Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression

Abstract

Paracetamol (PAR) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of "Paracetamol for direct compression" are present on the market. Current research demonstrated the best tablet properties with coated paracetamol (mass of tablets, diameter, height and mechanical strength, friability RSD<2%). Furthermore, coated paracetamol in combination with both investigated superdisintegrants such as Vivasol ® and Polyplasdone ® XL-10 shows faster disintegration time and dissolution rate in comparison to paracetamol for direct compression. Eventually, the major advantages of the formulation with coated paracetamol for industrial production are decrease of friability and superiority in terms of flowability, compressibility, quick disintegration and dissolution. Regarding the results, coating of PAR particles is beneficial for the manufacturing of tablets with immediate release.

Optimized chronomodulated dual release bilayer tablets of fexofenadine and montelukast: quality by design, development, and in vitro evaluation

“…Carr's index also indicates the flowability of the powder blend: 5-15%, excellent; 12-16%, good; 18-21%, fair; 23-35%, poor; 33-38%, very poor; and > 40%, extremely poor [18].…”

Evaluation of Physical Properties of Selected Excipients for Direct Compressible Tablet

“…Problem in flow property mainly gives rise to wet variation and tablet problems may be happened during manufacturing (Wu, et al, 2007). To know about flow property, it is important to determine the angle of repose as well as tapped and untapped density of different excipients (Govedarica et al, 2011). Usually bulk density is of great importance when one considers the size of a high-dose tablet product or the homogeneity of a low-dose formulation in which there are big differences in drug and excipients densities.…”

Investigation on the flow properties and compresibilities of different direct tableting agents by using pyridoxine hydrochloride as a model drug

“…Tablets are one of the most preferred dosage forms in pharmaceutical area due to easy manufacturing, dose accuracy, good patient compliance and relatively low cost (1)(2)(3)(4)(5)(6). There are several tablet manufacturing methods but the most appropriate technology for industrial production is direct compression.…”

“…The simplicity and reduced production cost are the primary advantages of this method. Direct compression is preferred in terms of better stability of active ingredient, relatively faster dissolution and reduces the documentation and validation requirements, and ensures the compliance to the requirements of current good manufacturing practices due to the lesser contamination risk (2,3,5,6). However, lots of pharmaceutical materials have poor compressibility properties.…”