant decreases in the albumin/globulin ratio were recorded in all LPS-treated groups. Hepatocellular and cardiac muscle necrosis, slight renal changes, and massive pulmonary inflammatory reactions were recorded. This study provides valuable information about serum biomarkers, protein fractions, and histopathological changes in turkey poults treated with LPS for further investigations of pathophysiological mechanisms in avian medicine along with biomedical research.

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Section: Discussionmentioning

confidence: 99%