The Influence of Enzymes on Adhesive Processes in the Abdominal Cavity

Abstract

Our study found that oral poly-enzyme therapy following laparotomy and abrasion of the visceral and parietal peritoneum reduces the extent of postoperative intestinal adhesions. This favorable effect can be explained by the lower levels of angiogenic agents (VEGF, bFGF) and laminin after the administration of hydrolytic enzymes.

Basic Fibroblast Growth Factor in Scarless Wound Healing

“…2 On the contrary, in a rat study using oral polyenzyme therapy after laparotomy and abrasion of the visceral and parietal peritoneum reduces the extent of postoperative intestinal adhesions, and this favorable effect can be explained by the lower levels of angiogenic factors such as vascular endothelial growth factor and bFGF or laminin after the administration of hydrolytic enzymes. 8 Another study in a basal lamina gel incorporated in a neuroinflammation cell culture model and in a glial scarring around electrodes, serum and inflammatory factors to induce the neural progenitor cell activation and migration to the site of injury, where growth factors such as bFGF and PDGF induce proliferation of cells that eventually form the glial scar formation. 9,10 These scarring effects via bFGF may be due to the visceral and brain cells to external skin environmental differences, but even in the vocal fold scar models of a rat and in a canine, bFGF decreases the scar formation and improves clinical manifestations.…”

Endometrial Receptivity and Intrauterine Adhesive Disease

“…The women with IUA exhibited increased postoperative concentrations of transforming growth factor-beta, platelet-derived growth factor, and bfibroblast growth factor, all of which have been associated with adhesion formation. [16][17][18][19][20][21][22][23] This suggests that the production or expression of these cytokines, which are also modulators of inflammation, is aberrant in women with IUA and perhaps contributes to adhesion formation.…”

The prognostic value of bactericidal/ permeability-increasing protein in infants with congenital pathology of the gastrointestinal tract

“…Уровень BPI перед операцией в группе № 2 был выше, чем в группе № 1 (10.5 ng/ml (3,,05) и 3,33 ng/ml (2,74-4,51), p<0,05, соот-The level of BPI before surgery in group 2 was significantly higher than that in group 1 (10.5 ng/ml (3.35-19.05) and 3.33 ng/ml (2.74-4.51) p<0.05, respectively). In a group data comparison, BPI was significantly higher in group 1, even on the third day after surgery (2.915 ng/ml (1.37-55.5) and 15.75 ng/ml (3.32-50.5) p<0.05, respectively).…”

“…Despite the lack of common approaches to the early diagnosis and treatment of septic complications, some authors believe the mechanism of development is closely connected with the violation of cell membrane permeability and the subsequent translocation of intestinal flora through the intestinal membrane [3,4]. This is also favored by the age characteristics of the newborn with immaturity of the immune and barrier systems.…”