The Influence of Environmental Temperature on the Concentration of Pentobarbital and Barbital in the Liver and Brain

Sotaniemi, Eero A.

doi:10.1111/j.1600-0773.1967.tb03066.x

Acta Pharmacologica et Toxicologica

1967

DOI: 10.1111/j.1600-0773.1967.tb03066.x

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The Influence of Environmental Temperature on the Concentration of Pentobarbital and Barbital in the Liver and Brain

Eero A. Sotaniemi

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1971

1983

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Cited by 8 publications

References 70 publications

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Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse

Iven

Feldbusch

1983

Naunyn-Schmiedeberg's Arch. Pharmacol.

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The antiepileptic barbexaclone is the salt of the base propylhexedrine (indirect sympathomimetic) and phenylethylbituric acid. After i.v. and oral administration of 66 mg/kg barbexaclone to mice the time course of propylhexedrine and phenobarbital concentrations was studied in plasma, brain, lung, liver, kidney, spleen, heart, and skeletal muscle. Furthermore, the kinetics of phenobarbital were studied after treatment with an equimolar dose of phenobarbital-Na (40 mg/kg). In contrast to the i.v. bolus of phenobarbital-Na, barbexaclone was non-lethal only when infused over a period of 3 min. After the i.v. administration of either salt, phenobarbital plasma levels declined monoexponentially with a half-life of 7.5 h; the volume of distribution was 0.78 l/kg. After oral application absorption of phenobarbital was complete with both salts, though it was delayed after barbexaclone. The latter was the result of a delayed gastro-intestinal passage. Brain uptake of phenobarbital was a slow process, equilibrium with plasma concentrations being reached only 30 min after injection. Propylhexedrine reduced phenobarbital concentrations in brain as evident from steady state tissue-plasma ratios. This was observed after i.v. as well as after oral application. After i.v. application of barbexaclone the following pharmacokinetic parameters for propylhexedrine were determined: t0.5 alpha 0.31 h, t0.5 beta 2.5 h, Vd beta 19.3 l/kg; bioavailability (AUC oral/AUC i.v.) 0.37. Propylhexedrine penetrated the blood-brain barrier rapidly. High but unequal tissue accumulation was observed: lung = kidney greater than liver = brain greater than spleen greater than heart greater than skeletal muscle.

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Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse

Iven

Feldbusch

1983

Naunyn-Schmiedeberg's Arch. Pharmacol.

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Half-life of tolbutamide in patients with chronic respiratory failure

Arvela

Huhti

et al. 1971

Eur J Clin Pharmacol

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Effect of paraoxon on the hypnotic action of chloral hydrate

Koepke

Coon

Triolo

1974

Toxicology and Applied Pharmacology

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The Influence of Environmental Temperature on the Concentration of Pentobarbital and Barbital in the Liver and Brain

Cited by 8 publications

References 70 publications

Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse

Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse

Half-life of tolbutamide in patients with chronic respiratory failure

Effect of paraoxon on the hypnotic action of chloral hydrate

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