“…This finding, however, is in contrast to those of Ambre and his colleagues (Ambre, Graeff, Bures, Haupt & Deason, 1977) who observed that although antipyrine clearances were significantly higher in patients with bronchogenic carcinoma compared to normal controls, clearances in patients with chronic lung disease alone were no different. On the other hand, data suggesting that oxidative metabolism of tolbutamide and ethanol might be enhanced in patients with chronic respiratory disease Sotaniemi, Arvela, Huhti & Koivisto, 1971;Sotaniemi, Isoaho, Huhti, Huikko & Koivisto, 1972) support our own.…”