The Influence of Disintegrant Level and Capsule Size on Dissolution of Hard Gelatin Capsules Stored in High Humidity Conditions

Dahl, Terrence C.; Sue, I. T.; Yum, Alicia

doi:10.3109/03639049109040835

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…It was reported that, when the superdisintegrant was incorporated into the tablet, dissolution within 15 min was slower in the acidic medium than that in the neutral medium regardless of whether crosspovidone or crosscaramellose was used (Gordon et al, 1993). Also it was pointed out that in a capsule formula (PAR + dibasic calcium phosphate + magnesium stearate) the dissolution was faster in 0.1 N HCl than in deionized water due to the dibasic calcium phosphate excipients (Dahl et al, 1991). Furthermore, Chen et al (1997) reported that interaction between ingredients in tablets with PAR may lead to different dissolution rates, especially in the acidic medium (Chen et al, 1997).…”

Section: Disintegration and Dissolution Profilesmentioning

confidence: 99%

Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression

Govedarica

Injac²,

Dreu³

et al. 2009

Afr. J. Pharm. Pharmacol.

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Paracetamol (PAR) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of "Paracetamol for direct compression" are present on the market. Current research demonstrated the best tablet properties with coated paracetamol (mass of tablets, diameter, height and mechanical strength, friability RSD<2%). Furthermore, coated paracetamol in combination with both investigated superdisintegrants such as Vivasol ® and Polyplasdone ® XL-10 shows faster disintegration time and dissolution rate in comparison to paracetamol for direct compression. Eventually, the major advantages of the formulation with coated paracetamol for industrial production are decrease of friability and superiority in terms of flowability, compressibility, quick disintegration and dissolution. Regarding the results, coating of PAR particles is beneficial for the manufacturing of tablets with immediate release.

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Section: Disintegration and Dissolution Profilesmentioning

confidence: 99%

Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression

Govedarica

Injac²,

Dreu³

et al. 2009

Afr. J. Pharm. Pharmacol.

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“…The most commonly used pharmaceutical solid dosage forms today include granules, pellets, tablets and capsules. 1 Enteric coated dosage forms Enteric coated dosage forms are designed to resist the acidic environment of the stomach and to disintegrate in the higher pH environment of the intestinal fluid. Polymers for enteric coating can be applied to solid dosage forms (granules, pellets or tablets) from aqueous latex or pseudo latex dispersions, aqueous solutions of alkali salts or organic solvent solutions.…”

Section: Introductionmentioning

confidence: 99%

Design of Multi Unit Particulate System Containing Antiretro Viral Drugs

Sangita¹,

Verma²

2012

Journal of Pharmaceutical Research

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MUPS (Multi Unit Particulate System) of Didanosine were formulated using drug layering technique and were further compressed into tablets by using various excipients and polymers such as Micro crystalline cellulose in optimized amount to reduce the rupture of the enteric coating layer of MUPS. The Multi Unit Particulate System was prepared by drug layering onto the non pareil seeds followed by enteric coating. The prepared MUPS were found intact in simulated gastric fluid and released at intestinal pH. The controlled release of acid labile Didanosine from MUPS was influenced by the proportion of diluents added in tablet formulation to provide cushioning effect to MUPS. The release data evaluated by dissolution technique showed no release of drug at gastric pH and 100% release at intestinal pH.

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Capsule Product Design

2022

Integrated Pharmaceutics

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The Influence of Disintegrant Level and Capsule Size on Dissolution of Hard Gelatin Capsules Stored in High Humidity Conditions

Cited by 5 publications

References 13 publications

Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression

Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression

Design of Multi Unit Particulate System Containing Antiretro Viral Drugs

Capsule Product Design

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