The influence of directed hydrogen bonds on the self-assembly of amphiphilic polymers in water

Overcoming the Necessity of a Lateral Aggregation in the Formation of Supramolecular Polymer Bottlebrushes in Water

“…[ 12–27 ] Considering the latter, we have previously shown that the number of H‐bonds per central motif, and thus the interaction strength, is decisive to obtain SPBs. [ 28–30 ] However, next to the strength of the supramolecular interaction and the main axial assembly, a lateral assembly appears to be crucial for the formation of cylindrical structures, which is similarly observed for other of the above‐mentioned motifs.…”

“…Compounds 1a–c were further studied via sedimentation velocity experiments in the AUC to resolve apparent distributions of the sedimentation coefficients, s (Figure 1B). [ 28,29,33 ] For all three compounds, roughly monomodal distributions of s were observed with signal (weight) average sedimentation coefficients of s = 1.0 S ( 1a ), s = 2.4 S ( 1b ), and s = 3.3 S ( 1c ). The very small s ‐value for 1a is in accordance with the SAXS and cryoTEM results indicate the presence of unimers next to small aggregates.…”

“…For the preparation of our C 3 ‐symmetric benzenetrisureapeptide‐PEO conjugates (BTUPs), we combined the previously reported syntheses of C 3 ‐symmetric BTU and benzenetrispeptide (BTP) conjugates (Schemes S1 and S2, Supporting Information). [ 28–31 ] Different amino acids (alanine, leucine, and phenylalanine) were chosen to study the impact of the hydrophobicity of the respective amino acid and their ability to form additional π–π interactions in case of phenylalanine on the self‐assembled structures in water. The low solubility of the resulting compounds simplified the purification by precipitation, but the overall yields remained low due to the formation of gels during the reactions.…”

From Physical Chemistry to Chemical Physics

“…A range of spectroscopic and scattering techniques has unambiguously established that similar helical assemblies are present in liquid crystals, [11][12][13] in single crystals, 14,15 in dilute solutions [16][17][18][19] and in gels. [20][21][22] Introduction of functional groups at the periphery of BTA assemblies is required to favour their formation in water, [23][24][25][26][27][28][29] their hybridization with oligonucleotides, [30][31][32] or their implementation as catalysts, [33][34][35][36][37][38][39][40][41][42] circularly-polarized light emitters 43 or luminescent gels. 44 Moreover, mixing different types of BTA monomers has recently emerged as a remarkable method to control the chirality and structure of helical co-assemblies [45][46][47][48] and construct elaborate functional supramolecular materials.…”

Trendbericht: Makromolekulare Chemie

“…Wie der Vergleich mit Esterderivaten zeigt, haben die H-Brücken nur geringen Einfluss, und die Zusammensetzung dominiert hier die Morphologiebildung. 36) Wie Polysaccharidderivate mit Wasser wechselwirken, untersuchten Delbianco und Mitarbeiter. Sie ermittelten Struktur-Eigenschaftsbeziehungen durch spezifische Modifikation auf molekularem Level, um die 3-D-Struktur der Makromoleküle zu beeinflussen.…”